{"id":"https://openalex.org/W2920873246","doi":"https://doi.org/10.1117/12.2515022","title":"Coupled active shape models for automated segmentation and landmark localization in high-resolution CT of the foot and ankle","display_name":"Coupled active shape models for automated segmentation and landmark localization in high-resolution CT of the foot and ankle","publication_year":2019,"publication_date":"2019-03-15","ids":{"openalex":"https://openalex.org/W2920873246","doi":"https://doi.org/10.1117/12.2515022","mag":"2920873246","pmid":"https://pubmed.ncbi.nlm.nih.gov/31337927"},"language":"en","primary_location":{"id":"doi:10.1117/12.2515022","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2515022","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6647836","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090441302","display_name":"Michael Brehler","orcid":"https://orcid.org/0000-0002-4663-6587"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Brehler","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","Johns Hopkins Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011931390","display_name":"Asef Islam","orcid":"https://orcid.org/0000-0001-9825-9050"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asef Islam","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","Johns Hopkins Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112235803","display_name":"Levon Vogelsang","orcid":null},"institutions":[{"id":"https://openalex.org/I175669267","display_name":"Carestream (United States)","ror":"https://ror.org/048m16q57","country_code":"US","type":"company","lineage":["https://openalex.org/I175669267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levon O. Vogelsang","raw_affiliation_strings":["Carestream Health, Rochester, NY USA","Carestream Health, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carestream Health, Rochester, NY USA","institution_ids":[]},{"raw_affiliation_string":"Carestream Health, Inc. (United States)","institution_ids":["https://openalex.org/I175669267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031003824","display_name":"Dong Yang","orcid":"https://orcid.org/0000-0002-5031-4337"},"institutions":[{"id":"https://openalex.org/I175669267","display_name":"Carestream (United States)","ror":"https://ror.org/048m16q57","country_code":"US","type":"company","lineage":["https://openalex.org/I175669267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Yang","raw_affiliation_strings":["Carestream Health, Rochester, NY USA","Carestream Health, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carestream Health, Rochester, NY USA","institution_ids":[]},{"raw_affiliation_string":"Carestream Health, Inc. (United States)","institution_ids":["https://openalex.org/I175669267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083264349","display_name":"William J. Sehnert","orcid":"https://orcid.org/0009-0009-7615-7577"},"institutions":[{"id":"https://openalex.org/I175669267","display_name":"Carestream (United States)","ror":"https://ror.org/048m16q57","country_code":"US","type":"company","lineage":["https://openalex.org/I175669267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Sehnert","raw_affiliation_strings":["Carestream Health, Rochester, NY USA","Carestream Health, Inc. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carestream Health, Rochester, NY USA","institution_ids":[]},{"raw_affiliation_string":"Carestream Health, Inc. (United States)","institution_ids":["https://openalex.org/I175669267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112392421","display_name":"Delaram Shakoor","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Delaram Shakoor","raw_affiliation_strings":["Department of Radiology, Johns Hopkins University, Baltimore, MD USA","Johns Hopkins Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University, Baltimore, MD USA","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071300687","display_name":"Shadpour Demehri","orcid":"https://orcid.org/0000-0001-5991-5924"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shadpour Demehri","raw_affiliation_strings":["Department of Radiology, Johns Hopkins University, Baltimore, MD USA","Johns Hopkins Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University, Baltimore, MD USA","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068070550","display_name":"Jeffrey H. Siewerdsen","orcid":"https://orcid.org/0000-0001-6644-1317"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey H. Siewerdsen","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","Department of Radiology, Johns Hopkins University, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Radiology, Johns Hopkins University, Baltimore, MD USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079368329","display_name":"Wojciech Zbijewski","orcid":"https://orcid.org/0000-0001-7593-5394"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wojciech Zbijewski","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","Johns Hopkins Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5090441302"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":9.955,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.97320786,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10137","issue":null,"first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10992","display_name":"Forensic Anthropology and Bioarchaeology Studies","score":0.3260999917984009,"subfield":{"id":"https://openalex.org/subfields/1204","display_name":"Archeology"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10992","display_name":"Forensic Anthropology and Bioarchaeology Studies","score":0.3260999917984009,"subfield":{"id":"https://openalex.org/subfields/1204","display_name":"Archeology"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14510","display_name":"Medical Imaging and Analysis","score":0.12950000166893005,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.07559999823570251,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/landmark","display_name":"Landmark","score":0.8424184322357178},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8009869456291199},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.7391882538795471},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7196788191795349},{"id":"https://openalex.org/keywords/foot","display_name":"Foot (prosody)","score":0.6000311374664307},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5801018476486206},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.551132321357727},{"id":"https://openalex.org/keywords/ankle","display_name":"Ankle","score":0.48303040862083435},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.4536170959472656},{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.43325960636138916},{"id":"https://openalex.org/keywords/resolution","display_name":"Resolution (logic)","score":0.4259057641029358},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.13509628176689148},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.12701424956321716},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07043510675430298}],"concepts":[{"id":"https://openalex.org/C2780297707","wikidata":"https://www.wikidata.org/wiki/Q4895393","display_name":"Landmark","level":2,"score":0.8424184322357178},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8009869456291199},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.7391882538795471},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7196788191795349},{"id":"https://openalex.org/C115076146","wikidata":"https://www.wikidata.org/wiki/Q1651051","display_name":"Foot (prosody)","level":2,"score":0.6000311374664307},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5801018476486206},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.551132321357727},{"id":"https://openalex.org/C2778640784","wikidata":"https://www.wikidata.org/wiki/Q168002","display_name":"Ankle","level":2,"score":0.48303040862083435},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.4536170959472656},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.43325960636138916},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4259057641029358},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.13509628176689148},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12701424956321716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07043510675430298},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2515022","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2515022","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},{"id":"pmid:31337927","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31337927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6647836","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6647836","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6647836","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6647836","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/11","display_name":"Sustainable cities and communities"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2009398710","https://openalex.org/W2038952578","https://openalex.org/W2106542522","https://openalex.org/W2124451810","https://openalex.org/W2134236847","https://openalex.org/W2279554476","https://openalex.org/W2310713243","https://openalex.org/W2339820241","https://openalex.org/W2596246398","https://openalex.org/W2757652467","https://openalex.org/W2892134524","https://openalex.org/W4206710654","https://openalex.org/W6734926090"],"related_works":["https://openalex.org/W2056853153","https://openalex.org/W2057559274","https://openalex.org/W2005087563","https://openalex.org/W2378111931","https://openalex.org/W4243161226","https://openalex.org/W2950647290","https://openalex.org/W2156119078","https://openalex.org/W158240165","https://openalex.org/W2391085069","https://openalex.org/W4389691184"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1,98],"develop":[2],"an":[3],"Active":[4],"Shape":[5],"Model":[6],"(ASM)":[7],"framework":[8,331],"for":[9,43,75,159,186,273],"automated":[10,349],"bone":[11,178,237],"segmentation":[12,110,225,239],"and":[13,111,117,137,174,182,189,218,309,358],"anatomical":[14,156,350],"landmark":[15,112,202,212,278],"localization":[16,113,203,279],"in":[17,29,47,119,169,258,277,315,339,352],"weight-bearing":[18,106],"Cone-Beam":[19],"CT":[20],"(CBCT).":[21],"To":[22],"achieve":[23],"a":[24,40,85,127,298],"robust":[25],"shape":[26,57,131,179,194,217,224,267,324,335,366],"model":[27,300,325,336],"fit":[28,66,91],"narrow":[30,361],"joint":[31,362],"spaces":[32,363],"of":[33,59,95,104,115,133,145,162,192,220,226,236,266,296,323,334,341,355],"the":[34,68,78,105,146,170,190,215,221,227,287,304,321,356],"foot":[35,62,107,163,357],"(0.5":[36],"-":[37],"1":[38],"mm),":[39],"new":[41],"approach":[42,347],"incorporating":[44],"proximity":[45,76],"constraints":[46],"ASM":[48,88,116,181,246],"(coupled":[49],"ASM,":[50],"cASM)":[51],"is":[52,301],"proposed.":[53],"METHODS:":[54],"In":[55],"cASM,":[56],"models":[58,132,151],"multiple":[60],"adjacent":[61],"bones":[63],"are":[64],"jointly":[65],"to":[67,81,92,108,247,270,282,317],"CBCT":[69,102,172],"volume.":[70],"This":[71],"coupling":[72],"enables":[73,348],"checking":[74],"between":[77,211,312],"evolving":[79,313],"shapes":[80,314],"avoid":[82],"situations":[83],"where":[84,360],"conventional":[86,245,365],"single-bone":[87],"might":[89],"erroneously":[90],"articular":[93],"surfaces":[94],"neighbouring":[96],"bones.":[97],"used":[99,125,158],"21":[100],"extremity":[101],"scans":[103],"compare":[109],"accuracy":[114,333],"cASM":[118,183,253,290,307,330],"leave-one-out":[120],"validation.":[121],"Each":[122],"scan":[123],"was":[124,196,204,280],"as":[126],"test":[128,228],"image":[129],"once;":[130],"calcaneus,":[134],"talus,":[135],"navicular,":[136],"cuboid":[138],"were":[139,152,167,184],"built":[140],"from":[141,241],"manual":[142],"surface":[143,238],"segmentations":[144],"remaining":[147],"20":[148],"scans.":[149],"The":[150,165,294,328,346],"augmented":[153],"with":[154,244,250,261,289,292],"seven":[155],"landmarks":[157,166],"common":[160],"measurements":[161],"alignment.":[164],"identified":[168],"original":[171],"volumes":[173],"mapped":[175],"onto":[176],"mean":[177,216],"surfaces.":[180],"run":[185],"100":[187],"iterations,":[188],"number":[191],"principal":[193],"components":[195],"increased":[197],"every":[198],"10":[199],"iterations.":[200],"Automated":[201],"achieved":[205,254],"by":[206,303],"applying":[207],"known":[208],"point":[209],"correspondences":[210],"vertices":[213,219],"on":[214,286,320],"final":[222],"active":[223],"image.":[229],"RESULTS:":[230],"Root":[231],"Mean":[232],"Squared":[233],"(RMS)":[234],"error":[235,260,276],"improved":[240],"3.6":[242],"mm":[243,249],"2.7":[248],"cASM.":[251],"Furthermore,":[252],"convergence":[255],"(no":[256],"change":[257],"RMS":[259],"iteration)":[262],"after":[263],"~40":[264],"iterations":[265,272],"fitting,":[268],"compared":[269],"~60":[271],"ASM.":[274,293],"Distance":[275],"25%":[281],"55%":[283],"lower":[284],"(depending":[285,319],"landmark)":[288],"than":[291],"importance":[295],"using":[297],"coupled":[299],"underscored":[302],"finding":[305],"that":[306],"detected":[308],"corrected":[310],"collisions":[311],"50%":[316],"80%":[318],"bone)":[322],"fits.":[326],"CONCLUSION:":[327],"proposed":[329],"improves":[332],"fits,":[337],"especially":[338],"complexes":[340],"tightly":[342],"interlocking,":[343],"articulated":[344],"joints.":[345],"analysis":[351],"volumetric":[353],"imaging":[354],"ankle,":[359],"challenge":[364],"models.":[367]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}