{"id":"https://openalex.org/W2921386096","doi":"https://doi.org/10.1117/12.2513561","title":"Breast MRI radiomics for the pre-treatment prediction of response to neoadjuvant chemotherapy in node-positive breast cancer patients","display_name":"Breast MRI radiomics for the pre-treatment prediction of response to neoadjuvant chemotherapy in node-positive breast cancer patients","publication_year":2019,"publication_date":"2019-03-13","ids":{"openalex":"https://openalex.org/W2921386096","doi":"https://doi.org/10.1117/12.2513561","mag":"2921386096"},"language":"en","primary_location":{"id":"doi:10.1117/12.2513561","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2513561","pdf_url":null,"source":{"id":"https://openalex.org/S4363606689","display_name":"SPIE Medical Imaging: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Computer-Aided Diagnosis","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024321936","display_name":"Karen Drukker","orcid":"https://orcid.org/0000-0001-6544-3476","observed_orcids":["https://orcid.org/0000-0001-6544-3476"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Drukker","raw_affiliation_strings":["The Univ. of Chicago (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Chicago (United States)","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Iman El-Bawab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iman El-Bawab","raw_affiliation_strings":["The Univ. of Chicago (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Chicago (United States)","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012021404","display_name":"Alexandra V. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Edwards","raw_affiliation_strings":["The Univ. of Chicago (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Chicago (United States)","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Doyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Doyle","raw_affiliation_strings":["The Univ. of Chicago (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Chicago (United States)","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020468113","display_name":"John Papaioannou","orcid":"https://orcid.org/0000-0002-3852-3208","observed_orcids":["https://orcid.org/0000-0002-3852-3208"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Papaioannou","raw_affiliation_strings":["The Univ. of Chicago (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Chicago (United States)","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061839907","display_name":"Kirti Kulkarni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirti Kulkarni","raw_affiliation_strings":["The Univ. of Chicago (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Chicago (United States)","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049042648","display_name":"Maryellen Lissak Giger","orcid":"https://orcid.org/0000-0001-5482-9728","observed_orcids":["https://orcid.org/0000-0001-5482-9728"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryellen L. Giger","raw_affiliation_strings":["The Univ. of Chicago (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Chicago (United States)","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":5.7641,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.96219136,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":null,"first_page":"95","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-mri","display_name":"breast MRI","score":0.8040000200271606},{"id":"https://openalex.org/keywords/radiomics","display_name":"radiomics","score":0.996999979019165},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy-response","display_name":"neoadjuvant chemotherapy response","score":0.8529999852180481},{"id":"https://openalex.org/keywords/node-positive-breast-cancer","display_name":"node-positive breast cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lymph-node-status-prediction","display_name":"lymph node status prediction","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sentinel-lymph-node","display_name":"sentinel lymph node","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dce-mri","display_name":"DCE-MRI","score":0.8659999966621399},{"id":"https://openalex.org/keywords/radiomics-feature-selection","display_name":"radiomic feature selection","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7904641628265381},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7707196474075317},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.60328608751297},{"id":"https://openalex.org/C2780212769","wikidata":"https://www.wikidata.org/wiki/Q776290","display_name":"Sentinel lymph node","level":4,"score":0.5288851261138916},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5163132548332214},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5029093623161316},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4947780966758728},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4864771068096161},{"id":"https://openalex.org/C2777111374","wikidata":"https://www.wikidata.org/wiki/Q4959770","display_name":"Breast MRI","level":5,"score":0.44578588008880615},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.4405263662338257},{"id":"https://openalex.org/C2777649267","wikidata":"https://www.wikidata.org/wiki/Q340695","display_name":"Axillary lymph nodes","level":4,"score":0.4369364380836487},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.41262906789779663},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40005403757095337},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.331368625164032},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.269361287355423},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.20540091395378113},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.20230340957641602},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2513561","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2513561","pdf_url":null,"source":{"id":"https://openalex.org/S4363606689","display_name":"SPIE Medical Imaging: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Computer-Aided Diagnosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8500000238418579,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W66614814","https://openalex.org/W212537071","https://openalex.org/W1992489994","https://openalex.org/W1996440595","https://openalex.org/W2007754818","https://openalex.org/W2038833688","https://openalex.org/W2059165786","https://openalex.org/W2061568180","https://openalex.org/W2182711918"],"related_works":["https://openalex.org/W3092280193","https://openalex.org/W2359235302","https://openalex.org/W2515320062","https://openalex.org/W3210297477","https://openalex.org/W1955989960","https://openalex.org/W2094618537","https://openalex.org/W2410672908","https://openalex.org/W2132499182","https://openalex.org/W4365145537","https://openalex.org/W1972699103"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,36,43,148,168,183],"this":[3],"study":[4,51],"was":[5,163],"to":[6,14,19,165,212],"evaluate":[7],"breast":[8,29,91],"MRI":[9],"radiomics":[10],"in":[11,23,142,171,194],"predicting,":[12],"prior":[13],"any":[15],"treatment,":[16],"the":[17,112,117,123,143,149,158,172,200,226,230,233,240],"response":[18,39,61,216],"neoadjuvant":[20],"chemotherapy":[21],"(NAC)":[22],"patients":[24,54,72],"with":[25,55,221],"invasive":[26],"lymph":[27,46,100,120,207],"node-positive":[28],"cancer":[30],"for":[31,111,116],"2":[32,173],"tasks:":[33],"1)":[34],"prediction":[35,42],"pathologic":[37,60,196,214],"complete":[38,59,197,215],"and":[40,66,76,96,115,130,204,217,247],"2)":[41],"post-":[44],"NAC":[45],"node":[47,208],"(LN)":[48],"status.":[49],"Our":[50],"included":[52],"158":[53],"19":[56],"showing":[57,68],"post-NAC":[58,74,79,218],"(pathologic":[62],"TNM":[63],"stage":[64],"T0,N0,MX)":[65],"139":[67],"incomplete":[69],"response,":[70],"42":[71],"were":[73,78,108,153,210],"LN-negative":[75],"116":[77],"LN-positive.":[80],"Only":[81],"pre-NAC":[82,188,206],"MRIs":[83,126],"underwent":[84],"computer":[85],"analysis,":[86],"initialized":[87],"by":[88,137,146,180],"an":[89],"expert":[90],"radiologist":[92],"indicating":[93],"index":[94],"cancers":[95,114],"metastatic":[97,118],"axillary":[98],"sentinel":[99,119],"nodes":[101],"on":[102],"DCE-MRI":[103,236],"images.":[104],"Forty-nine":[105],"radiomic":[106],"features":[107,135,170,177,209],"extracted,":[109],"both":[110],"primary":[113],"nodes.":[121],"Since":[122],"dataset":[124],"contained":[125],"acquired":[127],"at":[128,131,232],"1.5T":[129],"3.0T,":[132],"we":[133],"eliminated":[134],"affected":[136],"magnet":[138,181],"strength":[139],"as":[140,222],"demonstrated":[141],"Mann-Whitney":[144],"U-test":[145],"rejection":[147],"null-hypothesis":[150],"that":[151],"samples":[152],"selected":[154],"from":[155],"populations":[156],"having":[157],"same":[159],"distribution.":[160],"ROC":[161,241],"analysis":[162],"used":[164],"assess":[166],"performance":[167],"individual":[169],"classification":[174],"tasks.":[175],"Eighteen":[176],"appeared":[178],"unaffected":[179],"strength,":[182],"which":[184],"only":[185],"a":[186],"single":[187],"tumor":[189],"feature":[190,225],"outperformed":[191],"random":[192],"guessing":[193],"predicting":[195],"response.":[198],"On":[199],"other":[201],"hand,":[202],"13":[203],"10":[205],"able":[211],"predict":[213],"LN-status,":[219],"respectively,":[220],"most":[223],"promising":[224],"standard":[227],"deviation":[228],"within":[229],"LN":[231],"first":[234],"postcontrast":[235],"time-point":[237],"(areas":[238],"under":[239],"curve:":[242],"0.79":[243],"(standard":[244],"error":[245],"0.06)":[246],"0.70":[248],"(0.05),":[249],"respectively).":[250]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2025-10-10T00:00:00"}