{"id":"https://openalex.org/W2922213230","doi":"https://doi.org/10.1117/12.2513113","title":"Quantitative assessment of dMRI-based dentate-rubro-thalamic tractography in squirrel monkey","display_name":"Quantitative assessment of dMRI-based dentate-rubro-thalamic tractography in squirrel monkey","publication_year":2019,"publication_date":"2019-03-15","ids":{"openalex":"https://openalex.org/W2922213230","doi":"https://doi.org/10.1117/12.2513113","mag":"2922213230"},"language":"en","primary_location":{"id":"doi:10.1117/12.2513113","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2513113","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031488038","display_name":"Yurui Gao","orcid":"https://orcid.org/0000-0002-4339-5351"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yurui Gao","raw_affiliation_strings":["Vanderbilt Univ. (United States)","Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056838937","display_name":"Kurt G. Schilling","orcid":"https://orcid.org/0000-0003-3686-7645"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt G. Schilling","raw_affiliation_strings":["Vanderbilt Univ. (United States)","Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060726223","display_name":"Iwona Stepniewska","orcid":"https://orcid.org/0000-0001-6680-1845"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iwona Stepniewska","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108677749","display_name":"Guozhen Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guozhen Luo","raw_affiliation_strings":["Vanderbilt Univ. (United States)","Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075735203","display_name":"Bennett A. Landman","orcid":"https://orcid.org/0000-0001-5733-2127"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett Landman","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102846064","display_name":"Hong Yu","orcid":"https://orcid.org/0000-0003-0107-9489"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Yu","raw_affiliation_strings":["Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064135529","display_name":"Daniel O. Claassen","orcid":"https://orcid.org/0000-0002-9853-4902"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Claassen","raw_affiliation_strings":["Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014896512","display_name":"Beno\u00eet M. Dawant","orcid":"https://orcid.org/0000-0002-3804-8400"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benoit Dawant","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044056811","display_name":"Adam W. Anderson","orcid":"https://orcid.org/0000-0002-3788-6138"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam W. Anderson","raw_affiliation_strings":["Vanderbilt Univ. (United States)","Vanderbilt Univ. Medical Ctr. (United States)"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. Medical Ctr. (United States)","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5031488038"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03090649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/squirrel-monkey","display_name":"Squirrel monkey","score":0.5730338096618652},{"id":"https://openalex.org/keywords/tractography","display_name":"Tractography","score":0.5624386668205261},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4499635398387909},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4062488079071045},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.29469090700149536},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.2024351954460144},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11846831440925598},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.05757918953895569}],"concepts":[{"id":"https://openalex.org/C2776030879","wikidata":"https://www.wikidata.org/wiki/Q309200","display_name":"Squirrel monkey","level":2,"score":0.5730338096618652},{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.5624386668205261},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4499635398387909},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4062488079071045},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29469090700149536},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.2024351954460144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11846831440925598},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.05757918953895569},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2513113","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2513113","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W212537071","https://openalex.org/W599620915","https://openalex.org/W1972543511","https://openalex.org/W1984453610","https://openalex.org/W2000133863","https://openalex.org/W2025162361","https://openalex.org/W2035801035","https://openalex.org/W2039861760","https://openalex.org/W2045572694","https://openalex.org/W2062865989","https://openalex.org/W2079329115","https://openalex.org/W2079795772","https://openalex.org/W2124227727","https://openalex.org/W2127309075","https://openalex.org/W2137915146","https://openalex.org/W2149476088","https://openalex.org/W2156588995","https://openalex.org/W2589582210","https://openalex.org/W2590688054","https://openalex.org/W2765999949","https://openalex.org/W2887072805","https://openalex.org/W2891717570","https://openalex.org/W3214876686","https://openalex.org/W4230825363","https://openalex.org/W4238797488","https://openalex.org/W4239378726","https://openalex.org/W4250556866","https://openalex.org/W4253243873","https://openalex.org/W6733597608","https://openalex.org/W6733751554"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W1995447559","https://openalex.org/W2021941342","https://openalex.org/W2178716887","https://openalex.org/W2011793707","https://openalex.org/W2111353772","https://openalex.org/W2741858986","https://openalex.org/W2044802448","https://openalex.org/W2159208769"],"abstract_inverted_index":{"Background:":[0],"The":[1,177],"dentate-rubro-thalamic-tract":[2],"(DRTT)":[3],"has":[4,48],"recently":[5],"been":[6,50],"suggested":[7],"as":[8,55,183,192,229],"a":[9,56,119,221,230],"new":[10],"target":[11],"in":[12,36,86,98],"treatment":[13],"of":[14,18,42,63,75,121,127,153,173,179,186,214,224,234],"tremors":[15],"for":[16,111,232],"patients":[17],"essential":[19],"tremor":[20],"and":[21,106,132,135,190],"Parkinson\u2019s":[22],"disease.":[23],"Diffusion":[24],"MRI":[25],"(dMRI)":[26],"tractography":[27,44,79,115],"was":[28,96,116,140,148],"reported":[29],"to":[30,32,59,71,242],"able":[31],"reconstruct":[33],"DRTT":[34,78,138,145,225],"non-invasively":[35],"human":[37],"brain.":[38,89,156],"However,":[39],"the":[40,61,73,76,87,136,154,158,171,184,193,212],"performance":[41],"dMRI":[43,163,180,205],"with":[45,82,101,118,143,166,208],"different":[46],"setups":[47],"not":[49],"rigorously":[51],"evaluated,":[52],"which":[53,147,227],"serves":[54,228],"necessary":[57],"step":[58,130],"optimize":[60],"protocol":[62,235],"reconstruction.":[64],"Purpose:":[65],"In":[66],"this":[67],"study,":[68],"we":[69],"aim":[70],"assess":[72],"efficacy":[74],"dMRI-based":[77],"by":[80,162],"comparing":[81],"histological":[83,144,167,174,209,215],"\u201cground":[84],"truth\u201d":[85],"same":[88,155],"Method:":[90],"A":[91],"fixed":[92],"squirrel":[93],"monkey":[94],"brain":[95],"scanned":[97],"9.4T":[99],"magnet":[100],"four":[102],"shells":[103],"(b=3000/6000/9000/12000s/mm<sup>2</sup>":[104],")":[105],"100":[107],"diffusion":[108],"gradient":[109,128,187],"directions":[110,188],"each":[112],"shell.":[113],"Probabilistic":[114],"implemented":[117],"set":[120],"variables":[122],"(i.e.,":[123],"b":[124,198],"value,":[125],"number":[126,185],"directions,":[129],"length":[131],"binarization":[133,194],"threshold),":[134],"dMRI-derived":[137],"volume":[139],"quantitatively":[141],"compared":[142,165],"volume,":[146],"obtained":[149],"from":[150,204,237],"Myelin":[151],"stain":[152],"Moreover,":[157],"primary":[159,201],"orientations":[160,169,202],"estimated":[161,203],"were":[164],"fiber":[168],"along":[170,211],"skeleton":[172,213],"DRTT.":[175,216],"Result:":[176],"sensitivity":[178],"measure":[181],"increases":[182,189],"decreases":[191],"threshold":[195],"increases.":[196],"As":[197],"value":[199],"increases,":[200],"agree":[206],"more":[207],"ones":[210],"Conclusion:":[217],"Our":[218],"work":[219],"provides":[220],"valuable":[222],"assessment":[223],"tractography,":[226],"guideline":[231],"optimization":[233],"starting":[236],"image":[238],"acquisition,":[239],"orientation":[240],"estimation":[241],"tractography.":[243]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
