{"id":"https://openalex.org/W2921566855","doi":"https://doi.org/10.1117/12.2512983","title":"Classification of autism spectrum disorder from resting-state fMRI with mutual connectivity analysis","display_name":"Classification of autism spectrum disorder from resting-state fMRI with mutual connectivity analysis","publication_year":2019,"publication_date":"2019-03-15","ids":{"openalex":"https://openalex.org/W2921566855","doi":"https://doi.org/10.1117/12.2512983","mag":"2921566855"},"language":"en","primary_location":{"id":"doi:10.1117/12.2512983","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2512983","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068409005","display_name":"Adora M. DSouza","orcid":"https://orcid.org/0000-0001-5656-0021"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adora M. DSouza","raw_affiliation_strings":["Univ. of Rochester (United States)"],"affiliations":[{"raw_affiliation_string":"Univ. of Rochester (United States)","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022256468","display_name":"Anas Z. Abidin","orcid":"https://orcid.org/0000-0003-0032-0664"},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anas Z. Abidin","raw_affiliation_strings":["Univ. of Rochester  (United States)"],"affiliations":[{"raw_affiliation_string":"Univ. of Rochester  (United States)","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036396088","display_name":"Axel Wism\u00fcller","orcid":null},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Axel Wism\u00fcller","raw_affiliation_strings":["Ludwig Maximilian Univ. (Germany)","Univ. of Rochester  (United States)"],"affiliations":[{"raw_affiliation_string":"Ludwig Maximilian Univ. (Germany)","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Univ. of Rochester  (United States)","institution_ids":["https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068409005"],"corresponding_institution_ids":["https://openalex.org/I5388228"],"apc_list":null,"apc_paid":null,"fwci":0.7297,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68154066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"116","issue":null,"first_page":"47","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.815784215927124},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"Autism spectrum disorder","score":0.7778515815734863},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.7024981379508972},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.48799318075180054},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46634310483932495},{"id":"https://openalex.org/keywords/autism","display_name":"Autism","score":0.36815521121025085},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3561933636665344},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.35271111130714417},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32768845558166504},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.10173913836479187}],"concepts":[{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.815784215927124},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.7778515815734863},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.7024981379508972},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48799318075180054},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46634310483932495},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.36815521121025085},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3561933636665344},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35271111130714417},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32768845558166504},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10173913836479187}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2512983","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2512983","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6499999761581421,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W133892329","https://openalex.org/W1507544250","https://openalex.org/W1518405882","https://openalex.org/W1706864547","https://openalex.org/W1930624869","https://openalex.org/W1964107394","https://openalex.org/W1965481579","https://openalex.org/W1972228177","https://openalex.org/W1988790447","https://openalex.org/W1997269994","https://openalex.org/W1998945666","https://openalex.org/W2006591500","https://openalex.org/W2011988161","https://openalex.org/W2017345738","https://openalex.org/W2034476862","https://openalex.org/W2044713450","https://openalex.org/W2058046532","https://openalex.org/W2060721178","https://openalex.org/W2061690543","https://openalex.org/W2061957656","https://openalex.org/W2083278075","https://openalex.org/W2092481496","https://openalex.org/W2102292745","https://openalex.org/W2103961356","https://openalex.org/W2120759354","https://openalex.org/W2123923307","https://openalex.org/W2130107054","https://openalex.org/W2141317097","https://openalex.org/W2148585001","https://openalex.org/W2149018240","https://openalex.org/W2150901369","https://openalex.org/W2155904360","https://openalex.org/W2169472037","https://openalex.org/W2172180476","https://openalex.org/W2332715186","https://openalex.org/W2464525596","https://openalex.org/W2494820207","https://openalex.org/W2522924024","https://openalex.org/W2593687779","https://openalex.org/W2803807974","https://openalex.org/W3099014884","https://openalex.org/W4237028743","https://openalex.org/W4247665917","https://openalex.org/W4252143507","https://openalex.org/W4294398017","https://openalex.org/W4301429599","https://openalex.org/W6653524013","https://openalex.org/W6674352590","https://openalex.org/W6678568454","https://openalex.org/W6684817826","https://openalex.org/W6685179704","https://openalex.org/W6734509241","https://openalex.org/W6785241104"],"related_works":["https://openalex.org/W1520477417","https://openalex.org/W3150454329","https://openalex.org/W4250679599","https://openalex.org/W4236064658","https://openalex.org/W4232465970","https://openalex.org/W4244025530","https://openalex.org/W4233336045","https://openalex.org/W2283746446","https://openalex.org/W3145575137","https://openalex.org/W4252587867"],"abstract_inverted_index":{"In":[0],"this":[1,30],"study,":[2],"we":[3,32,78,136],"investigate":[4,33,138],"if":[5],"differences":[6],"in":[7,54],"interaction":[8,49],"between":[9,50,167,174,185,191,198],"different":[10,156],"brain":[11],"regions":[12],"for":[13,68,75,154,229,236],"subjects":[14,69],"with":[15,40,89,126,141,179],"autism":[16],"spectrum":[17],"disorder":[18],"(ASD)":[19],"and":[20,70,99,151,171,195,226],"healthy":[21],"controls":[22],"can":[23],"be":[24,216],"captured":[25],"using":[26,162,183],"resting-state":[27],"fMRI.":[28],"To":[29],"end,":[31],"the":[34,83,86,90,204,223,230],"use":[35],"of":[36,48,52,56,65,85,121,206,232],"mutual":[37],"connectivity":[38,66,109,123],"analysis":[39,117,182],"Local":[41],"Models":[42],"(MCA-LM),":[43],"which":[44],"estimates":[45],"nonlinear":[46,213],"measures":[47,60,110,120],"pairs":[51],"time-series":[53,187,224],"terms":[55],"cross-predictability.":[57],"These":[58],"pairwise":[59],"provide":[61],"a":[62,130,212],"high-dimensional":[63],"representation":[64],"profiles":[67],"are":[71,102,124],"used":[72],"as":[73,114,129],"features":[74,207],"classification.":[76],"Subsequently,":[77],"perform":[79],"feature":[80],"selection,":[81],"reducing":[82],"dimension":[84],"input":[87],"space":[88],"Kendall\u2019s":[91],"\u03c4":[92],"coefficient":[93],"method.":[94],"The":[95,143],"Random":[96],"Forests":[97],"(RF)":[98],"AdaBoost":[100],"classifiers":[101,161],"used.":[103],"Performing":[104],"machine":[105],"learning":[106],"on":[107],"functional":[108,122],"is":[111],"commonly":[112],"known":[113],"multi-voxel":[115],"pattern":[116],"(MVPA).":[118],"Traditionally,":[119],"obtained":[125],"cross-correlation.":[127,142],"Hence,":[128],"metric":[131],"to":[132],"evaluate":[133],"MCA-LM":[134,163],"against,":[135],"also":[137],"classification":[139],"performance":[140],"high":[144],"area":[145],"under":[146],"receiver":[147],"operating":[148],"curve":[149],"(AUC)":[150],"accuracy":[152,173,197],"values":[153],"100":[155],"train/test":[157],"separations":[158],"across":[159,202],"both":[160],"(mean":[164,188],"AUC":[165,189],"ranges":[166,190],"0.78":[168],"-":[169,176,193,200],"0.85":[170],"mean":[172,196],"0.7":[175],"0.81)":[177],"compared":[178],"standard":[180],"MVPA":[181],"cross-correlation":[184],"fMRI":[186],"0.54":[192],"0.6":[194],"0.50":[199],"0.57),":[201],"all":[203],"number":[205],"selected":[208],"demonstrates":[209],"that":[210],"such":[211],"measure":[214],"may":[215],"better":[217],"suited":[218],"at":[219],"extracting":[220],"information":[221],"from":[222],"data":[225],"has":[227],"potential":[228],"development":[231],"novel":[233],"neuro-imaging":[234],"biomarkers":[235],"ASD.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}