{"id":"https://openalex.org/W2920882662","doi":"https://doi.org/10.1117/12.2512965","title":"Lung cancer detection using co-learning from chest CT images and clinical demographics","display_name":"Lung cancer detection using co-learning from chest CT images and clinical demographics","publication_year":2019,"publication_date":"2019-03-14","ids":{"openalex":"https://openalex.org/W2920882662","doi":"https://doi.org/10.1117/12.2512965","mag":"2920882662","pmid":"https://pubmed.ncbi.nlm.nih.gov/31602088"},"language":"en","primary_location":{"id":"doi:10.1117/12.2512965","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2512965","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Image Processing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100404541","display_name":"Jiachen Wang","orcid":"https://orcid.org/0000-0003-3888-1387"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiachen Wang","raw_affiliation_strings":["Computer Science, Vanderbilt University, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Computer Science, Vanderbilt University, Nashville, TN, USA 37235","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078051038","display_name":"Riqiang Gao","orcid":"https://orcid.org/0000-0002-8729-1941"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riqiang Gao","raw_affiliation_strings":["Computer Science, Vanderbilt University, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Computer Science, Vanderbilt University, Nashville, TN, USA 37235","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067191302","display_name":"Yuankai Huo","orcid":"https://orcid.org/0000-0002-2096-8065"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuankai Huo","raw_affiliation_strings":["Electrical Engineering, Vanderbilt University, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Electrical Engineering, Vanderbilt University, Nashville, TN, USA 37235","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048972725","display_name":"Shunxing Bao","orcid":"https://orcid.org/0000-0001-6376-4292"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shunxing Bao","raw_affiliation_strings":["Computer Science, Vanderbilt University, Nashville, TN, USA 37235"],"affiliations":[{"raw_affiliation_string":"Computer Science, Vanderbilt University, Nashville, TN, USA 37235","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087883340","display_name":"Yunxi Xiong","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunxi Xiong","raw_affiliation_strings":["Computer Science, Vanderbilt University, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Computer Science, Vanderbilt University, Nashville, TN, USA 37235","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108136531","display_name":"Sanja Antic","orcid":"https://orcid.org/0000-0002-6948-8003"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanja L. Antic","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN, USA 37235","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049126384","display_name":"Travis Osterman","orcid":"https://orcid.org/0000-0002-2841-8121"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis J. Osterman","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA 37235","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061560898","display_name":"Pierre P. Massion","orcid":"https://orcid.org/0000-0003-0647-0559"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre P. Massion","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN, USA 37235","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075735203","display_name":"Bennett A. Landman","orcid":"https://orcid.org/0000-0001-5733-2127"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett A. Landman","raw_affiliation_strings":["Computer Science, Vanderbilt University, Nashville, TN, USA 37235","Electrical Engineering, Vanderbilt University, Nashville, TN, USA 37235","Vanderbilt Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Computer Science, Vanderbilt University, Nashville, TN, USA 37235","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Electrical Engineering, Vanderbilt University, Nashville, TN, USA 37235","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100404541"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":3.1122,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.92223354,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10949","issue":null,"first_page":"122","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11775","display_name":"COVID-19 diagnosis using AI","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.7116280198097229},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6479894518852234},{"id":"https://openalex.org/keywords/demographics","display_name":"Demographics","score":0.6435988545417786},{"id":"https://openalex.org/keywords/lung-cancer-screening","display_name":"Lung cancer screening","score":0.6082596182823181},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5933644771575928},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5863826870918274},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5691495537757874},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.5059005618095398},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4791561961174011},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"Computed tomography","score":0.4309467673301697},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.42482346296310425},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4025120735168457},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35374122858047485},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3402462303638458},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.17418533563613892}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.7116280198097229},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6479894518852234},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.6435988545417786},{"id":"https://openalex.org/C2777405583","wikidata":"https://www.wikidata.org/wiki/Q6704277","display_name":"Lung cancer screening","level":3,"score":0.6082596182823181},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5933644771575928},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5863826870918274},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5691495537757874},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5059005618095398},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4791561961174011},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.4309467673301697},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.42482346296310425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4025120735168457},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35374122858047485},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3402462303638458},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17418533563613892},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2512965","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2512965","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Image Processing","raw_type":"proceedings-article"},{"id":"pmid:31602088","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31602088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:5745458","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6786775","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W130099911","https://openalex.org/W2235523093","https://openalex.org/W2769848455","https://openalex.org/W2797594039","https://openalex.org/W2802349450","https://openalex.org/W2805279773","https://openalex.org/W3102476541","https://openalex.org/W6633658626","https://openalex.org/W6746260709","https://openalex.org/W6750996985","https://openalex.org/W6751473295","https://openalex.org/W6910681941"],"related_works":["https://openalex.org/W3121380072","https://openalex.org/W2058403539","https://openalex.org/W2942793592","https://openalex.org/W2602311653","https://openalex.org/W2333615638","https://openalex.org/W2964230772","https://openalex.org/W2768231286","https://openalex.org/W2409976527","https://openalex.org/W4386259002","https://openalex.org/W1546989560"],"abstract_inverted_index":{"Early":[0],"detection":[1,92],"of":[2,17,84,93,119,169,187],"lung":[3,24,94,108],"cancer":[4,25,109],"is":[5,104],"essential":[6],"in":[7],"reducing":[8],"mortality.":[9],"Recent":[10],"studies":[11],"have":[12],"demonstrated":[13],"the":[14,77,111,120,126,152,162,190,210],"clinical":[15,33,64,143,156,179],"utility":[16],"low-dose":[18],"computed":[19],"tomography":[20],"(CT)":[21],"to":[22,46,106,139,145],"detect":[23],"among":[26],"individuals":[27],"selected":[28],"based":[29],"on":[30,90,189],"very":[31],"limited":[32],"information.":[34],"However,":[35],"this":[36,71],"strategy":[37],"yields":[38],"high":[39],"false":[40],"positive":[41],"rates,":[42],"which":[43,88],"can":[44],"lead":[45],"unnecessary":[47],"and":[48,66,81,131,180,203],"potentially":[49],"harmful":[50],"procedures.":[51],"To":[52,123],"address":[53],"such":[54],"challenges,":[55],"we":[56,73,133,183],"established":[57],"a":[58,135,140],"pipeline":[59,177],"that":[60,151,208,212],"co-learns":[61],"from":[62,76,110,155],"detailed":[63],"demographics":[65,157],"3D":[67,97],"CT":[68,113],"images.":[69],"Toward":[70],"end,":[72],"leveraged":[74],"data":[75],"Consortium":[78],"for":[79,201],"Molecular":[80],"Cellular":[82],"Characterization":[83],"Screen-Detected":[85],"Lesions":[86],"(MCL),":[87],"focuses":[89],"early":[91],"cancer.":[95],"A":[96],"attention-based":[98],"deep":[99],"convolutional":[100],"neural":[101],"net":[102],"(DCNN)":[103],"proposed":[105,176,194],"identify":[107],"chest":[112],"scan":[114],"without":[115],"prior":[116],"anatomical":[117,199],"location":[118],"suspicious":[121],"nodule.":[122],"improve":[124],"upon":[125],"non-invasive":[127],"discrimination":[128],"between":[129],"benign":[130],"malignant,":[132],"applied":[134],"random":[136],"forest":[137],"classifier":[138],"dataset":[141],"integrating":[142,178],"information":[144,200],"imaging":[146,181],"data.":[147],"The":[148,193],"results":[149],"show":[150],"AUC":[153,186],"obtained":[154],"alone":[158,165],"was":[159],"0.635":[160],"while":[161],"attention":[163,206],"network":[164,195],"reached":[166,184],"an":[167,185],"accuracy":[168],"0.687.":[170],"In":[171],"contrast":[172],"when":[173],"applying":[174],"our":[175],"variables,":[182],"0.787":[188],"testing":[191],"dataset.":[192],"both":[196],"efficiently":[197],"captures":[198],"classification":[202],"also":[204],"generates":[205],"maps":[207],"explain":[209],"features":[211],"drive":[213],"performance.":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}