{"id":"https://openalex.org/W2921696836","doi":"https://doi.org/10.1117/12.2512849","title":"Development and evaluation of pulmonary imaging multi-parametric response maps for deep phenotyping of chronic obstructive pulmonary disease","display_name":"Development and evaluation of pulmonary imaging multi-parametric response maps for deep phenotyping of chronic obstructive pulmonary disease","publication_year":2019,"publication_date":"2019-03-15","ids":{"openalex":"https://openalex.org/W2921696836","doi":"https://doi.org/10.1117/12.2512849","mag":"2921696836"},"language":"en","primary_location":{"id":"doi:10.1117/12.2512849","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2512849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000211754","display_name":"Jonathan L. MacNeil","orcid":"https://orcid.org/0000-0002-6526-9778"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan L. MacNeil","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061798247","display_name":"Dante P. I. Capaldi","orcid":"https://orcid.org/0000-0002-4590-7461"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dante P. I. Capaldi","raw_affiliation_strings":["Standford Univ. (United States)","Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Standford Univ. (United States)","institution_ids":[]},{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039762217","display_name":"Rachel L. Eddy","orcid":"https://orcid.org/0000-0002-2541-1645"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rachel L. Eddy","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075668975","display_name":"Andrew Westcott","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew R. Westcott","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043197283","display_name":"Alexander M. Matheson","orcid":"https://orcid.org/0000-0002-6022-9507"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexander M. Matheson","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076555655","display_name":"Andrea L. Barker","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrea L. Barker","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030981495","display_name":"Cathy Ong Ly","orcid":"https://orcid.org/0000-0002-4328-1581"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cathy Ong Ly","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020583398","display_name":"David G. McCormack","orcid":"https://orcid.org/0000-0003-1129-1141"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David G. McCormack","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072668158","display_name":"Grace P\u00e1rraga","orcid":"https://orcid.org/0000-0002-5619-4145"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Grace Parraga","raw_affiliation_strings":["Univ. of Western Ontario (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0409645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7626","issue":null,"first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.6897237300872803},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.5787167549133301},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.5764961242675781},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5010242462158203},{"id":"https://openalex.org/keywords/pulmonary-disease","display_name":"Pulmonary disease","score":0.5008623600006104},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.4566158652305603},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42411336302757263},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37627458572387695},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3216075301170349},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.309457004070282},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3071008324623108},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.09366250038146973},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09230583906173706}],"concepts":[{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.6897237300872803},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.5787167549133301},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5764961242675781},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5010242462158203},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.5008623600006104},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4566158652305603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42411336302757263},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37627458572387695},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3216075301170349},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.309457004070282},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3071008324623108},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.09366250038146973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09230583906173706}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2512849","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2512849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W31831759","https://openalex.org/W200617456","https://openalex.org/W212537071","https://openalex.org/W214577476","https://openalex.org/W1983592655","https://openalex.org/W2026752633","https://openalex.org/W2035121718","https://openalex.org/W2037810426","https://openalex.org/W2040022821","https://openalex.org/W2059587208","https://openalex.org/W2060515724","https://openalex.org/W2071866426","https://openalex.org/W2080505000","https://openalex.org/W2082907106","https://openalex.org/W2087387762","https://openalex.org/W2096579040","https://openalex.org/W2100148404","https://openalex.org/W2121296185","https://openalex.org/W2122590281","https://openalex.org/W2125078269","https://openalex.org/W2140775860","https://openalex.org/W2232125376","https://openalex.org/W2324542191","https://openalex.org/W2534071065","https://openalex.org/W2884234612","https://openalex.org/W4206679801","https://openalex.org/W4233974599","https://openalex.org/W6656961040","https://openalex.org/W6669114609","https://openalex.org/W6753674463","https://openalex.org/W7074005974"],"related_works":["https://openalex.org/W3027020613","https://openalex.org/W2016533837","https://openalex.org/W3167885074","https://openalex.org/W2892386716","https://openalex.org/W4306164210","https://openalex.org/W2038239089","https://openalex.org/W2471562626","https://openalex.org/W2461863667","https://openalex.org/W2295804706","https://openalex.org/W3168515805"],"abstract_inverted_index":{"Objective:":[0],"Our":[1],"aim":[2],"was":[3,139],"to":[4,34,173,257],"develop":[5],"and":[6,19,24,55,70,75,78,100,149,198,210,219,228,254],"evaluate":[7],"multi-parametric":[8,63],"response":[9,64],"maps":[10,31,65,117,170,179],"derived":[11],"from":[12],"pulmonary":[13,40],"x-ray":[14],"computed":[15],"tomography":[16],"(CT),":[17],"1H":[18,77],"hyperpolarized":[20],"3He":[21,69,79,125],"static":[22],"ventilation":[23,56],"diffusion-weighted":[25],"magnetic":[26],"resonance":[27],"imaging":[28,62],"(MRI).":[29],"These":[30],"were":[32,73,82,94,103,118,130,152,171,180,246],"generated":[33,181],"phenotype":[35,258],"patients":[36],"with":[37,158,187,196,208,217,226,235,241],"chronic":[38],"obstructive":[39],"disease":[41,189],"(COPD)":[42],"based":[43],"on":[44],"the":[45,89,164],"presence":[46],"of":[47],"airways":[48],"disease,":[49],"air":[50],"trapping,":[51],"emphysema,":[52],"alveolar":[53],"distension,":[54],"defects.":[57],"Methods:":[58],"To":[59],"generate":[60,174],"thoracic":[61,169],"(mPRM),":[66],"multispectral":[67],"1H,":[68],"CT":[71,101,151,255],"images":[72,81,93,102,129],"segmented":[74,83,95,104,115],"co-registered.":[76],"MR":[80,92],"using":[84,96,105,120,132,141,154],"a":[85,97,159,249],"semi-automated":[86],"segmentation":[87],"algorithm,":[88],"diffusion":[90,127,201],"weighted":[91,128],"threshold-based":[98],"algorithm":[99],"Pulmonary":[106],"Workstation":[107],"2.0":[108],"(VIDA":[109],"Diagnostics,":[110],"Coralville,":[111],"IA).":[112],"The":[113,124,167],"volume-matched":[114],"1H/3He":[116],"registered":[119,131],"landmark":[121],"rigid":[122,135],"registration.":[123,136],"maps/the":[126],"an":[133,155],"intensity-based":[134],"CT-to-MRI":[137],"co-registration":[138],"achieved":[140],"modality-independent":[142],"neighborhood":[143],"descriptor":[144],"(MIND)":[145],"deformable":[146,160],"registration;":[147],"inspiratory":[148],"expiratory":[150],"co-registered":[153,168],"affine":[156],"registration":[157],"step":[161],"provided":[162],"by":[163],"NiftyReg":[165],"toolkit.":[166],"used":[172],"multiparametric":[175],"maps.":[176],"Results:":[177],"mPRM":[178,244],"for":[182,252],"six":[183],"different":[184],"voxel":[185],"classifications":[186],"increasing":[188],"abnormality/severity":[190],"as":[191],"follows:":[192],"1)":[193],"ventilated":[194,206,215,224],"voxels":[195,207,216,225,234,240],">-856HU/>-950HU":[197,218],"normal":[199,220],"apparent":[200],"coefficient":[202],"(ADC)":[203],"values,":[204,213,222,231],"2)":[205],"<-856HU/<-950HU":[209,227],"abnormal":[211,229],"ADC":[212,221,230],"3)":[214],"4)":[223],"5)":[232],"unventilated":[233,239],">-856HU/>-950HU,":[236],"and,":[237],"6)":[238],"<-856HU/<-950HU.":[242],"Conclusion:":[243],"measurements":[245,256],"automated":[247],"in":[248],"dedicated":[250],"pipeline":[251],"MRI":[253],"COPD":[259],"patients.":[260]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
