{"id":"https://openalex.org/W2793957891","doi":"https://doi.org/10.1117/12.2293941","title":"Sequential neural networks for biologically informed glioma segmentation","display_name":"Sequential neural networks for biologically informed glioma segmentation","publication_year":2018,"publication_date":"2018-03-02","ids":{"openalex":"https://openalex.org/W2793957891","doi":"https://doi.org/10.1117/12.2293941","mag":"2793957891"},"language":"en","primary_location":{"id":"doi:10.1117/12.2293941","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293941","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Image Processing","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003185083","display_name":"Andrew Beers","orcid":"https://orcid.org/0009-0005-9085-6412"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew Beers","raw_affiliation_strings":["Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039622318","display_name":"Ken Chang","orcid":"https://orcid.org/0000-0001-6956-5059"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Chang","raw_affiliation_strings":["Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013498181","display_name":"James M. Brown","orcid":"https://orcid.org/0000-0001-7636-4554"},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Brown","raw_affiliation_strings":["Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082835319","display_name":"Elizabeth R. Gerstner","orcid":"https://orcid.org/0000-0003-2382-3838"},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Gerstner","raw_affiliation_strings":["Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004268054","display_name":"Bruce R. Rosen","orcid":"https://orcid.org/0000-0002-8576-0839"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Rosen","raw_affiliation_strings":["Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039535916","display_name":"Jayashree Kalpathy\u2013Cramer","orcid":"https://orcid.org/0000-0001-8906-9618"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayashree Kalpathy-Cramer","raw_affiliation_strings":["Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I4210127055","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003185083"],"corresponding_institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210127055"],"apc_list":null,"apc_paid":null,"fwci":1.0172,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76087068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"108","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.8268629312515259},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7835276126861572},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6841743588447571},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.6535537242889404},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6325198411941528},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5578460097312927},{"id":"https://openalex.org/keywords/fluid-attenuated-inversion-recovery","display_name":"Fluid-attenuated inversion recovery","score":0.5304583311080933},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.43564337491989136},{"id":"https://openalex.org/keywords/market-segmentation","display_name":"Market segmentation","score":0.43195435404777527},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.42492926120758057},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4025547504425049},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.38236531615257263},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.11185657978057861},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07831820845603943},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0736268162727356},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.06367573142051697}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.8268629312515259},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7835276126861572},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6841743588447571},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.6535537242889404},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6325198411941528},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5578460097312927},{"id":"https://openalex.org/C101070640","wikidata":"https://www.wikidata.org/wiki/Q3737215","display_name":"Fluid-attenuated inversion recovery","level":3,"score":0.5304583311080933},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.43564337491989136},{"id":"https://openalex.org/C125308379","wikidata":"https://www.wikidata.org/wiki/Q363057","display_name":"Market segmentation","level":2,"score":0.43195435404777527},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.42492926120758057},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4025547504425049},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.38236531615257263},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.11185657978057861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07831820845603943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0736268162727356},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.06367573142051697},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2293941","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293941","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Image Processing","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W582134693","https://openalex.org/W1550975546","https://openalex.org/W1641498739","https://openalex.org/W1812256879","https://openalex.org/W1836465849","https://openalex.org/W1884191083","https://openalex.org/W1901129140","https://openalex.org/W1991791143","https://openalex.org/W1996190316","https://openalex.org/W2026616100","https://openalex.org/W2029119154","https://openalex.org/W2095109797","https://openalex.org/W2100242207","https://openalex.org/W2117340355","https://openalex.org/W2125647485","https://openalex.org/W2129366802","https://openalex.org/W2134431790","https://openalex.org/W2141349487","https://openalex.org/W2146719828","https://openalex.org/W2162643152","https://openalex.org/W2163854509","https://openalex.org/W2164675211","https://openalex.org/W2208071854","https://openalex.org/W2301358467","https://openalex.org/W2322783123","https://openalex.org/W2346352626","https://openalex.org/W2460918282","https://openalex.org/W2464708700","https://openalex.org/W2557738935","https://openalex.org/W2581082771","https://openalex.org/W2612201027","https://openalex.org/W2624092670","https://openalex.org/W2743501370","https://openalex.org/W2751538714","https://openalex.org/W2772723798","https://openalex.org/W2903382683","https://openalex.org/W2977883299","https://openalex.org/W4245392732","https://openalex.org/W6617145748","https://openalex.org/W6639824700","https://openalex.org/W6737762388","https://openalex.org/W6739395325","https://openalex.org/W6757107679"],"related_works":["https://openalex.org/W2397888002","https://openalex.org/W2356247871","https://openalex.org/W2373716292","https://openalex.org/W2381429000","https://openalex.org/W2364564193","https://openalex.org/W2393352769","https://openalex.org/W2131742827","https://openalex.org/W4389341328","https://openalex.org/W4309923383","https://openalex.org/W2408873457"],"abstract_inverted_index":{"In":[0],"the":[1,50,71,81,129],"last":[2],"five":[3],"years,":[4],"advances":[5],"in":[6,12,108],"processing":[7,14],"power":[8],"and":[9,31,94,119,138,152,163,169,172],"computational":[10],"efficiency":[11],"graphical":[13],"units":[15],"have":[16],"catalyzed":[17],"dozens":[18],"of":[19,28,35,42,73,84,92],"deep":[20,67,100],"neural":[21,51,68,101],"network":[22],"segmentation":[23,45,76,141],"algorithms":[24,37],"for":[25,65,115],"a":[26,62,104,109],"variety":[27],"target":[29],"tissues":[30],"malignancies.":[32],"However,":[33],"few":[34],"these":[36],"preconfigure":[38],"any":[39],"biological":[40],"context":[41],"their":[43],"chosen":[44],"tissues,":[46],"instead":[47],"relying":[48],"on":[49,159,177],"network\u2019s":[52],"optimizer":[53],"to":[54,70,112,149],"develop":[55],"such":[56,127],"associations":[57],"de":[58],"novo.":[59],"We":[60,97,155],"present":[61],"novel":[63],"method":[64],"applying":[66],"networks":[69,102],"problem":[72],"glioma":[74],"tissue":[75,88],"that":[77,128],"takes":[78],"into":[79,146],"account":[80],"structured":[82],"nature":[83],"gliomas":[85],"&ndash;":[86],"edematous":[87],"surrounding":[89],"mutually-exclusive":[90],"regions":[91],"enhancing":[93,120,151],"non-enhancing":[95,117,153],"tumor.":[96,154],"trained":[98,156,175],"separate":[99,147],"with":[103],"3D":[105],"U-Net":[106],"architecture":[107],"tree":[110],"structure":[111],"create":[113],"segmentations":[114],"edema,":[116],"tumor,":[118],"tumor":[121,131],"regions.":[122],"Specifically,":[123],"training":[124],"was":[125,135,142],"configured":[126],"whole":[130],"region":[132],"including":[133],"edema":[134],"predicted":[136],"first,":[137],"its":[139],"output":[140],"fed":[143],"as":[144],"input":[145],"models":[148],"predict":[150],"our":[157,174],"model":[158,176],"publicly":[160],"available":[161],"pre-":[162],"post-contrast":[164],"T1":[165],"images,":[166,168,171],"T2":[167],"FLAIR":[170],"validated":[173],"patient":[178],"data":[179],"from":[180],"an":[181],"ongoing":[182],"clinical":[183],"trial.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
