{"id":"https://openalex.org/W2790752770","doi":"https://doi.org/10.1117/12.2293850","title":"Optimization of an iodine-based nanoparticle contrast agent for molecular CT imaging","display_name":"Optimization of an iodine-based nanoparticle contrast agent for molecular CT imaging","publication_year":2018,"publication_date":"2018-03-12","ids":{"openalex":"https://openalex.org/W2790752770","doi":"https://doi.org/10.1117/12.2293850","mag":"2790752770"},"language":"en","primary_location":{"id":"doi:10.1117/12.2293850","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293850","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068231163","display_name":"K. Ghaghada","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ketankumar Ghaghada","raw_affiliation_strings":["Texas Children's Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Texas Children's Hospital (United States)","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063613898","display_name":"Chandreshkumar Patel","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandreshkumar Patel","raw_affiliation_strings":["Texas Children's Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Texas Children's Hospital (United States)","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082450718","display_name":"Ananth Annapragada","orcid":"https://orcid.org/0000-0002-3156-9617"},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ananth Annapragada","raw_affiliation_strings":["Texas Children's Hospital (United States)"],"affiliations":[{"raw_affiliation_string":"Texas Children's Hospital (United States)","institution_ids":["https://openalex.org/I4210147586"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068231163"],"corresponding_institution_ids":["https://openalex.org/I4210147586"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01787078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iodine","display_name":"Iodine","score":0.7351505756378174},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.6973510980606079},{"id":"https://openalex.org/keywords/moiety","display_name":"Moiety","score":0.5695865750312805},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"Molecular imaging","score":0.5018966197967529},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4948810935020447},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4230327010154724},{"id":"https://openalex.org/keywords/particle-size","display_name":"Particle size","score":0.4224422872066498},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.42145252227783203},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38457193970680237},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.10832950472831726}],"concepts":[{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.7351505756378174},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6973510980606079},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.5695865750312805},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.5018966197967529},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4948810935020447},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4230327010154724},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4224422872066498},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.42145252227783203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38457193970680237},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.10832950472831726},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2293850","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293850","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W657244191","https://openalex.org/W2016619029","https://openalex.org/W2036743656","https://openalex.org/W2044617758","https://openalex.org/W2065262077","https://openalex.org/W2076226743","https://openalex.org/W2105050495","https://openalex.org/W2134771619","https://openalex.org/W2135553830","https://openalex.org/W2268486799","https://openalex.org/W2592398622","https://openalex.org/W2736617187","https://openalex.org/W4236541489","https://openalex.org/W6734315552"],"related_works":["https://openalex.org/W2376082430","https://openalex.org/W2299503928","https://openalex.org/W1480924375","https://openalex.org/W2390476533","https://openalex.org/W4210408838","https://openalex.org/W2890264855","https://openalex.org/W1967409193","https://openalex.org/W2951828435","https://openalex.org/W2362471872","https://openalex.org/W2137761396"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,8,138,148],"CT":[3,16,23,76],"hardware":[4],"have":[5],"renewed":[6],"interest":[7],"the":[9,86,128,137,156,191,221,241],"development":[10,26],"of":[11,36,48,59,108,127,158,168,182,220,232,243],"contrast":[12,164,234],"agents":[13],"for":[14,22,67,74],"molecular":[15,75],"imaging.":[17],"Nanoparticle":[18],"platforms":[19],"are":[20],"attractive":[21],"imaging":[24,37,77,87,147,215],"agent":[25],"due":[27],"to":[28,31,51,85,94,154],"their":[29],"ability":[30],"carry":[32],"a":[33,229],"high":[34],"payload":[35],"moieties,":[38],"thereby":[39],"facilitating":[40],"signal":[41,80],"amplification":[42],"at":[43],"target":[44],"site,":[45],"and":[46,116,136,162,185,236],"ease":[47],"surface":[49],"modification":[50],"enable":[52],"selective":[53],"<i>in":[54,124,217],"vivo</i>":[55,218],"targeting":[56],"against":[57],"cells/molecules":[58],"interest.":[60],"In":[61],"this":[62],"work,":[63],"we":[64],"performed":[65,93,153],"investigations":[66],"optimizing":[68],"an":[69,97],"iodine-based":[70],"liposomal":[71,111],"nanoparticle":[72,99,161,197,224,244],"platform":[73],"applications.":[78],"Since":[79],"intensity":[81],"is":[82],"directly":[83],"proportional":[84],"moiety":[88,115,184],"concentration,":[89],"optimization":[90,175],"studies":[91,176,227],"were":[92,120,152],"rationally":[95],"design":[96],"iodinated":[98],"construct":[100],"with":[101],"maximal":[102],"iodine":[103,114,118,159,163,183,187,192,204,210,233],"carrying":[104],"capacity.":[105],"The":[106,123],"effect":[107,231],"particle":[109,179],"size,":[110,180],"bilayer":[112],"composition,":[113],"starting":[117,186],"concentration":[119,188],"systematically":[121],"investigated.":[122],"vitro</i>":[125,174],"stability":[126,140,219],"optimal":[129],"formulation":[130],"was":[131,141,199],"evaluated":[132],"using":[133],"plasma":[134],"assay":[135],"vivo":[139],"tested":[142],"by":[143],"performing":[144],"longitudinal":[145],"micro-CT":[146],"live":[149],"animals.":[150],"Simulations":[151],"study":[155],"effects":[157],"per":[160,170,194,212],"sensitivity":[165,235],"on":[166,240],"detectability":[167],"nanoparticles":[169],"image":[171,237],"voxel.":[172],"<i>In":[173],"demonstrated":[177,202,216,228],"that":[178,201],"type":[181],"strongly":[189],"influenced":[190],"loading":[193,205],"nanoparticle.":[195],"A":[196],"composition":[198],"identified":[200],"highest":[203],"capacity":[206],"(&sim;":[207],"8":[208],"million":[209],"atoms":[211],"particle).":[213],"Micro-CT":[214],"high-iodine":[222],"containing":[223],"construct.":[225],"Simulation":[226],"non-linear":[230],"voxel":[238],"size":[239],"limit":[242],"detectability.":[245]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
