{"id":"https://openalex.org/W2789942159","doi":"https://doi.org/10.1117/12.2293846","title":"Micromechanics based modelling of in-vivo respiratory motion of the diaphragm muscle with the incorporation of optimized z-disks mechanics","display_name":"Micromechanics based modelling of in-vivo respiratory motion of the diaphragm muscle with the incorporation of optimized z-disks mechanics","publication_year":2018,"publication_date":"2018-03-13","ids":{"openalex":"https://openalex.org/W2789942159","doi":"https://doi.org/10.1117/12.2293846","mag":"2789942159"},"language":"en","primary_location":{"id":"doi:10.1117/12.2293846","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293846","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032679624","display_name":"Brett Nelson Coelho","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brett N. Coelho","raw_affiliation_strings":["Western Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053150293","display_name":"Abbas Samani","orcid":"https://orcid.org/0000-0002-9352-0587"},"institutions":[{"id":"https://openalex.org/I4210105758","display_name":"Robarts Clinical Trials","ror":"https://ror.org/01e36dv41","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4210105758","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abbas Samani","raw_affiliation_strings":["Robarts Research Institute (Canada)","Western Univ. (Canada)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robarts Research Institute (Canada)","institution_ids":["https://openalex.org/I4210105758"]},{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03310852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9415","issue":null,"first_page":"92","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9854999780654907,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diaphragm","display_name":"Diaphragm (acoustics)","score":0.7532967329025269},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5753424167633057},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.5164089798927307},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.4806458055973053},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.47776687145233154},{"id":"https://openalex.org/keywords/respiratory-system","display_name":"Respiratory system","score":0.4622798264026642},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4546040892601013},{"id":"https://openalex.org/keywords/respiratory-physiology","display_name":"Respiratory physiology","score":0.4302733540534973},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4279499650001526},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2811572849750519},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2637099325656891},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.24516001343727112},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.1891557276248932},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17537018656730652},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1745907962322235}],"concepts":[{"id":"https://openalex.org/C164292776","wikidata":"https://www.wikidata.org/wiki/Q5271779","display_name":"Diaphragm (acoustics)","level":3,"score":0.7532967329025269},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5753424167633057},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5164089798927307},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4806458055973053},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47776687145233154},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4622798264026642},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4546040892601013},{"id":"https://openalex.org/C163498912","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiratory physiology","level":3,"score":0.4302733540534973},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4279499650001526},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2811572849750519},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2637099325656891},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.24516001343727112},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1891557276248932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17537018656730652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1745907962322235},{"id":"https://openalex.org/C157138929","wikidata":"https://www.wikidata.org/wiki/Q570","display_name":"Loudspeaker","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2293846","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293846","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8799999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W78684768","https://openalex.org/W1992095417","https://openalex.org/W1993829198","https://openalex.org/W1994458323","https://openalex.org/W2045665459","https://openalex.org/W2054030154","https://openalex.org/W2073870596","https://openalex.org/W2086659830","https://openalex.org/W2094073039","https://openalex.org/W2101535145","https://openalex.org/W2127480863","https://openalex.org/W2130069261","https://openalex.org/W2164782003","https://openalex.org/W2166606679","https://openalex.org/W2410056570","https://openalex.org/W2480589279","https://openalex.org/W2504206636","https://openalex.org/W4235755055","https://openalex.org/W6603174545","https://openalex.org/W6671989426","https://openalex.org/W6679377681","https://openalex.org/W6980242863"],"related_works":["https://openalex.org/W2355955825","https://openalex.org/W2159756520","https://openalex.org/W2467154790","https://openalex.org/W2002025313","https://openalex.org/W2257501913","https://openalex.org/W2149818922","https://openalex.org/W2150255757","https://openalex.org/W1139815076","https://openalex.org/W2027319905","https://openalex.org/W2331300245"],"abstract_inverted_index":{"Lung":[0,47],"cancer":[1,9,27,48],"is":[2,51,107,117,150,213],"by":[3],"far":[4],"the":[5,18,38,71,90,127,156,175,186,195,210,223,245],"leading":[6],"cause":[7],"of":[8,25,159,188,194,222,258],"death":[10],"among":[11],"both":[12,199],"men":[13],"and":[14,55,114,177,201,206,247],"women;":[15],"according":[16],"to":[17,31,99,132,171,215,227],"American":[19],"Cancer":[20],"Society,":[21],"approximately":[22],"1":[23],"out":[24],"4":[26],"deaths":[28],"are":[29],"due":[30],"lung":[32,64,102,167],"cancer.":[33],"The":[34,153],"primary":[35],"treatment":[36],"for":[37,60,73,84,119,124],"condition":[39],"generally":[40,52],"involves":[41,185],"External":[42],"Beam":[43],"Radiation":[44],"Therapy":[45],"(EBRT).":[46],"tumour":[49,65,81,91,105,120,125,137],"motion":[50,66,74],"clinically":[53],"significant":[54,63],"presents":[56],"a":[57,115,189,217,236,241],"major":[58,157],"challenge":[59],"clinicians.":[61],"With":[62],"(&gt;;5mm)":[67],"during":[68,180],"respiration":[69],"comes":[70],"requirement":[72],"compensation":[75,141],"techniques<sup>1</sup>":[76],".":[77,139,182],"Ideally,":[78],"continuous":[79,85],"real-time":[80],"tracking":[82,106],"allows":[83],"radiation":[86,94],"delivery":[87],"such":[88],"that":[89],"receives":[92],"sufficient":[93],"dose":[95,98],"while":[96],"minimizing":[97],"surrounding":[100,178],"healthy":[101],"tissue.":[103],"Direct":[104],"often":[108,143],"not":[109],"possible":[110],"in":[111,174,225,230],"non-contrast":[112],"images":[113],"surrogate":[116],"required":[118],"motion.":[121,232],"Among":[122],"surrogates":[123],"tracking,":[126],"diaphragm":[128,154,196,224,250],"muscle":[129,197,211],"has":[130],"shown":[131],"provide":[133],"good":[134,242],"correlation":[135],"with":[136,198,252],"motion<sup>2</sup>":[138],"Motion":[140],"techniques":[142],"require":[144],"extensive":[145],"4D":[146],"CT":[147],"scans":[148],"which":[149],"inherently":[151],"dangerous.":[152],"muscle,":[155],"driver":[158],"respiratory":[160],"motion,":[161],"can":[162],"also":[163],"be":[164],"incorporated":[165],"into":[166],"biomechanical":[168,192],"models":[169],"used":[170,214],"predict":[172,228],"deformations":[173],"lungs":[176],"organs":[179],"respiration<sup>3</sup>":[181],"This":[183],"research":[184],"development":[187],"patient":[190,237],"specific":[191,238],"model":[193],"passive":[200],"active":[202],"responses.":[203],"Detailed":[204],"anatomical,":[205],"geometric":[207],"information,":[208],"including":[209],"micromechanics,":[212],"generate":[216],"Finite":[218],"Element":[219],"Model":[220],"(FEM)":[221],"order":[226],"its":[229],"vivo":[231],"Results":[233],"from":[234],"modelling":[235],"case":[239],"revealed":[240],"match":[243],"between":[244],"simulated":[246],"actual":[248],"contracted":[249],"surface":[251],"an":[253],"average":[254],"mean":[255],"squared":[256],"difference":[257],"2.83":[259],"mm.":[260]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}