{"id":"https://openalex.org/W2794045538","doi":"https://doi.org/10.1117/12.2293207","title":"Association of high proliferation marker Ki-67 expression with DCEMR imaging features of breast: a large scale evaluation","display_name":"Association of high proliferation marker Ki-67 expression with DCEMR imaging features of breast: a large scale evaluation","publication_year":2018,"publication_date":"2018-02-27","ids":{"openalex":"https://openalex.org/W2794045538","doi":"https://doi.org/10.1117/12.2293207","mag":"2794045538"},"language":"en","primary_location":{"id":"doi:10.1117/12.2293207","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293207","pdf_url":null,"source":{"id":"https://openalex.org/S4306519508","display_name":"Medical Imaging 2018: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Computer-Aided Diagnosis","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054599006","display_name":"Ashirbani Saha","orcid":"https://orcid.org/0000-0002-7650-1720"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210145671","display_name":"Advanced Imaging Research (United States)","ror":"https://ror.org/047c3xe48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashirbani Saha","raw_affiliation_strings":["Carl E. Ravin Advanced Imaging Labs. (United States)","Duke Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Carl E. Ravin Advanced Imaging Labs. (United States)","institution_ids":["https://openalex.org/I4210145671"]},{"raw_affiliation_string":"Duke Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023835104","display_name":"Michael R. Harowicz","orcid":"https://orcid.org/0000-0002-8002-5210"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210145671","display_name":"Advanced Imaging Research (United States)","ror":"https://ror.org/047c3xe48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Harowicz","raw_affiliation_strings":["Carl E. Ravin Advanced Imaging Labs. (United States)","Duke Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Carl E. Ravin Advanced Imaging Labs. (United States)","institution_ids":["https://openalex.org/I4210145671"]},{"raw_affiliation_string":"Duke Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014628303","display_name":"Lars J. Grimm","orcid":"https://orcid.org/0000-0002-3865-3352"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lars J. Grimm","raw_affiliation_strings":["Duke Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023414339","display_name":"Connie E. Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connie E. Kim","raw_affiliation_strings":["Duke Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016647185","display_name":"Ruth Walsh","orcid":"https://orcid.org/0000-0002-2164-2761"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Walsh","raw_affiliation_strings":["Duke Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109911799","display_name":"Sujata V. Ghate","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujata V. Ghate","raw_affiliation_strings":["Duke Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Duke Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001300575","display_name":"Maciej A. Mazurowski","orcid":"https://orcid.org/0000-0003-4202-8602"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210145671","display_name":"Advanced Imaging Research (United States)","ror":"https://ror.org/047c3xe48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maciej A. Mazurowski","raw_affiliation_strings":["Carl E. Ravin Advanced Imaging Labs. (United States)","Duke Univ. Medical Physics Program (United States)","Duke Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Carl E. Ravin Advanced Imaging Labs. (United States)","institution_ids":["https://openalex.org/I4210145671"]},{"raw_affiliation_string":"Duke Univ. Medical Physics Program (United States)","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5054599006"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210145671"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02296884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":null,"first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-imaging","display_name":"Breast imaging","score":0.48688116669654846},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4843791425228119},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4673479199409485},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.42695170640945435},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32676994800567627},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22488635778427124},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17083033919334412},{"id":"https://openalex.org/keywords/mammography","display_name":"Mammography","score":0.1532016396522522},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.13659262657165527},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.08129432797431946},{"id":"https://openalex.org/keywords/cartography","display_name":"Cartography","score":0.07891669869422913}],"concepts":[{"id":"https://openalex.org/C2777432617","wikidata":"https://www.wikidata.org/wiki/Q22905905","display_name":"Breast imaging","level":5,"score":0.48688116669654846},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4843791425228119},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4673479199409485},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.42695170640945435},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32676994800567627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22488635778427124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17083033919334412},{"id":"https://openalex.org/C2780472235","wikidata":"https://www.wikidata.org/wiki/Q324634","display_name":"Mammography","level":4,"score":0.1532016396522522},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.13659262657165527},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.08129432797431946},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.07891669869422913},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2293207","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2293207","pdf_url":null,"source":{"id":"https://openalex.org/S4306519508","display_name":"Medical Imaging 2018: Computer-Aided Diagnosis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Computer-Aided Diagnosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1926596361","https://openalex.org/W1965814195","https://openalex.org/W1977295091","https://openalex.org/W2001968322","https://openalex.org/W2040872996","https://openalex.org/W2117305280","https://openalex.org/W2123932528","https://openalex.org/W2127057139","https://openalex.org/W2165178384","https://openalex.org/W2305207049","https://openalex.org/W2328176404","https://openalex.org/W2346265746","https://openalex.org/W2549173848","https://openalex.org/W2587139789","https://openalex.org/W2594645799","https://openalex.org/W2611705774","https://openalex.org/W2618113379","https://openalex.org/W2653993779","https://openalex.org/W6640275993","https://openalex.org/W6698344935","https://openalex.org/W6737017206"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"One":[0],"of":[1,11,22,25,33,86,95,109,124,135,139,149,156,185,204,225,235,237],"the":[2,8,18,23,66,84,110,150,159,183,186,195,197,205,219],"methods":[3],"widely":[4],"used":[5,121,153],"to":[6,69,82,162,172,212],"measure":[7],"proliferative":[9],"activity":[10],"cells":[12,26],"in":[13,73,98,189,218,246],"breast":[14,96,127],"cancer":[15,97,128],"patients":[16,157],"is":[17,40],"immunohistochemical":[19],"(IHC)":[20],"measurement":[21],"percentage":[24],"stained":[27],"for":[28],"nuclear":[29],"antigen":[30],"Ki-67.":[31],"Use":[32],"Ki-67":[34,55,75,87,116,177,217,238],"expression":[35,88],"as":[36,158],"a":[37,53,105,122,133,154,167,232],"prognostic":[38],"marker":[39],"still":[41],"under":[42],"investigation.":[43],"However,":[44],"numerous":[45],"clinical":[46],"studies":[47],"have":[48,78],"reported":[49],"an":[50,190,223],"association":[51,85,236],"between":[52,112],"high":[54,174,214],"and":[56,60,115,141,146,165,179,240],"overall":[57],"survival":[58,63],"(OS)":[59],"disease":[61],"free":[62],"(DFS).":[64],"On":[65],"other":[67],"hand,":[68],"offer":[70],"non-invasive":[71],"alternative":[72],"determining":[74],"expression,":[76],"researchers":[77],"made":[79],"recent":[80],"attempts":[81],"study":[83],"with":[89,222],"magnetic":[90],"resonance":[91],"(MR)":[92],"imaging":[93,113,137,242],"features":[94,114,138,164,243],"small":[99],"cohorts":[100],"(<30).":[101],"Here,":[102],"we":[103,120,131,181],"present":[104],"large":[106],"scale":[107],"evaluation":[108],"relationship":[111],"score":[117],"as:":[118],"(a)":[119],"set":[123,134,161,193,221],"450":[125],"invasive":[126],"patients,":[129,151],"(b)":[130],"extracted":[132],"529":[136],"shape":[140],"enhancement":[142],"from":[143],"breast,":[144],"tumor":[145],"fibroglandular":[147],"tissue":[148],"(c)":[152],"subset":[155],"training":[160],"select":[163],"trained":[166,187],"multivariate":[168],"logistic":[169],"regression":[170],"model":[171,188,209],"predict":[173,213],"versus":[175,215],"low":[176,216],"values,":[178],"(d)":[180],"validated":[182],"performance":[184],"independent":[191],"test":[192,220],"using":[194],"area-under":[196],"receiver":[198],"operating":[199],"characteristics":[200],"(ROC)":[201],"curve":[202],"(AUC)":[203],"values":[206,239],"predicted.":[207],"Our":[208],"was":[210,244],"able":[211],"AUC":[224],"0.67":[226],"(95%":[227],"CI:":[228],"0.58-0.75,":[229],"p<1.1e-04).":[230],"Thus,":[231],"moderate":[233],"strength":[234],"MRextracted":[241],"demonstrated":[245],"our":[247],"experiments.":[248]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}