{"id":"https://openalex.org/W2789522356","doi":"https://doi.org/10.1117/12.2292210","title":"3D human lung histology reconstruction and registration to in vivo imaging","display_name":"3D human lung histology reconstruction and registration to in vivo imaging","publication_year":2018,"publication_date":"2018-03-06","ids":{"openalex":"https://openalex.org/W2789522356","doi":"https://doi.org/10.1117/12.2292210","mag":"2789522356"},"language":"en","primary_location":{"id":"doi:10.1117/12.2292210","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2292210","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Digital Pathology","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101541529","display_name":"Carol Johnson","orcid":"https://orcid.org/0009-0008-1242-6339"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carol Johnson","raw_affiliation_strings":["London Regional Cancer Program (Canada)"],"affiliations":[{"raw_affiliation_string":"London Regional Cancer Program (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073290406","display_name":"Mark Landis","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Landis","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059100369","display_name":"Richard Inculet","orcid":"https://orcid.org/0000-0002-5437-7378"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Inculet","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069900995","display_name":"Richard Malthaner","orcid":"https://orcid.org/0000-0002-3763-4838"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Malthaner","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112247218","display_name":"Dalilah Fortin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dalilah Fortin","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032441898","display_name":"George Rodrigues","orcid":"https://orcid.org/0000-0002-7174-4280"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George B. Rodrigues","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057971434","display_name":"Brian Yaremko","orcid":"https://orcid.org/0000-0002-5055-9027"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian P. Yaremko","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090288280","display_name":"David A. Palma","orcid":"https://orcid.org/0000-0002-9542-0627"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Palma","raw_affiliation_strings":["London Regional Cancer Program (Canada)","Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"London Regional Cancer Program (Canada)","institution_ids":[]},{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047863717","display_name":"Sarah A. Mattonen","orcid":"https://orcid.org/0000-0002-8172-1074"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah A. Mattonen","raw_affiliation_strings":["London Regional Cancer Program (Canada)","Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"London Regional Cancer Program (Canada)","institution_ids":[]},{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113914224","display_name":"Aaron D. Ward","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron D. Ward","raw_affiliation_strings":["London Regional Cancer Program (Canada)","Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"London Regional Cancer Program (Canada)","institution_ids":[]},{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038486476","display_name":"Alexander V. Louie","orcid":"https://orcid.org/0000-0002-3569-9099"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander  V. Louie","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097731073","display_name":"Sean Pentinga","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Pentinga","raw_affiliation_strings":["London Regional Cancer Program (Canada)","Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"London Regional Cancer Program (Canada)","institution_ids":[]},{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112124376","display_name":"Keith Kwan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Kwan","raw_affiliation_strings":["Western Univ. (Canada)"],"affiliations":[{"raw_affiliation_string":"Western Univ. (Canada)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5101541529"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5304,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66772497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":null,"first_page":"30","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.5635454654693604},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5184870958328247},{"id":"https://openalex.org/keywords/histology","display_name":"Histology","score":0.49901533126831055},{"id":"https://openalex.org/keywords/human-lung","display_name":"Human lung","score":0.4795946180820465},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4664228558540344},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4571104645729065},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41754305362701416},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.40444475412368774},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3470364511013031},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.3349137604236603},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2435290813446045},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.18389612436294556},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11461260914802551},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06311726570129395}],"concepts":[{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.5635454654693604},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5184870958328247},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.49901533126831055},{"id":"https://openalex.org/C2779744229","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Human lung","level":3,"score":0.4795946180820465},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4664228558540344},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4571104645729065},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41754305362701416},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.40444475412368774},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3470364511013031},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3349137604236603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2435290813446045},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18389612436294556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11461260914802551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06311726570129395},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2292210","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2292210","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Digital Pathology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1973064815","https://openalex.org/W1977792423","https://openalex.org/W2053512878","https://openalex.org/W2124735791","https://openalex.org/W2138707703","https://openalex.org/W2207540049","https://openalex.org/W2604796850","https://openalex.org/W6643597165","https://openalex.org/W6664056110","https://openalex.org/W6670966427","https://openalex.org/W6735761233"],"related_works":["https://openalex.org/W2399181824","https://openalex.org/W1497328854","https://openalex.org/W4292630483","https://openalex.org/W1953524262","https://openalex.org/W2312694297","https://openalex.org/W3178448014","https://openalex.org/W2626679715","https://openalex.org/W3040972647","https://openalex.org/W4238998491","https://openalex.org/W2417357751"],"abstract_inverted_index":{"Stereotactic":[0],"ablative":[1],"radiotherapy":[2,6],"(SABR)":[3],"delivers":[4],"high-dose-per-fraction":[5],"to":[7,52,68,91,147,207,220,228,234],"tumours":[8],"and":[9,36,86,96,144,165,188,246],"spares":[10],"surrounding":[11],"tissue.":[12],"It":[13],"is":[14,205],"effective":[15],"for":[16,159,169,199,242],"early-stage":[17],"non-small":[18],"cell":[19],"lung":[20,26,212,244],"cancer.":[21],"However,":[22,47],"SABR":[23],"causes":[24],"radiationinduced":[25],"injuries":[27],"that":[28,203],"mimic":[29],"recurring":[30],"cancer,":[31],"confounding":[32],"detection":[33],"of":[34,58,74,88,125,151,180,185,192],"recurrences":[35],"early":[37],"salvage":[38],"therapy.":[39],"We":[40,176],"have":[41],"previously":[42],"developed":[43,132],"radiomics-based":[44],"recurrence":[45],"detection.":[46],"our":[48,65,131],"radiomics":[49,247],"system":[50],"needs":[51],"be":[53],"validated":[54],"against":[55],"histologic":[56,243],"markers":[57],"viable":[59],"tumour":[60],"post-SABR.":[61],"In":[62],"this":[63,236],"paper,":[64],"goals":[66],"were":[67,111],"develop":[69],"semiautomatic":[70],"(1)":[71],"2D":[72],"reconstruction":[73,85,143],"pseudo":[75],"whole-mount":[76],"(PWM)":[77],"tissue":[78,103],"sections":[79,90,104,127],"from":[80,113,173],"scanned":[81],"slides,":[82],"(2)":[83],"3D":[84,133,141],"registration":[87,99,157],"PWM":[89,142],"pre-surgery":[92],"computed":[93],"tomography":[94],"(CT),":[95],"(3)":[97],"quantitative":[98],"error":[100,158],"measurement.":[101],"Lobectomy":[102],"on":[105],"standard":[106,183],"1\u201d":[107],"\u00d7":[108],"3\u201d":[109],"slides":[110],"obtained":[112],"patients":[114],"who":[115],"underwent":[116],"SABR.":[117],"Our":[118],"graphical":[119],"user":[120],"interface":[121],"allows":[122],"interactive":[123],"stitching":[124],"the":[126,200,221],"into":[128],"PWMs.":[129],"Using":[130],"Slicer-based":[134],"thin-plate":[135],"spline":[136],"warping":[137],"tool,":[138],"we":[139],"performed":[140],"registered":[145],"them":[146],"CT":[148,213],"via":[149],"correspondence":[150],"homologous":[152],"intrinsic":[153],"landmarks.":[154],"The":[155],"target":[156],"229":[160],"fiducial":[161],"pairs":[162],"defining":[163],"vessels":[164],"airways":[166],"was":[167],"calculated":[168],"56":[170],"PWMs":[171],"reconstructed":[172],"9":[174],"patients.":[175],"measured":[177],"a":[178,240],"mean":[179,190],"7.33":[181],"mm,":[182],"deviation":[184],"4.59":[186],"mm":[187],"root":[189],"square":[191],"8.65":[193],"mm.":[194],"This":[195],"proof-of-principle":[196],"study":[197],"demonstrates":[198],"first":[201],"time":[202],"it":[204],"feasible":[206],"register":[208],"in":[209],"vivo":[210],"human":[211],"images":[214],"with":[215,217],"histology,":[216],"no":[218],"modifications":[219],"clinical":[222],"pathology":[223],"workflow":[224],"other":[225],"than":[226],"videography":[227],"document":[229],"gross":[230],"dissection.":[231],"Ongoing":[232],"work":[233],"automate":[235],"process":[237],"will":[238],"yield":[239],"tool":[241],"imaging":[245],"validation.":[248]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
