{"id":"https://openalex.org/W2792180765","doi":"https://doi.org/10.1117/12.2291898","title":"Evaluation of chemotherapeutic response of temozolomide in orthotopic glioma using bioluminescence tomography","display_name":"Evaluation of chemotherapeutic response of temozolomide in orthotopic glioma using bioluminescence tomography","publication_year":2018,"publication_date":"2018-03-12","ids":{"openalex":"https://openalex.org/W2792180765","doi":"https://doi.org/10.1117/12.2291898","mag":"2792180765"},"language":"en","primary_location":{"id":"doi:10.1117/12.2291898","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2291898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100361219","display_name":"Li Li","orcid":"https://orcid.org/0000-0002-6789-2328"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Li","raw_affiliation_strings":["Institute of Automation (China)","Soochow Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]},{"raw_affiliation_string":"Soochow Univ. (China)","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114062332","display_name":"Yang Du","orcid":"https://orcid.org/0000-0002-1564-1842"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Du","raw_affiliation_strings":["Institute of Automation (China)","Univ. of Chinese Academy of Sciences (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]},{"raw_affiliation_string":"Univ. of Chinese Academy of Sciences (China)","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079807652","display_name":"Xinjian Chen","orcid":"https://orcid.org/0000-0002-0871-293X"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjian Chen","raw_affiliation_strings":["Soochow Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Soochow Univ. (China)","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112284258","display_name":"Jie Tian","orcid":"https://orcid.org/0009-0001-7785-849X"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Tian","raw_affiliation_strings":["Institute of Automation (China)","Univ. of Chinese Academy of Sciences (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]},{"raw_affiliation_string":"Univ. of Chinese Academy of Sciences (China)","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067837028","display_name":"Jinzuo Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinzuo Ye","raw_affiliation_strings":["Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031688232","display_name":"Dehui Xiang","orcid":"https://orcid.org/0000-0001-7873-9778"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dehui Xiang","raw_affiliation_strings":["Soochow Univ. (China)"],"affiliations":[{"raw_affiliation_string":"Soochow Univ. (China)","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100361219"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210094879"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02227483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temozolomide","display_name":"Temozolomide","score":0.9225085973739624},{"id":"https://openalex.org/keywords/bioluminescence","display_name":"Bioluminescence","score":0.8432625532150269},{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.6535681486129761},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"Bioluminescence imaging","score":0.5741804838180542},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.47911643981933594},{"id":"https://openalex.org/keywords/chemotherapeutic-drugs","display_name":"Chemotherapeutic drugs","score":0.41256505250930786},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.40309590101242065},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.2515428364276886},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2501717805862427},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1736118197441101},{"id":"https://openalex.org/keywords/luciferase","display_name":"Luciferase","score":0.11058315634727478},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.05868139863014221},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.05383729934692383}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.9225085973739624},{"id":"https://openalex.org/C5176359","wikidata":"https://www.wikidata.org/wiki/Q179924","display_name":"Bioluminescence","level":2,"score":0.8432625532150269},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6535681486129761},{"id":"https://openalex.org/C161997846","wikidata":"https://www.wikidata.org/wiki/Q4915066","display_name":"Bioluminescence imaging","level":5,"score":0.5741804838180542},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47911643981933594},{"id":"https://openalex.org/C3020391286","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapeutic drugs","level":3,"score":0.41256505250930786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40309590101242065},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2515428364276886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2501717805862427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1736118197441101},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.11058315634727478},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.05868139863014221},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.05383729934692383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2291898","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2291898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2019265097","https://openalex.org/W2023949269","https://openalex.org/W2042907121","https://openalex.org/W2059246878","https://openalex.org/W2092068110","https://openalex.org/W2146018860"],"related_works":["https://openalex.org/W4386495842","https://openalex.org/W4386758351","https://openalex.org/W1964907928","https://openalex.org/W4367366364","https://openalex.org/W165594268","https://openalex.org/W2763473976","https://openalex.org/W2393510792","https://openalex.org/W2065552391","https://openalex.org/W4255858473","https://openalex.org/W2423084403"],"abstract_inverted_index":{"Glioma":[0],"is":[1,15,31,164],"one":[2],"of":[3,9,52,119,179,209],"the":[4,37,50,67,77,88,92,100,104,110,128,131,153,177,180,185,197,207,219,239],"most":[5],"important":[6],"leading":[7],"causes":[8],"cancer-related":[10],"deaths":[11],"worldwide.":[12],"Temozolomide":[13,116],"(TMZ)":[14],"a":[16],"DNA":[17],"methylating":[18],"agent":[19],"that":[20,206],"presents":[21],"promising":[22],"antitumor":[23],"activity":[24],"against":[25],"high":[26],"grade":[27],"glioma.":[28],"However,":[29],"there":[30],"no":[32],"effective":[33],"way":[34],"to":[35,40,175,193],"assess":[36],"therapeutic":[38,154],"response":[39],"TMZ":[41,53,101,111,220,235],"at":[42,139],"early":[43,216],"stage.":[44],"In":[45],"this":[46,203],"study,":[47],"we":[48],"evaluated":[49],"efficacy":[51,222],"on":[54,62],"brain":[55,80],"tumor":[56,81,89,240],"through":[57],"bioluminescence":[58,143,167],"tomography":[59,168],"(BLT)":[60],"based":[61],"multi-modality":[63],"imaging":[64,144],"system.":[65],"Initially,":[66],"human":[68],"glioma":[69,210],"cell":[70,90],"line":[71],"U87MG-fLuc":[72],"cells":[73],"were":[74,94,113,134,173,191],"cultured,":[75],"and":[76,103,127,183,188,218,226],"orthotopic":[78],"mouse":[79],"model":[82],"was":[83,146],"established.":[84],"10":[85],"days":[86,150],"after":[87],"implantation,":[91],"mice":[93,108,129],"divided":[95],"into":[96],"two":[97],"groups":[98],"including":[99],"group":[102,112,133],"control":[105,132],"group.":[106],"The":[107,142,200],"in":[109,130,202],"treated":[114,135],"with":[115,117,136],"dosage":[118],"50":[120],"mg/kg/day":[121],"intraperitoneally":[122],"for":[123,151,166],"continuous":[124],"6":[125],"days,":[126],"sterile":[137],"saline":[138],"equal":[140],"volume.":[141],"(BLI)":[145],"acquired":[147,192],"every":[148],"5":[149],"monitoring":[152],"responses.":[155],"A":[156],"randomly":[157],"enhanced":[158],"adaptive":[159],"subspace":[160],"pursuit":[161],"(REASP)":[162],"algorithm":[163],"presented":[165],"reconstruction.":[169],"Basically,":[170],"numerical":[171],"experiments":[172],"used":[174],"validate":[176],"efficiency":[178],"proposed":[181],"method,":[182],"then":[184],"mice\u2019s":[186],"CT":[187],"BLI":[189],"data":[190,233],"reconstruct":[194],"BLT":[195,230],"using":[196,229],"REASP":[198],"algorithm.":[199],"results":[201],"study":[204],"showed":[205],"growth":[208],"can":[211,223,236],"be":[212,224],"monitored":[213],"from":[214],"very":[215],"stage,":[217],"treatment":[221],"reliably":[225],"objectively":[227],"assessed":[228],"method.":[231],"Our":[232],"demonstrated":[234],"effectively":[237],"inhibit":[238],"growth.":[241]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
