{"id":"https://openalex.org/W2596917532","doi":"https://doi.org/10.1117/12.2254849","title":"Improving graph-based OCT segmentation for severe pathology in retinitis pigmentosa patients","display_name":"Improving graph-based OCT segmentation for severe pathology in retinitis pigmentosa patients","publication_year":2017,"publication_date":"2017-03-13","ids":{"openalex":"https://openalex.org/W2596917532","doi":"https://doi.org/10.1117/12.2254849","mag":"2596917532","pmid":"https://pubmed.ncbi.nlm.nih.gov/28781413"},"language":"en","primary_location":{"id":"doi:10.1117/12.2254849","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254849","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5540322","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103480360","display_name":"Andrew Lang","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew Lang","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075622613","display_name":"Aaron Carass","orcid":"https://orcid.org/0000-0003-4939-5085"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Carass","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058421098","display_name":"Ava K. Bittner","orcid":"https://orcid.org/0000-0002-9498-2230"},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ava K. Bittner","raw_affiliation_strings":["Nova Southeastern Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Nova Southeastern Univ. (United States)","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108447802","display_name":"Howard S. Ying","orcid":null},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard S. Ying","raw_affiliation_strings":["Boston Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Boston Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066682675","display_name":"Jerry L. Prince","orcid":"https://orcid.org/0000-0002-6553-0876"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry L. Prince","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103480360"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":1.119,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76753793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10137","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"Retinitis pigmentosa","score":0.776423990726471},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5537923574447632},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5147204995155334},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.48865726590156555},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4567486047744751},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.41860339045524597},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.41522693634033203},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3611869513988495},{"id":"https://openalex.org/keywords/optometry","display_name":"Optometry","score":0.334025114774704},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.27455952763557434},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.05674108862876892}],"concepts":[{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.776423990726471},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5537923574447632},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5147204995155334},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.48865726590156555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4567486047744751},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.41860339045524597},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.41522693634033203},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3611869513988495},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.334025114774704},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.27455952763557434},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.05674108862876892}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2254849","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254849","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:28781413","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28781413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5540322","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5540322","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5540322","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5540322","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2006073837","https://openalex.org/W2011237852","https://openalex.org/W2013107002","https://openalex.org/W2024492357","https://openalex.org/W2035311875","https://openalex.org/W2038850290","https://openalex.org/W2060040689","https://openalex.org/W2070162220","https://openalex.org/W2070346824","https://openalex.org/W2079390326","https://openalex.org/W2079413294","https://openalex.org/W2127318120","https://openalex.org/W2164774194","https://openalex.org/W2293393758","https://openalex.org/W2911964244","https://openalex.org/W6659316305","https://openalex.org/W6696838010"],"related_works":["https://openalex.org/W2041896872","https://openalex.org/W4205637362","https://openalex.org/W2402796057","https://openalex.org/W4233329698","https://openalex.org/W584015088","https://openalex.org/W2040119765","https://openalex.org/W7340977","https://openalex.org/W2029841208","https://openalex.org/W2284557216","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Three":[0],"dimensional":[1],"segmentation":[2,33,55],"of":[3,10,24,34,60,80,119,134,142,168],"macular":[4],"optical":[5],"coherence":[6],"tomography":[7],"(OCT)":[8],"data":[9,36,71,101,157],"subjects":[11,161],"with":[12],"retinitis":[13],"pigmentosa":[14],"(RP)":[15],"is":[16,95,152],"a":[17,50,91,110],"challenging":[18],"problem":[19],"due":[20],"to":[21,37,49,57,102,114,127,173],"the":[22,25,76,99,116,124,128,177],"disappearance":[23],"photoreceptor":[26],"layers,":[27],"which":[28,106],"causes":[29],"algorithms":[30],"developed":[31,52],"for":[32],"healthy":[35,85,135],"perform":[38],"poorly":[39],"on":[40,75,98,156],"RP":[41,61,70,100,145],"patients.":[42],"In":[43],"this":[44],"work,":[45,90],"we":[46],"present":[47],"enhancements":[48],"previously":[51],"graph-based":[53],"OCT":[54],"pipeline":[56],"enable":[58],"processing":[59],"data.":[62,86,125],"The":[63],"algorithm":[64,113],"segments":[65],"eight":[66],"retinal":[67],"layers":[68,133,138],"in":[69,139,144],"by":[72,109],"relaxing":[73],"constraints":[74],"thickness":[77],"and":[78,137],"smoothness":[79],"each":[81],"layer":[82],"learned":[83],"from":[84,88,159],"Following":[87],"prior":[89],"random":[92],"forest":[93],"classifier":[94],"first":[96],"trained":[97],"estimate":[103],"boundary":[104,166],"probabilities,":[105],"are":[107],"used":[108],"graph":[111],"search":[112],"find":[115],"optimal":[117],"set":[118],"nine":[120,160],"surfaces":[121],"that":[122],"fit":[123],"Due":[126],"intensity":[129,149],"disparity":[130],"between":[131],"normal":[132],"controls":[136],"various":[140],"stages":[141],"degeneration":[143],"patients,":[146],"an":[147,163],"additional":[148],"normalization":[150],"step":[151],"introduced.":[153],"Leave-one-out":[154],"validation":[155],"acquired":[158],"showed":[162],"average":[164],"overall":[165],"error":[167],"4.22":[169],"\u03bcm":[170,175],"as":[171],"compared":[172],"6.02":[174],"using":[176],"original":[178],"algorithm.":[179]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}