{"id":"https://openalex.org/W2592475027","doi":"https://doi.org/10.1117/12.2254428","title":"Multi-modal and targeted imaging improves automated mid-brain segmentation","display_name":"Multi-modal and targeted imaging improves automated mid-brain segmentation","publication_year":2017,"publication_date":"2017-02-24","ids":{"openalex":"https://openalex.org/W2592475027","doi":"https://doi.org/10.1117/12.2254428","mag":"2592475027","pmid":"https://pubmed.ncbi.nlm.nih.gov/28781412"},"language":"en","primary_location":{"id":"doi:10.1117/12.2254428","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254428","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060185946","display_name":"Andrew J. Plassard","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Plassard","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108952718","display_name":"Pierre D\u2019Haese","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre F. D\u2019Haese","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112829343","display_name":"Srivatsan Pallavaram","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srivatsan Pallavaram","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086482403","display_name":"Allen T. Newton","orcid":"https://orcid.org/0000-0001-6539-8783"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen T. Newton","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064135529","display_name":"Daniel O. Claassen","orcid":"https://orcid.org/0000-0002-9853-4902"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel O. Claassen","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014896512","display_name":"Beno\u00eet M. Dawant","orcid":"https://orcid.org/0000-0002-3804-8400"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benoit M. Dawant","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075735203","display_name":"Bennett A. Landman","orcid":"https://orcid.org/0000-0001-5733-2127"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett A. Landman","raw_affiliation_strings":["Vanderbilt Univ. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ. (United States)","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":3.4888,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.90342298,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"10133","issue":null,"first_page":"101330J","last_page":"101330J"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/putamen","display_name":"Putamen","score":0.7080089449882507},{"id":"https://openalex.org/keywords/globus-pallidus","display_name":"Globus pallidus","score":0.7067510485649109},{"id":"https://openalex.org/keywords/thalamus","display_name":"Thalamus","score":0.5795512199401855},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.46935635805130005},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"Caudate nucleus","score":0.4681333005428314},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"Basal ganglia","score":0.4586089253425598},{"id":"https://openalex.org/keywords/s\u00f8rensen\u2013dice-coefficient","display_name":"S\u00f8rensen\u2013Dice coefficient","score":0.4375638961791992},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34047427773475647},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3296881914138794},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.32316774129867554},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3124796152114868},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.28590303659439087},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26978152990341187},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.23544177412986755},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20030274987220764},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.1105872094631195}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.7080089449882507},{"id":"https://openalex.org/C2780278869","wikidata":"https://www.wikidata.org/wiki/Q1759633","display_name":"Globus pallidus","level":4,"score":0.7067510485649109},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.5795512199401855},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.46935635805130005},{"id":"https://openalex.org/C2781423529","wikidata":"https://www.wikidata.org/wiki/Q1132309","display_name":"Caudate nucleus","level":2,"score":0.4681333005428314},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.4586089253425598},{"id":"https://openalex.org/C163892561","wikidata":"https://www.wikidata.org/wiki/Q2613728","display_name":"S\u00f8rensen\u2013Dice coefficient","level":4,"score":0.4375638961791992},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34047427773475647},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3296881914138794},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.32316774129867554},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3124796152114868},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.28590303659439087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26978152990341187},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.23544177412986755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20030274987220764},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1105872094631195}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2254428","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254428","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:28781412","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28781412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:4385708","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5544135","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"awards":[{"id":"https://openalex.org/G1469139258","display_name":null,"funder_award_id":"#UL1 TR000445","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G534696910","display_name":null,"funder_award_id":"R01 NS095291","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7697714081","display_name":null,"funder_award_id":"R01-EB006136","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G949362299","display_name":null,"funder_award_id":"UL1-RR024975","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G961665540","display_name":null,"funder_award_id":"T32 LM012412","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W4044073","https://openalex.org/W904184522","https://openalex.org/W1513126258","https://openalex.org/W1667869507","https://openalex.org/W1967619230","https://openalex.org/W1983297775","https://openalex.org/W2014736310","https://openalex.org/W2018379779","https://openalex.org/W2031170958","https://openalex.org/W2050567029","https://openalex.org/W2055576639","https://openalex.org/W2071546430","https://openalex.org/W2073449985","https://openalex.org/W2075021671","https://openalex.org/W2085091083","https://openalex.org/W2100209835","https://openalex.org/W2119578333","https://openalex.org/W2136145485","https://openalex.org/W2160124809","https://openalex.org/W2315387241","https://openalex.org/W2417577768","https://openalex.org/W2883307921","https://openalex.org/W4238080190","https://openalex.org/W4297067014","https://openalex.org/W6600163142","https://openalex.org/W6683598927","https://openalex.org/W6699630433","https://openalex.org/W6716451884"],"related_works":["https://openalex.org/W161201599","https://openalex.org/W1872183301","https://openalex.org/W2162561353","https://openalex.org/W2132636956","https://openalex.org/W55748174","https://openalex.org/W2379929261","https://openalex.org/W4389237840","https://openalex.org/W2190703979","https://openalex.org/W2131980136","https://openalex.org/W3030121363"],"abstract_inverted_index":{"The":[0],"basal":[1],"ganglia":[2],"and":[3,11,17,40,67,114,132,140,155,165,173,188,196,205,227],"limbic":[4],"system,":[5],"particularly":[6],"the":[7,123,130,163,193,217],"thalamus,":[8],"putamen,":[9,133],"internal":[10,164],"external":[12,166],"globus":[13,167],"pallidus,":[14],"substantia":[15,194],"nigra,":[16],"sub-thalamic":[18,197],"nucleus,":[19],"comprise":[20],"a":[21,36,80,92,110,134,141,151,169,174,184,199,206],"clinically":[22],"relevant":[23],"signal":[24],"network":[25],"for":[26],"Parkinson's":[27],"disease.":[28],"In":[29,86,129,162,192],"order":[30],"to":[31,52,102],"manually":[32],"trace":[33],"these":[34,84,105],"structures,":[35],"combination":[37,111,152,185],"of":[38,83,94,112,153,186,202,210],"high-resolution":[39],"specialized":[41],"sequences":[42,61],"at":[43,62,97,107],"7T":[44,98],"are":[45],"used,":[46],"but":[47],"it":[48],"is":[49],"not":[50],"feasible":[51],"scan":[53],"clinical":[54],"patients":[55],"in":[56,79],"those":[57],"scanners.":[58],"Targeted":[59],"imaging":[60,116,160,190,221],"3T":[63,108],"such":[64],"as":[65],"F-GATIR,":[66],"other":[68],"optimized":[69,115,157,218,228],"inversion":[70,158,219,229],"recovery":[71,159,220,230],"sequences,":[72,117],"have":[73],"been":[74],"presented":[75],"which":[76],"enhance":[77],"contrast":[78],"select":[81],"group":[82],"structures.":[85,128],"this":[87],"work,":[88],"we":[89],"show":[90],"that":[91],"series":[93],"atlases":[95],"generated":[96],"can":[99],"be":[100],"used":[101],"accurately":[103],"segment":[104],"structures":[106],"using":[109,150,183,216,225],"standard":[113],"though":[118],"no":[119],"one":[120],"approach":[121],"provided":[122],"best":[124],"result":[125],"across":[126],"all":[127],"thalamus":[131],"median":[135],"Dice":[136,170,200],"coefficient":[137,201],"over":[138,171,203],"0.88":[139],"mean":[142,175,207],"surface":[143,176,208],"distance":[144,177,209],"less":[145,178,211],"than":[146,179,212,237],"1.0mm":[147,213],"was":[148,181,214],"achieved":[149,182,215],"T1":[154,187,226],"an":[156],"sequences.":[161,191],"pallidus":[168],"0.75":[172],"1.2mm":[180],"F-GATIR":[189],"nigra":[195],"nucleus":[198],"0.6":[204],"sequence.":[222],"On":[223],"average,":[224],"together":[231],"produced":[232],"significantly":[233],"improved":[234],"segmentation":[235],"results":[236],"any":[238],"individual":[239],"modality":[240],"(p<0.05":[241],"wilcox":[242],"sign-rank":[243],"test).":[244]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
