{"id":"https://openalex.org/W2597085145","doi":"https://doi.org/10.1117/12.2254337","title":"Phenotypic feature quantification of patient derived 3D cancer spheroids in fluorescence microscopy image","display_name":"Phenotypic feature quantification of patient derived 3D cancer spheroids in fluorescence microscopy image","publication_year":2017,"publication_date":"2017-03-13","ids":{"openalex":"https://openalex.org/W2597085145","doi":"https://doi.org/10.1117/12.2254337","mag":"2597085145"},"language":"en","primary_location":{"id":"doi:10.1117/12.2254337","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254337","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033767830","display_name":"Mi-Sun Kang","orcid":"https://orcid.org/0000-0002-4836-5805"},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Mi-Sun Kang","raw_affiliation_strings":["Ewha Womans Univ. (Korea, Republic of)"],"affiliations":[{"raw_affiliation_string":"Ewha Womans Univ. (Korea, Republic of)","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020419830","display_name":"Seon-Min Rhee","orcid":null},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seon-Min Rhee","raw_affiliation_strings":["Samsung Advanced Institute of Technology (Korea, Republic of)"],"affiliations":[{"raw_affiliation_string":"Samsung Advanced Institute of Technology (Korea, Republic of)","institution_ids":["https://openalex.org/I2250650973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101505359","display_name":"Jihyun Seo","orcid":"https://orcid.org/0000-0002-8343-2356"},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Hyun Seo","raw_affiliation_strings":["Ewha Womans Univ. (Korea, Republic of)"],"affiliations":[{"raw_affiliation_string":"Ewha Womans Univ. (Korea, Republic of)","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053436629","display_name":"Myoung\u2010Hee Kim","orcid":"https://orcid.org/0000-0003-1254-7743"},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myoung-Hee Kim","raw_affiliation_strings":["Ewha Womans Univ. (Korea, Republic of)"],"affiliations":[{"raw_affiliation_string":"Ewha Womans Univ. (Korea, Republic of)","institution_ids":["https://openalex.org/I138925566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033767830"],"corresponding_institution_ids":["https://openalex.org/I138925566"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01997583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10137","issue":null,"first_page":"101370U","last_page":"101370U"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.6859176158905029},{"id":"https://openalex.org/keywords/spheroid","display_name":"Spheroid","score":0.6813626885414124},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.606452465057373},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5283145308494568},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5232842564582825},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.4889756441116333},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3888276517391205},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3421708941459656},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2992345690727234},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2374989092350006},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21956178545951843},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1869398057460785},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.15408402681350708},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12909704446792603},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.07378223538398743}],"concepts":[{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.6859176158905029},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.6813626885414124},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.606452465057373},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5283145308494568},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5232842564582825},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4889756441116333},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3888276517391205},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3421708941459656},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2992345690727234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2374989092350006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21956178545951843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1869398057460785},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.15408402681350708},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12909704446792603},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.07378223538398743},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2254337","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254337","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6200000047683716}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1906463780","https://openalex.org/W1967005434","https://openalex.org/W1974402712","https://openalex.org/W2080971197","https://openalex.org/W2092853008","https://openalex.org/W2107554012","https://openalex.org/W2244130513","https://openalex.org/W2341721391","https://openalex.org/W3122598275","https://openalex.org/W4206451900","https://openalex.org/W4233313529","https://openalex.org/W6640113749"],"related_works":["https://openalex.org/W4211107619","https://openalex.org/W2161433272","https://openalex.org/W2894139091","https://openalex.org/W1637909","https://openalex.org/W1983780159","https://openalex.org/W659245948","https://openalex.org/W2793462084","https://openalex.org/W2094643072","https://openalex.org/W2087957833","https://openalex.org/W4206210906"],"abstract_inverted_index":{"Patients\u2019":[0],"responses":[1,23],"to":[2,28,36,117,196,201],"a":[3,29],"drug":[4],"differ":[5],"at":[6,74],"the":[7,22,38,50,65,75,90,99,105,109,119,130,138,147,153,159,176,182,198,202],"cellular":[8,68],"level.":[9],"Here,":[10],"we":[11,84,136,157],"present":[12],"an":[13],"image-based":[14,86,191],"cell":[15,72],"phenotypic":[16,87,192],"feature":[17],"quantification":[18],"method":[19],"for":[20,64,129,190],"predicting":[21],"of":[24,40,67,89,92,101,104,132,140,146,150,194],"patient-derived":[25,41,93],"glioblastoma":[26],"cells":[27,151,166,174,195],"particular":[30],"drug.":[31,203],"We":[32,96,112],"used":[33,114,128],"high-content":[34],"imaging":[35],"understand":[37],"features":[39],"cancer":[42,94],"cells.":[43,95],"A":[44],"3D":[45,163],"spheroid":[46,164],"culture":[47,165,173],"formation":[48],"resembles":[49],"in":[51,152],"vivo":[52],"environment":[53],"more":[54,79],"closely":[55],"than":[56],"2D":[57,171],"adherent":[58,172],"cultures":[59],"do,":[60],"and":[61,124],"it":[62],"allows":[63],"observation":[66],"aggregate":[69],"characteristics.":[70],"However,":[71],"analysis":[73],"individual":[76,133],"level":[77],"is":[78,144],"challenging.":[80],"In":[81],"this":[82],"paper,":[83],"demonstrate":[85],"screening":[88,193],"nuclei":[91],"first":[97],"stitched":[98],"images":[100],"each":[102,141],"well":[103,154],"384-well":[106],"plate":[107],"with":[108,167,181],"same":[110,177,183],"state.":[111],"then":[113],"intensity":[115,123],"information":[116],"detect":[118],"colonies.":[120],"The":[121],"nuclear":[122],"morphological":[125],"characteristics":[126],"were":[127],"segmentation":[131],"nuclei.":[134],"Next,":[135],"calculated":[137],"position":[139],"nucleus":[142],"that":[143],"appeal":[145],"spatial":[148],"pattern":[149],"environment.":[155],"Finally,":[156],"compared":[158],"results":[160],"obtained":[161,169],"using":[162,170],"those":[168],"from":[175],"patient":[178],"being":[179],"treated":[180],"drugs.":[184],"This":[185],"technique":[186],"could":[187],"be":[188],"applied":[189],"determine":[197],"patient\u2019s":[199],"response":[200]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}