{"id":"https://openalex.org/W2596978875","doi":"https://doi.org/10.1117/12.2254323","title":"Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography","display_name":"Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography","publication_year":2017,"publication_date":"2017-03-13","ids":{"openalex":"https://openalex.org/W2596978875","doi":"https://doi.org/10.1117/12.2254323","mag":"2596978875"},"language":"en","primary_location":{"id":"doi:10.1117/12.2254323","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254323","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037382497","display_name":"Qian Liang","orcid":"https://orcid.org/0000-0003-2674-2136"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qian Liang","raw_affiliation_strings":["Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067837028","display_name":"Jinzuo Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinzuo Ye","raw_affiliation_strings":["Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114062332","display_name":"Yang Du","orcid":"https://orcid.org/0000-0002-1564-1842"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Du","raw_affiliation_strings":["Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103565505","display_name":"Chongwei Chi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongwei Chi","raw_affiliation_strings":["Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100429270","display_name":"Jie Tian","orcid":"https://orcid.org/0000-0003-0498-0432"},"institutions":[{"id":"https://openalex.org/I4210094879","display_name":"Shandong Institute of Automation","ror":"https://ror.org/00qdtba35","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210094879","https://openalex.org/I4210142748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Tian","raw_affiliation_strings":["Institute of Automation (China)"],"affiliations":[{"raw_affiliation_string":"Institute of Automation (China)","institution_ids":["https://openalex.org/I4210094879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5037382497"],"corresponding_institution_ids":["https://openalex.org/I4210094879"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02152719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10137","issue":null,"first_page":"1013702","last_page":"1013702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib","display_name":"Sorafenib","score":0.9364776611328125},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.77992844581604},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"Liver cancer","score":0.7314931750297546},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6988362669944763},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"Bioluminescence imaging","score":0.5722795128822327},{"id":"https://openalex.org/keywords/liver-tumor","display_name":"Liver tumor","score":0.5693228244781494},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5602667331695557},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.38526421785354614},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3597243130207062},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.28979116678237915},{"id":"https://openalex.org/keywords/transfection","display_name":"Transfection","score":0.23547783493995667},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1578134000301361},{"id":"https://openalex.org/keywords/luciferase","display_name":"Luciferase","score":0.11358407139778137}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.9364776611328125},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.77992844581604},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.7314931750297546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6988362669944763},{"id":"https://openalex.org/C161997846","wikidata":"https://www.wikidata.org/wiki/Q4915066","display_name":"Bioluminescence imaging","level":5,"score":0.5722795128822327},{"id":"https://openalex.org/C2776964913","wikidata":"https://www.wikidata.org/wiki/Q1671502","display_name":"Liver tumor","level":3,"score":0.5693228244781494},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5602667331695557},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38526421785354614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3597243130207062},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28979116678237915},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.23547783493995667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1578134000301361},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.11358407139778137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2254323","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2254323","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W156283619","https://openalex.org/W1973665900","https://openalex.org/W2002527017","https://openalex.org/W2004435739","https://openalex.org/W2028667086","https://openalex.org/W2059246878","https://openalex.org/W2070396671","https://openalex.org/W2147281055","https://openalex.org/W2917837889","https://openalex.org/W6606319029","https://openalex.org/W6651554870","https://openalex.org/W6759431858"],"related_works":["https://openalex.org/W2415536161","https://openalex.org/W2087356637","https://openalex.org/W2034139851","https://openalex.org/W3018861914","https://openalex.org/W4285206599","https://openalex.org/W2769323635","https://openalex.org/W1970460092","https://openalex.org/W4361816912","https://openalex.org/W4362622788","https://openalex.org/W2280419820"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1,26,40],"(HCC)":[2],"is":[3],"one":[4],"of":[5,11,22,118,164,209],"the":[6,20,37,54,73,78,90,98,103,109,129,132,162,177,198,204],"most":[7],"important":[8],"leading":[9],"causes":[10],"cancer-related":[12],"deaths":[13],"worldwide.":[14],"In":[15],"this":[16,158],"study,":[17],"we":[18],"evaluated":[19],"efficacy":[21,149,180,212],"sorafenib":[23,99,115,178,195],"on":[24,32,62,213],"hepatocellular":[25,39],"through":[27,153],"bioluminescence":[28],"tomography":[29],"(BLT)":[30],"based":[31],"Micro-CT/BLT":[33],"multi-modal":[34],"system.":[35],"Initially,":[36],"human":[38],"cell":[41,75],"line":[42],"HepG2-Red-FLuc,":[43],"which":[44],"was":[45,50,60],"transfected":[46],"with":[47,114,116,137],"luciferase":[48],"gene,":[49],"cultured.":[51],"And":[52],"then,":[53],"orthotopic":[55],"liver":[56,79,165,214],"tumor":[57,87,144,199],"mouse":[58],"model":[59],"established":[61],"4~5":[63],"weeks":[64],"old":[65],"athymic":[66],"male":[67],"Balb/c":[68],"nude":[69],"mice":[70,91,107,130],"by":[71,121],"inoculating":[72],"HepG2-Red-FLuc":[74],"suspension":[76],"into":[77,94],"lobe":[80],"under":[81],"isoflurane":[82],"anesthesia.":[83],"15~20":[84],"days":[85],"after":[86],"cells":[88],"implantation,":[89],"were":[92,112,135,150],"divided":[93],"two":[95],"groups":[96],"including":[97],"treatment":[100,110,148,179],"group":[101,111,134],"and":[102,128,146,175,184,206],"control":[104,133],"group.":[105],"The":[106,143,155],"in":[108,131,157],"treated":[113,136],"dosage":[117],"62":[119],"mg/kg/day":[120],"oral":[122],"gavage":[123],"for":[124],"continuous":[125],"14":[126],"days,":[127],"sterile":[138],"water":[139],"at":[140],"equal":[141],"volume.":[142],"growth":[145,163,200],"drug":[147,211],"dynamically":[151,169],"monitored":[152,170],"BLT.":[154],"results":[156],"study":[159],"showed":[160],"that":[161],"cancer":[166],"can":[167,181,196],"be":[168,182],"from":[171],"very":[172],"early":[173],"stage,":[174],"also":[176],"reliably":[183],"objectively":[185],"assessed":[186],"using":[187],"BLT":[188,202],"imaging":[189],"method.":[190],"Our":[191],"experimental":[192],"result":[193],"demonstrated":[194],"inhibit":[197],"effectively.":[201],"enabled":[203],"non-invasive":[205],"reliable":[207],"assessment":[208],"anti-neoplastic":[210],"cancer.":[215]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}