{"id":"https://openalex.org/W2605883003","doi":"https://doi.org/10.1117/12.2252282","title":"Spatial resolution properties of digital autoradiography systems for pre-clinical alpha particle imaging (Conference Presentation)","display_name":"Spatial resolution properties of digital autoradiography systems for pre-clinical alpha particle imaging (Conference Presentation)","publication_year":2017,"publication_date":"2017-04-19","ids":{"openalex":"https://openalex.org/W2605883003","doi":"https://doi.org/10.1117/12.2252282","mag":"2605883003"},"language":"en","primary_location":{"id":"doi:10.1117/12.2252282","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2252282","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034984232","display_name":"Jesse Tanguay","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I822440","display_name":"Okanagan University College","ror":"https://ror.org/02mxmh518","country_code":"CA","type":"education","lineage":["https://openalex.org/I822440"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jesse Tanguay","raw_affiliation_strings":["The Univ. of British Columbia Okanagan (Canada)"],"affiliations":[{"raw_affiliation_string":"The Univ. of British Columbia Okanagan (Canada)","institution_ids":["https://openalex.org/I822440","https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040772609","display_name":"Fran\u00e7ois B\u00e9nard","orcid":"https://orcid.org/0000-0001-7995-3581"},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Francois Benard","raw_affiliation_strings":["British Columbia Cancer Agency (Canada)"],"affiliations":[{"raw_affiliation_string":"British Columbia Cancer Agency (Canada)","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048546438","display_name":"A. \u0106eller","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anna Celler","raw_affiliation_strings":["The Univ. of British Columbia (Canada)"],"affiliations":[{"raw_affiliation_string":"The Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108525396","display_name":"Thomas J. Ruth","orcid":null},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas J. Ruth","raw_affiliation_strings":["British Columbia Cancer Agency (Canada)","TRIUMF (Canada)"],"affiliations":[{"raw_affiliation_string":"British Columbia Cancer Agency (Canada)","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"TRIUMF (Canada)","institution_ids":["https://openalex.org/I1304378839"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040691647","display_name":"Paul Schaffer","orcid":"https://orcid.org/0000-0002-6392-8792"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paul Schaffer","raw_affiliation_strings":["TRIUMF (Canada)","The Univ. of British Columbia (Canada)"],"affiliations":[{"raw_affiliation_string":"TRIUMF (Canada)","institution_ids":["https://openalex.org/I1304378839"]},{"raw_affiliation_string":"The Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034984232"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I822440"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0511584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"42","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9868999719619751,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.6518341898918152},{"id":"https://openalex.org/keywords/presentation","display_name":"Presentation (obstetrics)","score":0.6391854882240295},{"id":"https://openalex.org/keywords/alpha","display_name":"Alpha (finance)","score":0.5149224996566772},{"id":"https://openalex.org/keywords/alpha-particle","display_name":"Alpha particle","score":0.5101519227027893},{"id":"https://openalex.org/keywords/resolution","display_name":"Resolution (logic)","score":0.4769503176212311},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4509524703025818},{"id":"https://openalex.org/keywords/computer-graphics","display_name":"Computer graphics (images)","score":0.350541889667511},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2457888424396515},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.1984556019306183},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17165851593017578},{"id":"https://openalex.org/keywords/nuclear-physics","display_name":"Nuclear physics","score":0.13690096139907837},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12518805265426636},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.09927260875701904}],"concepts":[{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.6518341898918152},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.6391854882240295},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5149224996566772},{"id":"https://openalex.org/C66385817","wikidata":"https://www.wikidata.org/wiki/Q103517","display_name":"Alpha particle","level":2,"score":0.5101519227027893},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.4769503176212311},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4509524703025818},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.350541889667511},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2457888424396515},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.1984556019306183},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17165851593017578},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.13690096139907837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12518805265426636},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09927260875701904},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2252282","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2252282","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.49000000953674316,"display_name":"Affordable and clean energy"},{"id":"https://metadata.un.org/sdg/3","score":0.4699999988079071,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2362774332","https://openalex.org/W4249245269","https://openalex.org/W2025681766","https://openalex.org/W2765548132","https://openalex.org/W2159897444","https://openalex.org/W2258788639","https://openalex.org/W2542402767","https://openalex.org/W3023086044","https://openalex.org/W2142226356","https://openalex.org/W3210000161"],"abstract_inverted_index":{"Attaching":[0],"alpha-emitting":[1],"radionuclides":[2],"to":[3,32,43,55,193,207],"cancer-targeting":[4],"agents":[5],"increases":[6],"the":[7,61,119,135,165,172,178,226,243,260],"anti-tumor":[8],"effects":[9],"of":[10,16,37,51,64,69,72,118,124,134,168,195,229,245,251,266],"targeted":[11,28,44],"cancer":[12,52,254],"therapies.":[13],"The":[14],"success":[15],"alpha":[17,29,110,169,174,246],"therapy":[18,30],"for":[19,107],"treating":[20],"bone":[21],"metastases":[22,76],"has":[23,104],"increased":[24],"interest":[25,106],"in":[26,60,74,92,132,148,186,219,248],"using":[27,89,156,197],"(TAT)":[31],"treat":[33],"a":[34,90,99,115,157,223,252],"broad":[35],"spectrum":[36],"metastatic":[38],"cancers.":[39],"Estimating":[40],"radiation":[41],"doses":[42],"tumors,":[45],"including":[46],"small":[47,75],"(<250":[48],"μm)":[49],"clusters":[50],"cells,":[53],"and":[54,98,140,263],"non-targeted":[56],"tissues":[57],"is":[58,77],"critical":[59],"pre-clinical":[62,82,108],"development":[63],"TATs.":[65],"However,":[66],"accurate":[67],"quantification":[68],"heterogeneous":[70],"distributions":[71],"alpha-emitters":[73],"not":[78],"possible":[79],"with":[80,94,201,222],"existing":[81],"in-vivo":[83],"imaging":[84,194],"systems.":[85,127,269],"Ex-vivo":[86],"digital":[87,125,238,267],"autoradiography":[88,126,239,268],"scintillator":[91,200],"combination":[93],"an":[95,198],"image":[96,261],"intensifier":[97],"charged":[100],"coupled":[101],"device":[102],"(CCD)":[103],"gained":[105],"ex-vivo":[109],"particle":[111],"imaging.":[112],"We":[113,144,189],"present":[114],"simulation-based":[116],"analysis":[117,192,211],"fundamental":[120],"spatial":[121],"resolution":[122,129],"limits":[123],"Spatial":[128],"was":[130],"quantified":[131],"terms":[133],"modulation":[136],"transfer":[137],"function":[138],"(MTF)":[139],"Wagner's":[141],"equivalent":[142],"aperture.":[143],"modeled":[145],"systems":[146,159,216],"operating":[147],"either":[149],"particle-counting":[150,220],"(PC)":[151],"or":[152],"energy-integrating":[153],"(EI)":[154],"mode":[155,221],"cascaded":[158],"approach":[160],"that":[161,213,237],"accounts":[162],"for:":[163],"1)":[164],"stopping":[166],"power":[167],"particles;":[170],"2)":[171],"distance":[173],"particles":[175],"travel":[176],"within":[177],"scintillator;":[179],"3)":[180],"optical":[181],"blur,":[182],"and;":[183],"4)":[184],"binning":[185],"detector":[187],"elements.":[188],"applied":[190],"our":[191],"astatine-211":[196],"LYSO":[199],"thickness":[202],"ranging":[203],"from":[204],"10":[205],"μm":[206,231],"20":[208],"μm.":[209],"Our":[210],"demonstrates":[212],"when":[214],"these":[215],"are":[217],"operated":[218],"centroid-calculation":[224],"algorithm,":[225],"effective":[227],"apertures":[228],"~35":[230],"can":[232],"be":[233],"achieved,":[234],"which":[235],"suggests":[236],"may":[240],"enable":[241],"quantifying":[242],"uptake":[244],"emitters":[247],"tumors":[249],"consisting":[250],"few":[253],"cells.":[255],"Future":[256],"work":[257],"will":[258],"investigate":[259],"noise":[262],"energy-resolution":[264],"properties":[265]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}