{"id":"https://openalex.org/W2303043349","doi":"https://doi.org/10.1117/12.2217313","title":"Landmark based shape analysis for cerebellar ataxia classification and cerebellar atrophy pattern visualization","display_name":"Landmark based shape analysis for cerebellar ataxia classification and cerebellar atrophy pattern visualization","publication_year":2016,"publication_date":"2016-03-21","ids":{"openalex":"https://openalex.org/W2303043349","doi":"https://doi.org/10.1117/12.2217313","mag":"2303043349","pmid":"https://pubmed.ncbi.nlm.nih.gov/27303111"},"language":"en","primary_location":{"id":"doi:10.1117/12.2217313","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2217313","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060525920","display_name":"Zhen Yang","orcid":"https://orcid.org/0000-0001-9289-4600"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhen Yang","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063988947","display_name":"S. Mazdak Abulnaga","orcid":"https://orcid.org/0000-0001-7902-3640"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S. Mazdak Abulnaga","raw_affiliation_strings":["The Univ. of British Columbia (Canada)"],"affiliations":[{"raw_affiliation_string":"The Univ. of British Columbia (Canada)","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075622613","display_name":"Aaron Carass","orcid":"https://orcid.org/0000-0003-4939-5085"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Carass","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945686","display_name":"Kalyani Kansal","orcid":null},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalyani Kansal","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036011059","display_name":"Bruno Jedynak","orcid":"https://orcid.org/0000-0002-0824-5745"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruno M. Jedynak","raw_affiliation_strings":["Johns Hopkins Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046803794","display_name":"Chiadi U. Onyike","orcid":"https://orcid.org/0000-0003-2255-4437"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiadi Onyike","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113605332","display_name":"Sarah H. Ying","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah H. Ying","raw_affiliation_strings":["Johns Hopkins Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066682675","display_name":"Jerry L. Prince","orcid":"https://orcid.org/0000-0002-6553-0876"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry L. Prince","raw_affiliation_strings":["Johns Hopkins Univ. (United States)","Johns Hopkins Univ. School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. (United States)","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Univ. School of Medicine (United States)","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5060525920"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.5707,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70304349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9784","issue":null,"first_page":"97840P","last_page":"97840P"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9855999946594238,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9825000166893005,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebellar-ataxia","display_name":"Cerebellar ataxia","score":0.6771465539932251},{"id":"https://openalex.org/keywords/linear-discriminant-analysis","display_name":"Linear discriminant analysis","score":0.6511516571044922},{"id":"https://openalex.org/keywords/spinocerebellar-ataxia","display_name":"Spinocerebellar ataxia","score":0.6305404901504517},{"id":"https://openalex.org/keywords/cerebellum","display_name":"Cerebellum","score":0.6224138140678406},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5246908068656921},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5140615701675415},{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.4786592423915863},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4523495137691498},{"id":"https://openalex.org/keywords/landmark","display_name":"Landmark","score":0.4168175160884857},{"id":"https://openalex.org/keywords/ataxia","display_name":"Ataxia","score":0.38898470997810364},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.30363017320632935},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.29471462965011597},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.19779422879219055},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18870431184768677}],"concepts":[{"id":"https://openalex.org/C2780148635","wikidata":"https://www.wikidata.org/wiki/Q154709","display_name":"Cerebellar ataxia","level":3,"score":0.6771465539932251},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.6511516571044922},{"id":"https://openalex.org/C2779500118","wikidata":"https://www.wikidata.org/wiki/Q899726","display_name":"Spinocerebellar ataxia","level":3,"score":0.6305404901504517},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.6224138140678406},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5246908068656921},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5140615701675415},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4786592423915863},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4523495137691498},{"id":"https://openalex.org/C2780297707","wikidata":"https://www.wikidata.org/wiki/Q4895393","display_name":"Landmark","level":2,"score":0.4168175160884857},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.38898470997810364},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30363017320632935},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29471462965011597},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19779422879219055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18870431184768677}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1117/12.2217313","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2217313","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:27303111","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27303111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:3869679","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4903164","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pdxscholar.library.pdx.edu:mth_fac-1449","is_oa":false,"landing_page_url":"https://pdxscholar.library.pdx.edu/mth_fac/444","pdf_url":null,"source":{"id":"https://openalex.org/S4377196300","display_name":"PDXScholar  (Portland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I126345244","host_organization_name":"Portland State University","host_organization_lineage":["https://openalex.org/I126345244"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mathematics and Statistics Faculty Publications and Presentations","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7099999785423279,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W25966859","https://openalex.org/W113626522","https://openalex.org/W188692684","https://openalex.org/W1517542533","https://openalex.org/W1548943871","https://openalex.org/W1971223222","https://openalex.org/W1984323662","https://openalex.org/W1986659412","https://openalex.org/W2001619934","https://openalex.org/W2037924174","https://openalex.org/W2038952578","https://openalex.org/W2064237880","https://openalex.org/W2066861429","https://openalex.org/W2079878788","https://openalex.org/W2081287867","https://openalex.org/W2116460180","https://openalex.org/W2119800915","https://openalex.org/W2119848633","https://openalex.org/W2123225824","https://openalex.org/W2134236847","https://openalex.org/W2142445683","https://openalex.org/W2146417264","https://openalex.org/W2153171432","https://openalex.org/W2153798798","https://openalex.org/W2153862949","https://openalex.org/W2155423555","https://openalex.org/W2159167610","https://openalex.org/W2229412420","https://openalex.org/W4296590569","https://openalex.org/W4298223777","https://openalex.org/W6601078197","https://openalex.org/W6607704586","https://openalex.org/W6632931725","https://openalex.org/W6643139476","https://openalex.org/W6677912132"],"related_works":["https://openalex.org/W2019983375","https://openalex.org/W2167376420","https://openalex.org/W2088525571","https://openalex.org/W2402174938","https://openalex.org/W4293738682","https://openalex.org/W4226044296","https://openalex.org/W4383371739","https://openalex.org/W2033545352","https://openalex.org/W1963889847","https://openalex.org/W2977889816"],"abstract_inverted_index":{"Cerebellar":[0],"dysfunction":[1],"can":[2,22,136],"lead":[3],"to":[4,42,51],"a":[5,36],"wide":[6],"range":[7],"of":[8,67,82,172,177,184],"movement":[9],"disorders.":[10],"Studying":[11],"the":[12,53,68,79,119,126,133,153,162,178],"cerebellar":[13,19,55,69,83,147],"atrophy":[14,56,108,148],"pattern":[15,109],"associated":[16,58],"with":[17,59,152],"different":[18,47,60,142],"disease":[20],"types":[21,49],"potentially":[23],"help":[24],"in":[25,158],"diagnosis,":[26],"prognosis,":[27],"and":[28,46,50,101,125,141,167,175],"treatment":[29],"planning.":[30],"In":[31],"this":[32,91],"paper,":[33],"we":[34],"present":[35],"landmark":[37],"based":[38,89],"shape":[39,176],"analysis":[40],"pipeline":[41],"classify":[43,138],"healthy":[44,123,139],"control":[45],"ataxia":[48,112,127,143],"visualize":[52],"characteristic":[54,107],"patterns":[57,149],"types.":[61,144],"A":[62,85],"highly":[63],"informative":[64],"feature":[65],"representation":[66,92],"structure":[70],"is":[71,93,114],"constructed":[72],"by":[73,116],"extracting":[74],"dense":[75],"homologous":[76],"landmarks":[77],"on":[78,90],"boundary":[80],"surfaces":[81],"sub-structures.":[84],"diagnosis":[86],"group":[87],"classifier":[88],"built":[94],"using":[95],"partial":[96],"least":[97],"square":[98],"dimension":[99],"reduction":[100],"regularized":[102],"linear":[103],"discriminant":[104,120],"analysis.":[105],"The":[106,145],"for":[110],"an":[111],"type":[113],"visualized":[115,146],"sampling":[117],"along":[118],"direction":[121],"between":[122],"controls":[124,140],"type.":[128],"Experimental":[129],"results":[130],"show":[131],"that":[132,183],"proposed":[134,163],"method":[135,164],"successfully":[137],"were":[150],"consistent":[151],"regional":[154],"volume":[155],"decreases":[156],"observed":[157],"previous":[159],"studies,":[160],"but":[161],"provides":[165],"intuitive":[166],"detailed":[168],"understanding":[169],"about":[170],"changes":[171],"overall":[173],"size":[174],"cerebellum,":[179],"as":[180,182],"well":[181],"individual":[185],"lobules.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}