{"id":"https://openalex.org/W2313146511","doi":"https://doi.org/10.1117/12.2216912","title":"Axonal diameter and density estimated with 7-Tesla hybrid diffusion imaging in transgenic Alzheimer rats","display_name":"Axonal diameter and density estimated with 7-Tesla hybrid diffusion imaging in transgenic Alzheimer rats","publication_year":2016,"publication_date":"2016-03-21","ids":{"openalex":"https://openalex.org/W2313146511","doi":"https://doi.org/10.1117/12.2216912","mag":"2313146511"},"language":"en","primary_location":{"id":"doi:10.1117/12.2216912","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.2216912","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/9784/97843G/Axonal-diameter-and-density-estimated-with-7-Tesla-hybrid-diffusion/10.1117/12.2216912.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/9784/97843G/Axonal-diameter-and-density-estimated-with-7-Tesla-hybrid-diffusion/10.1117/12.2216912.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069073490","display_name":"Madelaine Daianu","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Madelaine Daianu","raw_affiliation_strings":["The Univ. of Southern California (United States)","UCLA School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"UCLA School of Medicine (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027132236","display_name":"Russell E. Jacobs","orcid":"https://orcid.org/0000-0002-1382-8486"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell E. Jacobs","raw_affiliation_strings":["California Institute of Technology (United States)"],"affiliations":[{"raw_affiliation_string":"California Institute of Technology (United States)","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016366290","display_name":"Terrence Town","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrence Town","raw_affiliation_strings":["The Univ. of Southern California (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["The Univ. of Southern California (United States)","UCLA School of Medicine (United States)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"UCLA School of Medicine (United States)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069073490"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":1.1413,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.78295321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9784","issue":null,"first_page":"97843G","last_page":"97843G"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/splenium","display_name":"Splenium","score":0.7216067910194397},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"Corpus callosum","score":0.718471109867096},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.6970908045768738},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5540847778320312},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.5409120321273804},{"id":"https://openalex.org/keywords/axon","display_name":"Axon","score":0.5402535796165466},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"Fractional anisotropy","score":0.4272800385951996},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.40838828682899475},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.38352811336517334},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.36530232429504395},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.32797133922576904},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3193643093109131},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31005364656448364},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2702569365501404},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.11567550897598267}],"concepts":[{"id":"https://openalex.org/C2776643646","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Splenium","level":4,"score":0.7216067910194397},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.718471109867096},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6970908045768738},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5540847778320312},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.5409120321273804},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5402535796165466},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.4272800385951996},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.40838828682899475},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38352811336517334},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36530232429504395},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32797133922576904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3193643093109131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31005364656448364},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2702569365501404},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.11567550897598267}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2216912","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.2216912","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/9784/97843G/Axonal-diameter-and-density-estimated-with-7-Tesla-hybrid-diffusion/10.1117/12.2216912.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:authors.library.caltech.edu:72540","is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/72540/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":{"id":"doi:10.1117/12.2216912","is_oa":true,"landing_page_url":"https://doi.org/10.1117/12.2216912","pdf_url":"https://www.spiedigitallibrary.org/conference-proceedings-of-spie/9784/97843G/Axonal-diameter-and-density-estimated-with-7-Tesla-hybrid-diffusion/10.1117/12.2216912.pdf","source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1083261582","display_name":null,"funder_award_id":"AG040060","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1175005316","display_name":null,"funder_award_id":"MH097268","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1292971008","display_name":null,"funder_award_id":"R01 EB008281","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2533166933","display_name":null,"funder_award_id":"EB000993","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G2765534709","display_name":null,"funder_award_id":"R01 EB008432","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3037558670","display_name":null,"funder_award_id":"EB01651","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3354284890","display_name":null,"funder_award_id":"NIBIB","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3495954047","display_name":null,"funder_award_id":"EB008432","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G3503195557","display_name":null,"funder_award_id":"EB020403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3510044943","display_name":null,"funder_award_id":"MH097268","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4700852728","display_name":null,"funder_award_id":"R01 NS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4741411087","display_name":null,"funder_award_id":"EB008281","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G4879441828","display_name":null,"funder_award_id":"R01 EB008281","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5151740994","display_name":null,"funder_award_id":"U54 EB020403","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5232990539","display_name":null,"funder_award_id":"AG016570","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5544719773","display_name":null,"funder_award_id":"EB008281","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5944399113","display_name":null,"funder_award_id":"EB000993","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6101378320","display_name":null,"funder_award_id":"R01 NS076794","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6151475199","display_name":null,"funder_award_id":"020403","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6372774422","display_name":null,"funder_award_id":"R01 EB008432","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6423720423","display_name":null,"funder_award_id":"EB008281","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6510794463","display_name":null,"funder_award_id":"EB008432","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6908884664","display_name":null,"funder_award_id":"LM05639","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6915252823","display_name":null,"funder_award_id":"16570","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7282846938","display_name":null,"funder_award_id":"R01NS076794","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7326523540","display_name":null,"funder_award_id":"U54 EB020403","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7586206247","display_name":null,"funder_award_id":"R01 AG034499","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7772390146","display_name":null,"funder_award_id":"R01 EB008281","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G910922941","display_name":null,"funder_award_id":"U54 EB020403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309398","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333811","display_name":"Beckman Institute, California Institute of Technology","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2313146511.pdf","grobid_xml":"https://content.openalex.org/works/W2313146511.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W212537071","https://openalex.org/W848635999","https://openalex.org/W1743269311","https://openalex.org/W1919284595","https://openalex.org/W1964802316","https://openalex.org/W1975017507","https://openalex.org/W1975735271","https://openalex.org/W1983183710","https://openalex.org/W2022630760","https://openalex.org/W2060019728","https://openalex.org/W2060554185","https://openalex.org/W2127635814","https://openalex.org/W2160112896","https://openalex.org/W2166578434","https://openalex.org/W2167625655","https://openalex.org/W2175040943","https://openalex.org/W2201113688","https://openalex.org/W2219480017","https://openalex.org/W4233516019","https://openalex.org/W4236469787","https://openalex.org/W6640072918","https://openalex.org/W6646041480","https://openalex.org/W6665757909","https://openalex.org/W6684430096"],"related_works":["https://openalex.org/W2093335954","https://openalex.org/W2372420629","https://openalex.org/W4255412133","https://openalex.org/W2410261297","https://openalex.org/W2024192868","https://openalex.org/W2084577173","https://openalex.org/W2167408532","https://openalex.org/W2387524778","https://openalex.org/W2049444094","https://openalex.org/W1977877868"],"abstract_inverted_index":{"Diffusion-weighted":[0],"MR":[1,142,193],"imaging":[2,47],"(DWI)":[3],"is":[4,14],"a":[5],"powerful":[6],"tool":[7],"to":[8,16,49,229],"study":[9],"brain":[10,30,239],"tissue":[11],"microstructure.":[12],"DWI":[13,77],"sensitive":[15],"subtle":[17],"changes":[18,31],"in":[19,32,112,123,137,150,192,196,205,213],"the":[20,58,63,90,113,138,153,176,214,236],"white":[21],"matter":[22],"(WM),":[23],"and":[24,71,110,140,156,170,200,232],"can":[25],"provide":[26,230],"insight":[27,234],"into":[28,235],"abnormal":[29],"diseases":[33],"such":[34],"as":[35,172],"Alzheimer\u2019s":[36],"disease":[37],"(AD).":[38],"In":[39],"this":[40],"study,":[41],"we":[42,99],"used":[43],"7-Tesla":[44],"hybrid":[45],"diffusion":[46],"(HYDI)":[48],"scan":[50],"3":[51],"transgenic":[52],"rats":[53],"(line":[54],"TgF344-AD;":[55],"that":[56,121],"model":[57],"full":[59],"clinico-pathological":[60],"spectrum":[61],"of":[62,102,107,152,221,238],"human":[64],"disease)":[65],"ex":[66],"vivo":[67],"at":[68,175,216],"10,":[69],"15":[70],"24":[72,219],"months.":[73],"We":[74],"acquired":[75],"300":[76],"volumes":[78],"across":[79],"5":[80],"q-sampling":[81],"shells":[82,94],"(b=1000,":[83],"3000,":[84],"4000,":[85],"8000,":[86],"12000":[87],"s/mm<sup>2</sup>).":[88],"From":[89],"top":[91],"three":[92],"b-value":[93],"with":[95,131],"highest":[96],"signal-to-noise":[97],"ratios,":[98],"reconstructed":[100],"markers":[101],"WM":[103,206],"disease,":[104],"including":[105],"indices":[106],"axon":[108],"density":[109],"diameter":[111],"corpus":[114],"callosum":[115],"(CC)":[116],"\u2013":[117,165],"directly":[118],"quantifying":[119],"processes":[120],"occur":[122],"AD.":[124],"As":[125],"expected,":[126],"apparent":[127],"anisotropy":[128],"progressively":[129],"decreased":[130],"age;":[132],"there":[133],"were":[134,148],"also":[135],"decreases":[136],"intra-":[139],"extra-axonal":[141],"signal":[143],"along":[144],"axons.":[145],"Axonal":[146],"diameters":[147],"larger":[149],"segments":[151],"CC":[154,215],"(splenium":[155],"body,":[157],"but":[158],"not":[159],"genu),":[160],"possibly":[161,201],"indicating":[162],"neuritic":[163],"dystrophy":[164],"characterized":[166],"by":[167,190],"enlarged":[168],"axons":[169],"dendrites":[171],"previously":[173],"observed":[174],"ultrastructural":[177],"level":[178],"(see":[179],"Cohen":[180],"et":[181],"al.,":[182],"J.":[183],"Neurosci.":[184],"2013).":[185],"This":[186],"was":[187],"further":[188],"supported":[189],"increases":[191],"signals":[194],"trapped":[195],"glial":[197],"cells,":[198],"CSF":[199],"other":[202],"small":[203],"compartments":[204],"structures.":[207],"Finally,":[208],"tractography":[209],"detected":[210],"fewer":[211],"fibers":[212],"10":[217],"versus":[218],"months":[220],"age.":[222],"These":[223],"novel":[224],"findings":[225],"offer":[226],"great":[227],"potential":[228],"technical":[231],"scientific":[233],"biology":[237],"disease.":[240]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}