{"id":"https://openalex.org/W2332117008","doi":"https://doi.org/10.1117/12.2216703","title":"An SPM12 extension for multiple sclerosis lesion segmentation","display_name":"An SPM12 extension for multiple sclerosis lesion segmentation","publication_year":2016,"publication_date":"2016-03-21","ids":{"openalex":"https://openalex.org/W2332117008","doi":"https://doi.org/10.1117/12.2216703","mag":"2332117008"},"language":"en","primary_location":{"id":"doi:10.1117/12.2216703","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2216703","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081276735","display_name":"Eloy Roura","orcid":"https://orcid.org/0000-0003-0325-9563"},"institutions":[{"id":"https://openalex.org/I251424209","display_name":"University of Girona","ror":"https://ror.org/01xdxns91","country_code":"ES","type":"education","lineage":["https://openalex.org/I251424209"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Eloy Roura","raw_affiliation_strings":["Univ. de Girona (Spain)"],"affiliations":[{"raw_affiliation_string":"Univ. de Girona (Spain)","institution_ids":["https://openalex.org/I251424209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027168396","display_name":"Arnau Oliver","orcid":"https://orcid.org/0000-0002-0115-0647"},"institutions":[{"id":"https://openalex.org/I251424209","display_name":"University of Girona","ror":"https://ror.org/01xdxns91","country_code":"ES","type":"education","lineage":["https://openalex.org/I251424209"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Arnau Oliver","raw_affiliation_strings":["Univ. de Girona (Spain)"],"affiliations":[{"raw_affiliation_string":"Univ. de Girona (Spain)","institution_ids":["https://openalex.org/I251424209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049566648","display_name":"Mariano Cabezas","orcid":"https://orcid.org/0000-0002-4417-1704"},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127641"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mariano Cabezas","raw_affiliation_strings":["Hospital Univ. Vall d\u2019Hebron (Spain)","Hospital Univ. Vall d'Hebron (Spain)"],"affiliations":[{"raw_affiliation_string":"Hospital Univ. Vall d\u2019Hebron (Spain)","institution_ids":["https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Hospital Univ. Vall d'Hebron (Spain)","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085592048","display_name":"Sergi Valverde","orcid":"https://orcid.org/0000-0002-0963-0936"},"institutions":[{"id":"https://openalex.org/I251424209","display_name":"University of Girona","ror":"https://ror.org/01xdxns91","country_code":"ES","type":"education","lineage":["https://openalex.org/I251424209"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergi Valverde","raw_affiliation_strings":["Univ. de Girona (Spain)"],"affiliations":[{"raw_affiliation_string":"Univ. de Girona (Spain)","institution_ids":["https://openalex.org/I251424209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027999733","display_name":"Deborah Pareto","orcid":"https://orcid.org/0000-0001-7356-3769"},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127641"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Deborah Pareto","raw_affiliation_strings":["Hospital Univ. Vall d\u2019Hebron (Spain)","Hospital Univ. Vall d'Hebron (Spain)"],"affiliations":[{"raw_affiliation_string":"Hospital Univ. Vall d\u2019Hebron (Spain)","institution_ids":["https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Hospital Univ. Vall d'Hebron (Spain)","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066247010","display_name":"Joan C. Vilanova","orcid":"https://orcid.org/0000-0003-2148-6751"},"institutions":[{"id":"https://openalex.org/I4210092868","display_name":"Cl\u00ednica Girona","ror":"https://ror.org/00hxspe04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210092868"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joan C. Vilanova","raw_affiliation_strings":["Girona Magnetic Resonance Ctr. (Spain)"],"affiliations":[{"raw_affiliation_string":"Girona Magnetic Resonance Ctr. (Spain)","institution_ids":["https://openalex.org/I4210092868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082890627","display_name":"Llu\u00eds Rami\u00f3\u2010Torrent\u00e0","orcid":"https://orcid.org/0000-0002-6999-1004"},"institutions":[{"id":"https://openalex.org/I4210154933","display_name":"Hospital Universitari de Girona Doctor Josep Trueta","ror":"https://ror.org/04g27v387","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210154933"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Llu\u00eds Rami\u00f3-Torrent\u00e0","raw_affiliation_strings":["Dr. Josep Trueta Univ. Hospital (Spain)"],"affiliations":[{"raw_affiliation_string":"Dr. Josep Trueta Univ. Hospital (Spain)","institution_ids":["https://openalex.org/I4210154933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063275381","display_name":"\u00c0lex Rovira","orcid":"https://orcid.org/0000-0002-2132-6750"},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127641"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c0lex Rovira","raw_affiliation_strings":["Hospital Univ. Vall d\u2019Hebron (Spain)","Hospital Univ. Vall d'Hebron (Spain)"],"affiliations":[{"raw_affiliation_string":"Hospital Univ. Vall d\u2019Hebron (Spain)","institution_ids":["https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Hospital Univ. Vall d'Hebron (Spain)","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064897887","display_name":"Xavier Llad\u00f3","orcid":"https://orcid.org/0000-0003-2777-3479"},"institutions":[{"id":"https://openalex.org/I251424209","display_name":"University of Girona","ror":"https://ror.org/01xdxns91","country_code":"ES","type":"education","lineage":["https://openalex.org/I251424209"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xavier Llad\u00f3","raw_affiliation_strings":["Univ. de Girona (Spain)"],"affiliations":[{"raw_affiliation_string":"Univ. de Girona (Spain)","institution_ids":["https://openalex.org/I251424209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5081276735"],"corresponding_institution_ids":["https://openalex.org/I251424209"],"apc_list":null,"apc_paid":null,"fwci":0.2399,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58584429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9784","issue":null,"first_page":"97842N","last_page":"97842N"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9864000082015991,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7528872489929199},{"id":"https://openalex.org/keywords/fluid-attenuated-inversion-recovery","display_name":"Fluid-attenuated inversion recovery","score":0.7441017627716064},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6855145692825317},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5724753737449646},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.5049248337745667},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.47329750657081604},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4699065089225769},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.4663117825984955},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.42577242851257324},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.41007161140441895},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.2960314154624939},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1551489531993866},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.133556067943573}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7528872489929199},{"id":"https://openalex.org/C101070640","wikidata":"https://www.wikidata.org/wiki/Q3737215","display_name":"Fluid-attenuated inversion recovery","level":3,"score":0.7441017627716064},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6855145692825317},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5724753737449646},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.5049248337745667},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.47329750657081604},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4699065089225769},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4663117825984955},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.42577242851257324},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.41007161140441895},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2960314154624939},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1551489531993866},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.133556067943573},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2216703","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2216703","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310701","display_name":"Fundaci\u00f3 la Marat\u00f3 de TV3","ror":"https://ror.org/00t5xc355"},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W138041180","https://openalex.org/W341325887","https://openalex.org/W989828740","https://openalex.org/W1973457617","https://openalex.org/W2000308637","https://openalex.org/W2023933689","https://openalex.org/W2091274498","https://openalex.org/W2102848905","https://openalex.org/W2122545833","https://openalex.org/W2150134853","https://openalex.org/W2157848968","https://openalex.org/W2495046128","https://openalex.org/W4230920194","https://openalex.org/W6605645309"],"related_works":["https://openalex.org/W2397888002","https://openalex.org/W2356247871","https://openalex.org/W2373716292","https://openalex.org/W2381429000","https://openalex.org/W2364564193","https://openalex.org/W2393352769","https://openalex.org/W2131742827","https://openalex.org/W4389341328","https://openalex.org/W4309923383","https://openalex.org/W2408873457"],"abstract_inverted_index":{"Purpose:":[0],"Magnetic":[1],"resonance":[2],"imaging":[3],"is":[4,68,116],"nowadays":[5],"the":[6,26,42,62,124,132,144,173,207,215,234,238,243],"hallmark":[7],"to":[8,24,55,92,122,137,149,164],"diagnose":[9],"multiple":[10],"sclerosis":[11],"(MS),":[12],"characterized":[13],"by":[14],"white":[15,58],"matter":[16,59],"lesions.":[17],"Several":[18],"approaches":[19,190],"have":[20,34,99,130,200,228],"been":[21,35,162,176],"recently":[22],"presented":[23],"tackle":[25],"lesion":[27,194],"segmentation":[28,126],"problem,":[29],"but":[30],"none":[31],"of":[32,71,119,172,193,206,237],"them":[33],"accepted":[36],"as":[37],"a":[38,109,153,210],"standard":[39],"tool":[40,53,174],"in":[41,143,191],"daily":[43],"clinical":[44],"practice.":[45],"In":[46],"this":[47,231],"work":[48,67],"we":[49,98,129],"present":[50],"yet":[51],"another":[52],"able":[54],"automatically":[56],"segment":[57],"lesions":[60],"outperforming":[61],"current-state-of-the-art":[63],"approaches.":[64],"Methods:":[65],"This":[66],"an":[69,94],"extension":[70],"Roura":[72],"et":[73],"al.":[74],"[1],":[75],"where":[76],"external":[77,120],"and":[78,87,101,159,183,196,204,224],"platform":[79],"dependent":[80],"pre-processing":[81,106],"libraries":[82],"(brain":[83],"extraction,":[84],"noise":[85],"reduction":[86],"intensity":[88],"normalization)":[89],"were":[90],"required":[91,105],"achieve":[93,123],"optimal":[95],"performance.":[96,244],"Here":[97],"updated":[100],"included":[102],"all":[103],"these":[104],"steps":[107],"into":[108,214],"single":[110],"framework":[111],"(SPM":[112],"software).":[113],"Therefore,":[114],"there":[115],"no":[117],"need":[118],"tools":[121],"desired":[125],"results.":[127],"Besides,":[128],"changed":[131],"working":[133],"space":[134],"from":[135,147],"T1w":[136,150,223],"FLAIR,":[138],"reducing":[139],"interpolation":[140],"errors":[141],"produced":[142],"registration":[145],"process":[146],"FLAIR":[148,225],"space.":[151],"Finally":[152],"post-processing":[154],"constraint":[155],"based":[156],"on":[157,178,221],"shape":[158],"location":[160],"has":[161,175],"added":[163],"reduce":[165],"false":[166],"positive":[167],"detections.":[168],"Results:":[169],"The":[170],"evaluation":[171],"done":[177],"24":[179],"MS":[180],"patients.":[181],"Qualitative":[182],"quantitative":[184],"results":[185],"are":[186],"shown":[187],"with":[188,230],"both":[189,202],"terms":[192],"detection":[195],"segmentation.":[197],"Conclusion:":[198],"We":[199,227],"simplified":[201],"installation":[203],"implementation":[205],"approach,":[208],"providing":[209],"multiplatform":[211],"tool1":[212],"integrated":[213],"SPM":[216],"software,":[217],"which":[218],"relies":[219],"only":[220],"using":[222],"images.":[226],"reduced":[229],"new":[232],"version":[233],"computation":[235],"time":[236],"previous":[239],"approach":[240],"while":[241],"maintaining":[242]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}