{"id":"https://openalex.org/W2332581158","doi":"https://doi.org/10.1117/12.2216175","title":"Effect of low-dose CT and iterative reconstruction on trabecular bone microstructure assessment","display_name":"Effect of low-dose CT and iterative reconstruction on trabecular bone microstructure assessment","publication_year":2016,"publication_date":"2016-03-29","ids":{"openalex":"https://openalex.org/W2332581158","doi":"https://doi.org/10.1117/12.2216175","mag":"2332581158"},"language":"en","primary_location":{"id":"doi:10.1117/12.2216175","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2216175","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008508081","display_name":"Felix K. Kopp","orcid":"https://orcid.org/0000-0003-2069-4444"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Felix K. Kopp","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070725191","display_name":"Thomas Baum","orcid":"https://orcid.org/0000-0002-4574-5212"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Baum","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028315825","display_name":"Radin A. Nasirudin","orcid":"https://orcid.org/0000-0003-0279-1558"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radin A. Nasirudin","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025712718","display_name":"Kai Mei","orcid":"https://orcid.org/0000-0002-6429-7830"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Mei","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056356973","display_name":"Eduardo Grande Garc\u00eda","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo G. Garcia","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072566909","display_name":"Rainer Burgkart","orcid":"https://orcid.org/0000-0002-9107-4229"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rainer Burgkart","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083768671","display_name":"Ernst J. Rummeny","orcid":"https://orcid.org/0000-0002-1935-5886"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernst J. Rummeny","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109182967","display_name":"Jan S. Bauer","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan S. Bauer","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050134612","display_name":"Peter B. No\u00ebl","orcid":"https://orcid.org/0000-0002-9671-6171"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter B. No\u00ebl","raw_affiliation_strings":["Technische Univ. M\u00fcnchen (Germany)"],"affiliations":[{"raw_affiliation_string":"Technische Univ. M\u00fcnchen (Germany)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5008508081"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.55950576,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69149479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9788","issue":null,"first_page":"97881R","last_page":"97881R"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporosis","display_name":"Osteoporosis","score":0.7399960160255432},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"Quantitative computed tomography","score":0.6849772930145264},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.5906816720962524},{"id":"https://openalex.org/keywords/vertebra","display_name":"Vertebra","score":0.5675387382507324},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5295164585113525},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.522666871547699},{"id":"https://openalex.org/keywords/imaging-phantom","display_name":"Imaging phantom","score":0.502037525177002},{"id":"https://openalex.org/keywords/bone-mineral","display_name":"Bone mineral","score":0.4910256862640381},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.47132423520088196},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4612058997154236},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.45551103353500366},{"id":"https://openalex.org/keywords/microstructure","display_name":"Microstructure","score":0.4499087929725647},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.39179039001464844},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3203246593475342},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.09590029716491699}],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7399960160255432},{"id":"https://openalex.org/C2777425516","wikidata":"https://www.wikidata.org/wiki/Q17083560","display_name":"Quantitative computed tomography","level":4,"score":0.6849772930145264},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.5906816720962524},{"id":"https://openalex.org/C2776412215","wikidata":"https://www.wikidata.org/wiki/Q180323","display_name":"Vertebra","level":2,"score":0.5675387382507324},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5295164585113525},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.522666871547699},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.502037525177002},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.4910256862640381},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.47132423520088196},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4612058997154236},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.45551103353500366},{"id":"https://openalex.org/C87976508","wikidata":"https://www.wikidata.org/wiki/Q1498213","display_name":"Microstructure","level":2,"score":0.4499087929725647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39179039001464844},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3203246593475342},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09590029716491699},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2216175","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2216175","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W18886075","https://openalex.org/W1965528481","https://openalex.org/W1982234946","https://openalex.org/W2015116522","https://openalex.org/W2062680483","https://openalex.org/W2117369607","https://openalex.org/W2123676698","https://openalex.org/W2123822872","https://openalex.org/W2145019447","https://openalex.org/W2150358707","https://openalex.org/W2152142562","https://openalex.org/W2153719448","https://openalex.org/W2167403983","https://openalex.org/W2914779954","https://openalex.org/W3202522595","https://openalex.org/W4214500985","https://openalex.org/W6682345030","https://openalex.org/W6759364716"],"related_works":["https://openalex.org/W2007297965","https://openalex.org/W2395988836","https://openalex.org/W2417440389","https://openalex.org/W2092013139","https://openalex.org/W2053289625","https://openalex.org/W2046809491","https://openalex.org/W3164261097","https://openalex.org/W2093936017","https://openalex.org/W2144778520","https://openalex.org/W2463033330"],"abstract_inverted_index":{"The":[0,153],"trabecular":[1,33],"bone":[2,34,60,134],"microstructure":[3,35,135,204],"is":[4,14,20,87],"an":[5],"important":[6],"factor":[7],"in":[8,112,217],"the":[9,30,48,59,84,98,104,160,229],"development":[10],"of":[11,32,40,47,58,89,165],"osteoporosis.":[12],"It":[13],"well":[15,183],"known":[16],"that":[17,29],"its":[18],"deterioration":[19],"one":[21,88],"effect":[22],"when":[23],"osteoporosis":[24,41],"occurs.":[25],"Previous":[26],"research":[27],"showed":[28],"analysis":[31],"enables":[36],"more":[37],"precise":[38],"diagnoses":[39],"compared":[42],"to":[43,83,97,159,199,219],"a":[44],"sole":[45],"measurement":[46],"mineral":[49],"density.":[50],"Microstructure":[51,168],"parameters":[52,136,156,169,185,205],"are":[53,109],"assessed":[54,138,170,186,211],"on":[55],"volumetric":[56],"images":[57,141],"acquired":[61],"either":[62],"with":[63,78,127,143,175,179,191,197,228],"high-resolution":[64,68,74],"magnetic":[65],"resonance":[66],"imaging,":[67],"peripheral":[69],"quantitative":[70],"computed":[71,75],"tomography":[72,76],"or":[73],"(CT),":[77],"only":[79],"CT":[80,140],"being":[81],"applicable":[82,111],"spine,":[85],"which":[86],"clinically":[90],"most":[91],"relevant":[92],"fracture":[93,163,180],"sites.":[94],"However,":[95],"due":[96],"high":[99],"radiation":[100,131],"exposure":[101],"for":[102,139,171,187,212],"imaging":[103],"whole":[105],"spine":[106],"these":[107],"measurements":[108],"not":[110,206],"current":[113],"clinical":[114],"routine.":[115],"In":[116],"this":[117],"work,":[118],"twelve":[119],"vertebrae":[120],"from":[121,209],"three":[122],"different":[123,208],"donors":[124],"were":[125,137,157,195],"scanned":[126],"standard":[128],"and":[129,148],"low":[130,198],"dose.":[132],"Trabecular":[133],"reconstructed":[142,174,190],"statistical":[144],"iterative":[145],"reconstruction":[146],"(SIR)":[147],"analytical":[149],"filtered":[150],"backprojection":[151],"(FBP).":[152],"resulting":[154],"structure":[155],"correlated":[158,178],"biomechanically":[161],"determined":[162],"load":[164],"each":[166],"vertebra.":[167],"low-dose":[172],"data":[173,189],"SIR":[176],"significantly":[177,207],"loads":[181],"as":[182,184],"standard-dose":[188,213],"FBP.":[192],"Ideal":[193],"results":[194],"achieved":[196],"zero":[200],"regularization":[201],"strength":[202],"yielding":[203],"those":[210],"FPB":[214],"data.":[215],"Moreover,":[216],"comparison":[218],"other":[220],"approaches,":[221],"superior":[222],"noise-resolution":[223],"trade-offs":[224],"can":[225],"be":[226],"found":[227],"proposed":[230],"methods.":[231]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}