{"id":"https://openalex.org/W2080696007","doi":"https://doi.org/10.1117/12.2082299","title":"Estimation of tissue optical parameters with hyperspectral imaging and spectral unmixing","display_name":"Estimation of tissue optical parameters with hyperspectral imaging and spectral unmixing","publication_year":2015,"publication_date":"2015-03-17","ids":{"openalex":"https://openalex.org/W2080696007","doi":"https://doi.org/10.1117/12.2082299","mag":"2080696007","pmid":"https://pubmed.ncbi.nlm.nih.gov/26855467"},"language":"en","primary_location":{"id":"doi:10.1117/12.2082299","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082299","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737955","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057729645","display_name":"Guolan Lu","orcid":"https://orcid.org/0000-0002-5023-3465"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guolan Lu","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA","Emory Univ. (United States)","Georgia Institute of Technology (United States)"],"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology (United States)","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021103445","display_name":"Xulei Qin","orcid":"https://orcid.org/0000-0001-9248-4230"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xulei Qin","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450574","display_name":"Dongsheng Wang","orcid":"https://orcid.org/0000-0001-5700-465X"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongsheng Wang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085137065","display_name":"Zhuo G. Chen","orcid":"https://orcid.org/0000-0002-2572-1926"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo G. Chen","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","Emory Univ. (United States)"],"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083707303","display_name":"Baowei Fei","orcid":"https://orcid.org/0000-0002-9123-9484"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baowei Fei","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA; Department of Mathematics & Computer Science, Emory University, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA","Winship Cancer Institute of Emory Univ. (United States)","Emory Univ. (United States)","Georgia Institute of Technology (United States)"],"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA; Department of Mathematics & Computer Science, Emory University, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":[]},{"raw_affiliation_string":"Winship Cancer Institute of Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Univ. (United States)","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Georgia Institute of Technology (United States)","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057729645"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"],"apc_list":null,"apc_paid":null,"fwci":2.0732,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89135242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9417","issue":null,"first_page":"94170Q","last_page":"94170Q"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.9757999777793884,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperspectral-imaging","display_name":"Hyperspectral imaging","score":0.9888284802436829},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6806620359420776},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5551396608352661},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.4905239939689636},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"Cancer detection","score":0.49046704173088074},{"id":"https://openalex.org/keywords/chemical-imaging","display_name":"Chemical imaging","score":0.451369971036911},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.443793922662735},{"id":"https://openalex.org/keywords/spectral-imaging","display_name":"Spectral imaging","score":0.4377990961074829},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.4256364703178406},{"id":"https://openalex.org/keywords/full-spectral-imaging","display_name":"Full spectral imaging","score":0.4233090281486511},{"id":"https://openalex.org/keywords/chromophore","display_name":"Chromophore","score":0.4153089225292206},{"id":"https://openalex.org/keywords/spectral-signature","display_name":"Spectral signature","score":0.4117027521133423},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.40683022141456604},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3984224498271942},{"id":"https://openalex.org/keywords/remote-sensing","display_name":"Remote sensing","score":0.2477979063987732},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.10663896799087524},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10251259803771973},{"id":"https://openalex.org/keywords/geology","display_name":"Geology","score":0.08553615212440491},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07124432921409607}],"concepts":[{"id":"https://openalex.org/C159078339","wikidata":"https://www.wikidata.org/wiki/Q959005","display_name":"Hyperspectral imaging","level":2,"score":0.9888284802436829},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6806620359420776},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5551396608352661},{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.4905239939689636},{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.49046704173088074},{"id":"https://openalex.org/C65597285","wikidata":"https://www.wikidata.org/wiki/Q5090469","display_name":"Chemical imaging","level":3,"score":0.451369971036911},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.443793922662735},{"id":"https://openalex.org/C3232514","wikidata":"https://www.wikidata.org/wiki/Q7575196","display_name":"Spectral imaging","level":2,"score":0.4377990961074829},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.4256364703178406},{"id":"https://openalex.org/C78660771","wikidata":"https://www.wikidata.org/wiki/Q5508206","display_name":"Full spectral imaging","level":3,"score":0.4233090281486511},{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.4153089225292206},{"id":"https://openalex.org/C176641082","wikidata":"https://www.wikidata.org/wiki/Q2446767","display_name":"Spectral signature","level":2,"score":0.4117027521133423},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.40683022141456604},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3984224498271942},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.2477979063987732},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10663896799087524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10251259803771973},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.08553615212440491},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07124432921409607},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2082299","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082299","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:26855467","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26855467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4737955","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737955","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4737955","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737955","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306352","display_name":"Georgia Cancer Coalition","ror":"https://ror.org/0009gvn90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W1975956815","https://openalex.org/W1988386267","https://openalex.org/W2017393825","https://openalex.org/W2033894515","https://openalex.org/W2060200379","https://openalex.org/W2067459741","https://openalex.org/W2073124504","https://openalex.org/W2083893771","https://openalex.org/W2107253678","https://openalex.org/W2109816469","https://openalex.org/W2110096996","https://openalex.org/W2112413671","https://openalex.org/W2117692326","https://openalex.org/W2123823520","https://openalex.org/W2132907499","https://openalex.org/W2140128370","https://openalex.org/W2145444543","https://openalex.org/W6658672958","https://openalex.org/W6668429514","https://openalex.org/W6671682117","https://openalex.org/W6676152653"],"related_works":["https://openalex.org/W4386427838","https://openalex.org/W2050790932","https://openalex.org/W2936957353","https://openalex.org/W2612183478","https://openalex.org/W3178760882","https://openalex.org/W3023906449","https://openalex.org/W3048357152","https://openalex.org/W2049189005","https://openalex.org/W2999082355","https://openalex.org/W4386428778"],"abstract_inverted_index":{"Early":[0],"detection":[1,26],"of":[2,15,27,32,38],"oral":[3,28],"cancer":[4,46,87],"and":[5,13,76,85],"its":[6],"curable":[7],"precursors":[8],"can":[9],"improve":[10],"patient":[11],"survival":[12],"quality":[14],"life.":[16],"Hyperspectral":[17],"imaging":[18],"(HSI)":[19],"holds":[20],"the":[21],"potential":[22],"for":[23,44,57],"noninvasive":[24],"early":[25],"cancer.":[29],"The":[30,67],"quantification":[31],"tissue":[33],"chromophores":[34],"by":[35,72],"spectral":[36],"unmixing":[37],"hyperspectral":[39,59,74,80],"images":[40,60,75,81],"could":[41],"provide":[42],"insights":[43],"evaluating":[45],"progression.":[47],"In":[48],"this":[49],"study,":[50],"non-negative":[51],"matrix":[52],"factorization":[53],"has":[54,69],"been":[55,70],"applied":[56],"decomposing":[58],"into":[61],"physiologically":[62],"meaningful":[63],"chromophore":[64],"concentration":[65],"maps.":[66],"approach":[68],"validated":[71],"computer-simulated":[73],"in":[77],"vivo":[78],"tumor":[79],"from":[82],"a":[83],"head":[84],"neck":[86],"animal":[88],"model.":[89]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}