{"id":"https://openalex.org/W2050534254","doi":"https://doi.org/10.1117/12.2082291","title":"4DCBCT-based motion modeling and 3D fluoroscopic image generation for lung cancer radiotherapy","display_name":"4DCBCT-based motion modeling and 3D fluoroscopic image generation for lung cancer radiotherapy","publication_year":2015,"publication_date":"2015-03-18","ids":{"openalex":"https://openalex.org/W2050534254","doi":"https://doi.org/10.1117/12.2082291","mag":"2050534254"},"language":"en","primary_location":{"id":"doi:10.1117/12.2082291","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082291","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002516404","display_name":"Salam Dhou","orcid":"https://orcid.org/0000-0002-8143-6417"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salam Dhou","raw_affiliation_strings":["Brigham and Women's Hospital (United States)","Dana-Farber Cancer Institute (United States)","Harvard Medical School (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital (United States)","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109260283","display_name":"Martina Hurwitz","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martina Hurwitz","raw_affiliation_strings":["Brigham and Women's Hospital (United States)","Dana-Farber Cancer Institute (United States)","Harvard Medical School (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital (United States)","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pankaj Mishra","orcid":null},"institutions":[{"id":"https://openalex.org/I46603895","display_name":"Varian Medical Systems (United States)","ror":"https://ror.org/05yab6874","country_code":"US","type":"company","lineage":["https://openalex.org/I46603895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Mishra","raw_affiliation_strings":["Varian Medical Systems (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Varian Medical Systems (United States)","institution_ids":["https://openalex.org/I46603895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103527133","display_name":"Ross Berbeco","orcid":null},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross Berbeco","raw_affiliation_strings":["Brigham and Women's Hospital (United States)","Dana-Farber Cancer Institute (United States)","Harvard Medical School (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital (United States)","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026273809","display_name":"John H. Lewis","orcid":"https://orcid.org/0000-0002-5111-1865"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Lewis","raw_affiliation_strings":["Brigham and Women's Hospital (United States)","Dana-Farber Cancer Institute (United States)","Harvard Medical School (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital (United States)","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute (United States)","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School (United States)","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8373,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75325645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9415","issue":null,"first_page":"941510","last_page":"941510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imaging-phantom","display_name":"Imaging phantom","score":0.6641879081726074},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5888023376464844},{"id":"https://openalex.org/keywords/percentile","display_name":"Percentile","score":0.5564099550247192},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5386078357696533},{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.47458386421203613},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4624967575073242},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.42537304759025574},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.37012624740600586},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.27715417742729187},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.20960789918899536},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1385926604270935},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.11103382706642151}],"concepts":[{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.6641879081726074},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5888023376464844},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.5564099550247192},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5386078357696533},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.47458386421203613},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4624967575073242},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.42537304759025574},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.37012624740600586},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27715417742729187},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.20960789918899536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1385926604270935},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.11103382706642151}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2082291","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082291","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308932","display_name":"Radiological Society of North America","ror":"https://ror.org/00rj4x019"},{"id":"https://openalex.org/F4320309603","display_name":"Varian Medical Systems","ror":"https://ror.org/05yab6874"},{"id":"https://openalex.org/F4320323533","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1965829315","https://openalex.org/W1983281817","https://openalex.org/W1985076190","https://openalex.org/W1985587133","https://openalex.org/W1989413706","https://openalex.org/W1996657038","https://openalex.org/W1999440262","https://openalex.org/W2020061308","https://openalex.org/W2068214926","https://openalex.org/W2068877116","https://openalex.org/W2084664425","https://openalex.org/W2094229486","https://openalex.org/W2098904788","https://openalex.org/W2109182788","https://openalex.org/W2116956569","https://openalex.org/W2139303308","https://openalex.org/W2142867204","https://openalex.org/W2168632045","https://openalex.org/W3122435768","https://openalex.org/W6655210343","https://openalex.org/W6667583043"],"related_works":["https://openalex.org/W1550559433","https://openalex.org/W2189235034","https://openalex.org/W2417440389","https://openalex.org/W2319948171","https://openalex.org/W4244157427","https://openalex.org/W4233457764","https://openalex.org/W2471562626","https://openalex.org/W2461863667","https://openalex.org/W2295804706","https://openalex.org/W3168515805"],"abstract_inverted_index":{"A":[0],"method":[1,96],"is":[2,97],"developed":[3],"to":[4,20,26,59,90,179,214],"build":[5],"patient-specific":[6],"motion":[7,83,165,237],"models":[8,32,211,238],"based":[9,234],"on":[10,41,53,235],"4DCBCT":[11,57],"images":[12,24,233],"taken":[13],"at":[14,75,175,226],"treatment":[15,76,147,176,227],"time":[16,77,177],"and":[17,102,119,138,146,152,171,187,193,204,221,243],"use":[18],"them":[19],"generate":[21,91],"3D":[22,28,92,231],"time-varying":[23],"(referred":[25],"as":[27],"fluoroscopic":[29,93,232],"images).":[30],"Motion":[31],"are":[33,67,88,219],"built":[34],"by":[35,48,70],"applying":[36],"Principal":[37],"Component":[38],"Analysis":[39],"(PCA)":[40],"the":[42,82,113,149,153,182],"displacement":[43],"vector":[44],"fields":[45],"(DVFs)":[46],"estimated":[47,80],"performing":[49],"deformable":[50],"image":[51,134,154],"registration":[52],"each":[54],"phase":[55],"of":[56,136],"relative":[58],"a":[60],"reference":[61],"phase.":[62],"The":[63,85,95],"resulting":[64],"PCA":[65],"coefficients":[66,87],"optimized":[68,86],"iteratively":[69],"comparing":[71],"2D":[72],"projections":[73,79],"captured":[74],"with":[78],"using":[81,99,163,195,206],"model.":[84],"used":[89],"images.":[94],"evaluated":[98],"anthropomorphic":[100],"physical":[101,110],"digital":[103,130],"phantoms":[104,131],"reproducing":[105],"real":[106],"patient":[107],"trajectories.":[108],"For":[109,129],"phantom":[111],"datasets,":[112],"average":[114,150,183],"tumor":[115,172,222],"localization":[116],"error":[117,156],"(TLE)":[118],"(95th":[120,185],"percentile)":[121,186],"in":[122,158],"two":[123],"datasets":[124,160],"were":[125,161,189,200,212],"0.95":[126],"(2.2)":[127,202],"mm.":[128],"assuming":[132],"superior":[133],"quality":[135],"4DCT":[137,145],"no":[139],"anatomic":[140],"or":[141],"positioning":[142,169,220],"disparities":[143,170],"between":[144],"time,":[148],"TLE":[151,184],"intensity":[155],"(IIE)":[157],"six":[159],"smaller":[162],"4DCT-based":[164,196],"models.":[166],"When":[167],"simulating":[168],"baseline":[173,223],"shifts":[174],"compared":[178],"planning":[180],"4DCT,":[181],"IIE":[188],"4.2":[190],"(5.4)":[191],"mm":[192,203],"0.15":[194],"models,":[197],"while":[198],"they":[199],"1.2":[201],"0.10":[205],"4DCBCT-based":[207,210,236],"ones,":[208],"respectively.":[209],"shown":[213],"perform":[215],"better":[216],"when":[217],"there":[218],"shift":[224],"uncertainties":[225],"time.":[228],"Thus,":[229],"generating":[230],"can":[239],"capture":[240],"both":[241],"inter-":[242],"intra-":[244],"fraction":[245],"anatomical":[246],"changes":[247],"during":[248],"treatment.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
