{"id":"https://openalex.org/W1996991192","doi":"https://doi.org/10.1117/12.2082164","title":"Segmentation of microcystic macular edema in Cirrus OCT scans with an exploratory longitudinal study","display_name":"Segmentation of microcystic macular edema in Cirrus OCT scans with an exploratory longitudinal study","publication_year":2015,"publication_date":"2015-03-17","ids":{"openalex":"https://openalex.org/W1996991192","doi":"https://doi.org/10.1117/12.2082164","mag":"1996991192","pmid":"https://pubmed.ncbi.nlm.nih.gov/26023249"},"language":"en","primary_location":{"id":"doi:10.1117/12.2082164","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082164","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061875360","display_name":"Emily K. Swingle","orcid":null},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily K. Swingle","raw_affiliation_strings":["Department of Biomedical Engineering, The Ohio State University","Department of Biomedical Engineering (The Ohio State University)"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Biomedical Engineering (The Ohio State University)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103480360","display_name":"Andrew Lang","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Lang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The Johns Hopkins University","Dept. of Electrical and Computer Engineering The Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Dept. of Electrical and Computer Engineering The Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075622613","display_name":"Aaron Carass","orcid":"https://orcid.org/0000-0003-4939-5085"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Carass","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The Johns Hopkins University ; Department of Computer Science, The Johns Hopkins University","Department of Electrical and Computer Engineering, The Johns Hopkins University; Department of Computer Science, The Johns Hopkins University"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Johns Hopkins University ; Department of Computer Science, The Johns Hopkins University","institution_ids":[]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Johns Hopkins University; Department of Computer Science, The Johns Hopkins University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023759929","display_name":"Omar Al\u2010Louzi","orcid":"https://orcid.org/0000-0003-2260-5660"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Al-Louzi","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University School of Medicine","Department of Neurology, The Johns Hopkins University, School of Medicine"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University, School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052025260","display_name":"Shiv Saidha","orcid":"https://orcid.org/0000-0001-6387-0714"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiv Saidha","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University School of Medicine","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066682675","display_name":"Jerry L. Prince","orcid":"https://orcid.org/0000-0002-6553-0876"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry L. Prince","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The Johns Hopkins University","Johns\u00a0 Hopkins University, United States"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns\u00a0 Hopkins University, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061851273","display_name":"Peter A. Calabresi","orcid":"https://orcid.org/0000-0002-7776-6472"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Calabresi","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University School of Medicine","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5061875360"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":3.6939,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.92392972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9417","issue":null,"first_page":"94170P","last_page":"94170P"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.7422091960906982},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5331634283065796},{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.44000300765037537},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4322316646575928},{"id":"https://openalex.org/keywords/macular-edema","display_name":"Macular edema","score":0.43062007427215576},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.4092729091644287},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3841269314289093},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.35762012004852295},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.3384186625480652},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3262735605239868},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.09691405296325684}],"concepts":[{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.7422091960906982},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5331634283065796},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.44000300765037537},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4322316646575928},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.43062007427215576},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4092729091644287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3841269314289093},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.35762012004852295},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.3384186625480652},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3262735605239868},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09691405296325684},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2082164","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082164","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:26023249","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26023249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:3406262","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443694","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.75,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1982853080","https://openalex.org/W1993893886","https://openalex.org/W1998976161","https://openalex.org/W2000511084","https://openalex.org/W2038421253","https://openalex.org/W2038850290","https://openalex.org/W2083609416","https://openalex.org/W2121568944","https://openalex.org/W2127294620","https://openalex.org/W2313336038","https://openalex.org/W2480705741","https://openalex.org/W6671080933"],"related_works":["https://openalex.org/W2362796209","https://openalex.org/W2348498086","https://openalex.org/W1014602304","https://openalex.org/W1033756233","https://openalex.org/W2119498694","https://openalex.org/W1977334515","https://openalex.org/W747244433","https://openalex.org/W2037746501","https://openalex.org/W2093210804","https://openalex.org/W1993625448"],"abstract_inverted_index":{"Microcystic":[0],"macular":[1],"edema":[2],"(MME)":[3],"is":[4,83],"a":[5,33,100,155,173,183,190],"term":[6],"used":[7],"to":[8,42,52,145,166,199,202,218],"describe":[9],"pseudocystic":[10],"spaces":[11],"in":[12,26,85,96,99,113,126,229],"the":[13,19,69,92,204,224,230],"inner":[14],"nuclear":[15],"layer":[16],"(INL)":[17],"of":[18,35,74,91,103,163,180,186,194,207],"human":[20],"retina.":[21],"It":[22],"has":[23,172],"been":[24],"noted":[25],"multiple":[27],"sclerosis":[28],"(MS)":[29],"as":[30,32,94],"well":[31],"variety":[34],"other":[36],"diseases.":[37],"The":[38,56,170,209],"processes":[39],"that":[40],"lead":[41],"MME":[43,61,82,138,178,225],"formation":[44],"and":[45,71,182,214],"their":[46],"change":[47],"over":[48,197],"time":[49],"have":[50,219],"yet":[51],"be":[53,110,122],"explained":[54],"sufficiently.":[55],"low":[57],"rate":[58,176],"at":[59],"which":[60],"occurs":[62],"within":[63],"such":[64],"diverse":[65],"patient":[66,232],"groups":[67],"makes":[68],"identification":[70,139,179],"consistent":[72],"quantification":[73],"this":[75,131],"pathology":[76],"important":[77],"for":[78,177],"developing":[79],"patient-specific":[80],"prognoses.":[81],"observed":[84],"optical":[86],"coherence":[87],"tomography":[88],"(OCT)":[89],"scans":[90,144],"retina":[93],"changes":[95,206],"light":[97],"reflectivity":[98],"pattern":[101],"suggestive":[102],"fluid":[104],"accumulations":[105],"called":[106],"pseudocysts.":[107],"Pseudocysts":[108],"can":[109,121],"readily":[111],"identified":[112],"higher":[114],"signal-to-noise":[115],"ratio":[116],"(SNR)":[117],"images,":[118],"however":[119],"pseudocysts":[120],"indistinguishable":[123],"from":[124],"noise":[125],"lower":[127,147],"SNR":[128],"scans.":[129,151],"In":[130],"work,":[132],"we":[133],"expand":[134],"upon":[135],"our":[136],"earlier":[137],"methods":[140],"on":[141,160],"Spectralis":[142],"OCT":[143,150],"handle":[146],"quality":[148],"Cirrus":[149],"Our":[152],"approach":[153],"uses":[154],"random":[156],"forest":[157],"classifier,":[158],"trained":[159],"manual":[161],"segmentation":[162],"ten":[164],"subjects,":[165],"automatically":[167],"detect":[168],"MME.":[169,208],"algorithm":[171],"true":[174],"positive":[175],"0.95":[181],"Dice":[184],"score":[185],"0.79.":[187],"We":[188],"include":[189],"preliminary":[191],"longitudinal":[192,205],"study":[193],"three":[195],"patients":[196,210],"four":[198],"five":[200],"years":[201],"explore":[203],"with":[211,233],"relapsing-remitting":[212],"MS":[213],"neuromyelitis":[215],"optica":[216],"appear":[217],"dynamic":[220],"pseudocyst":[221],"volumes,":[222],"while":[223],"volume":[226],"appears":[227],"stable":[228],"one":[231],"primary":[234],"progressive":[235],"MS.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}