{"id":"https://openalex.org/W2072338072","doi":"https://doi.org/10.1117/12.2082054","title":"Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer","display_name":"Quantitative assessment of smoking-induced emphysema progression in longitudinal CT screening for lung cancer","publication_year":2015,"publication_date":"2015-03-20","ids":{"openalex":"https://openalex.org/W2072338072","doi":"https://doi.org/10.1117/12.2082054","mag":"2072338072"},"language":"en","primary_location":{"id":"doi:10.1117/12.2082054","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082054","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085175647","display_name":"Hidenobu Suzuki","orcid":"https://orcid.org/0000-0002-2605-1100"},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Suzuki","raw_affiliation_strings":["The University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110357648","display_name":"R Mizuguchi","orcid":null},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Mizuguchi","raw_affiliation_strings":["The University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113548875","display_name":"Mikio Matsuhiro","orcid":null},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Matsuhiro","raw_affiliation_strings":["The University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003127183","display_name":"Yoshiki Kawata","orcid":"https://orcid.org/0000-0003-0437-8740"},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Kawata","raw_affiliation_strings":["The University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013719582","display_name":"Noboru Niki","orcid":null},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Niki","raw_affiliation_strings":["The University of Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085036473","display_name":"Yasutaka Nakano","orcid":"https://orcid.org/0000-0001-7516-8690"},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Nakano","raw_affiliation_strings":[", Shiga University of Medical Science, , , , , , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Shiga University of Medical Science, , , , , , Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018607947","display_name":"Hironobu Ohmatsu","orcid":"https://orcid.org/0000-0001-5423-4230"},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Ohmatsu","raw_affiliation_strings":["National Cancer Ctr. Hospital East (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Ctr. Hospital East (Japan)","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083873485","display_name":"Masahiro Kusumoto","orcid":"https://orcid.org/0000-0001-8675-4732"},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Kusumoto","raw_affiliation_strings":["National Cancer Ctr. Hospital East (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Ctr. Hospital East (Japan)","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046982511","display_name":"Takaaki Tsuchida","orcid":"https://orcid.org/0000-0002-4878-1956"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Tsuchida","raw_affiliation_strings":["National Cancer Ctr. Hospital  (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Ctr. Hospital  (Japan)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108236558","display_name":"K. Eguchi","orcid":null},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Eguchi","raw_affiliation_strings":["Teikyo University, , , , , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teikyo University, , , , , Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005531754","display_name":"Masahiro Kaneko","orcid":"https://orcid.org/0000-0002-5117-5447"},"institutions":[{"id":"https://openalex.org/I4210095161","display_name":"Japan Industrial Safety and Health Association","ror":"https://ror.org/00jtmm480","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210095161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Kaneko","raw_affiliation_strings":["Tokyo Health Service Association (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Health Service Association (Japan)","institution_ids":["https://openalex.org/I4210095161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113547866","display_name":"N. Moriyama","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Moriyama","raw_affiliation_strings":["Tokyo Midtown Clinic Health Screening Ctr. (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Midtown Clinic Health Screening Ctr. (Japan)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4793,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69936429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9414","issue":null,"first_page":"94142O","last_page":"94142O"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7965937852859497},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.7939972877502441},{"id":"https://openalex.org/keywords/lung-cancer-screening","display_name":"Lung cancer screening","score":0.6818019151687622},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.6029605269432068},{"id":"https://openalex.org/keywords/pulmonary-emphysema","display_name":"Pulmonary emphysema","score":0.5897043347358704},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5189706683158875},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.5130609273910522},{"id":"https://openalex.org/keywords/stage","display_name":"Stage (stratigraphy)","score":0.5060879588127136},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3140016794204712},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2693731188774109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7965937852859497},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7939972877502441},{"id":"https://openalex.org/C2777405583","wikidata":"https://www.wikidata.org/wiki/Q6704277","display_name":"Lung cancer screening","level":3,"score":0.6818019151687622},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.6029605269432068},{"id":"https://openalex.org/C2992836489","wikidata":"https://www.wikidata.org/wiki/Q188605","display_name":"Pulmonary emphysema","level":3,"score":0.5897043347358704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5189706683158875},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5130609273910522},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5060879588127136},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3140016794204712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2693731188774109},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2082054","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082054","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8899999856948853,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2003336500","https://openalex.org/W2019836388","https://openalex.org/W2042902143","https://openalex.org/W2054931962","https://openalex.org/W2065841018","https://openalex.org/W2070651691","https://openalex.org/W2075006953","https://openalex.org/W2079648272","https://openalex.org/W2091048143","https://openalex.org/W2116954144","https://openalex.org/W2117489289","https://openalex.org/W2117786052","https://openalex.org/W2122532950","https://openalex.org/W2130039652","https://openalex.org/W2130574899","https://openalex.org/W2136234749","https://openalex.org/W2137459475","https://openalex.org/W2139507936","https://openalex.org/W2157574022","https://openalex.org/W4211263216","https://openalex.org/W6655555547","https://openalex.org/W6666942591","https://openalex.org/W6668327823","https://openalex.org/W6670746163","https://openalex.org/W6673232376","https://openalex.org/W6677527149","https://openalex.org/W6680928457"],"related_works":["https://openalex.org/W2503350049","https://openalex.org/W2329386257","https://openalex.org/W2005585032","https://openalex.org/W2397616145","https://openalex.org/W4386457524","https://openalex.org/W2738392531","https://openalex.org/W3119394462","https://openalex.org/W4388045257","https://openalex.org/W4229030861","https://openalex.org/W2009875305"],"abstract_inverted_index":{"Computed":[0],"tomography":[1],"has":[2],"been":[3],"used":[4],"for":[5,62,112,160],"assessing":[6],"structural":[7],"abnormalities":[8],"associated":[9],"with":[10,135],"emphysema.":[11],"It":[12],"is":[13,129],"important":[14],"to":[15,104,131],"develop":[16],"a":[17],"robust":[18],"CT":[19,57,74,110,158],"based":[20],"imaging":[21],"biomarker":[22],"that":[23,127],"would":[24],"allow":[25],"quantification":[26],"of":[27,37,45,67,83,90,98,138,146,154],"emphysema":[28,40,84,139,156],"progression":[29,41,137],"in":[30,59,107,150,157],"early":[31,155],"stage.":[32],"This":[33,100,142],"paper":[34,143],"presents":[35],"effect":[36],"smoking":[38],"on":[39],"using":[42],"annual":[43,92],"changes":[44,93],"low":[46],"attenuation":[47],"volume":[48],"(LAV)":[49],"by":[50,87,95],"each":[51],"lung":[52,63,108,161],"lobe":[53],"acquired":[54],"from":[55],"low-dose":[56],"images":[58],"longitudinal":[60],"screening":[61,111,159],"cancer.":[64,162],"The":[65,124],"percentage":[66],"LAV":[68],"(LAV%)":[69],"was":[70,85,102],"measured":[71],"after":[72],"applying":[73],"value":[75],"threshold":[76],"method":[77,101,149],"and":[78,120,152],"small":[79],"noise":[80],"reduction.":[81],"Progression":[82],"assessed":[86],"statistical":[88],"analysis":[89],"the":[91,147],"represented":[94],"linear":[96],"regression":[97],"LAV%.":[99],"applied":[103],"215":[105],"participants":[106],"cancer":[109],"five":[113],"years":[114],"(18":[115],"nonsmokers,":[116],"85":[117],"past":[118],"smokers,":[119],"112":[121],"current":[122,133],"smokers).":[123],"results":[125],"showed":[126],"LAV%":[128],"useful":[130],"classify":[132],"smokers":[134],"rapid":[136],"(0.2%/year,":[140],"p<0.05).":[141],"demonstrates":[144],"effectiveness":[145],"proposed":[148],"diagnosis":[151],"prognosis":[153]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}