{"id":"https://openalex.org/W2038535389","doi":"https://doi.org/10.1117/12.2082032","title":"Robust detection of multiple sclerosis lesions from intensity-normalized multi-channel MRI","display_name":"Robust detection of multiple sclerosis lesions from intensity-normalized multi-channel MRI","publication_year":2015,"publication_date":"2015-03-20","ids":{"openalex":"https://openalex.org/W2038535389","doi":"https://doi.org/10.1117/12.2082032","mag":"2038535389"},"language":"en","primary_location":{"id":"doi:10.1117/12.2082032","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082032","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://inserm.hal.science/inserm-01127692","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056832396","display_name":"Yogesh Karpate","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387152452","display_name":"Empenn","ror":"https://ror.org/02hp31992","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I205703379","https://openalex.org/I2802204017","https://openalex.org/I2802519937","https://openalex.org/I28221208","https://openalex.org/I4210127572","https://openalex.org/I4210133778","https://openalex.org/I4210159245","https://openalex.org/I4387152452","https://openalex.org/I56067802","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yogesh Karpate","raw_affiliation_strings":["VISAGES: INSERM, CNRS, INRIA, Univ. of Rennes 1 (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VISAGES: INSERM, CNRS, INRIA, Univ. of Rennes 1 (France)","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I4387152452","https://openalex.org/I56067802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032667893","display_name":"Olivier Commowick","orcid":"https://orcid.org/0000-0001-7345-6752"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387152452","display_name":"Empenn","ror":"https://ror.org/02hp31992","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I205703379","https://openalex.org/I2802204017","https://openalex.org/I2802519937","https://openalex.org/I28221208","https://openalex.org/I4210127572","https://openalex.org/I4210133778","https://openalex.org/I4210159245","https://openalex.org/I4387152452","https://openalex.org/I56067802","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Commowick","raw_affiliation_strings":["VISAGES: INSERM, CNRS, INRIA, Univ. of Rennes 1 (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VISAGES: INSERM, CNRS, INRIA, Univ. of Rennes 1 (France)","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I4387152452","https://openalex.org/I56067802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066059428","display_name":"Christian Barillot","orcid":"https://orcid.org/0000-0002-1589-7696"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387152452","display_name":"Empenn","ror":"https://ror.org/02hp31992","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I205703379","https://openalex.org/I2802204017","https://openalex.org/I2802519937","https://openalex.org/I28221208","https://openalex.org/I4210127572","https://openalex.org/I4210133778","https://openalex.org/I4210159245","https://openalex.org/I4387152452","https://openalex.org/I56067802","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Barillot","raw_affiliation_strings":["VISAGES: INSERM, CNRS, INRIA, Univ. of Rennes 1 (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VISAGES: INSERM, CNRS, INRIA, Univ. of Rennes 1 (France)","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I4387152452","https://openalex.org/I56067802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"9413","issue":null,"first_page":"941314","last_page":"941314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10688","display_name":"Image and Signal Denoising Methods","score":0.9668999910354614,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9595999717712402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.7896783351898193},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6075208187103271},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5349055528640747},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.5149153470993042},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4705807566642761},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.45974332094192505},{"id":"https://openalex.org/keywords/clinically-isolated-syndrome","display_name":"Clinically isolated syndrome","score":0.4582277238368988},{"id":"https://openalex.org/keywords/mixture-model","display_name":"Mixture model","score":0.41944658756256104},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3441043496131897},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.23238125443458557}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7896783351898193},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6075208187103271},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5349055528640747},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5149153470993042},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4705807566642761},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.45974332094192505},{"id":"https://openalex.org/C2781028063","wikidata":"https://www.wikidata.org/wiki/Q338802","display_name":"Clinically isolated syndrome","level":3,"score":0.4582277238368988},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.41944658756256104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3441043496131897},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.23238125443458557},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2082032","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2082032","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.851.6843","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.851.6843","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.hal.inserm.fr/inserm-01127692/document/","raw_type":"text"},{"id":"pmh:oai:HAL:inserm-01127692v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-01127692","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SPIE Medical Imaging, Feb 2015, Orlando, United States","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:HAL:inserm-01127692v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-01127692","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SPIE Medical Imaging, Feb 2015, Orlando, United States","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1808712535","https://openalex.org/W1871230255","https://openalex.org/W1959409813","https://openalex.org/W1973457617","https://openalex.org/W2014035569","https://openalex.org/W2049633694","https://openalex.org/W2050468619","https://openalex.org/W2071881327","https://openalex.org/W2079158221","https://openalex.org/W2081663123","https://openalex.org/W2102290518","https://openalex.org/W2110065044","https://openalex.org/W2117340355","https://openalex.org/W2142592339","https://openalex.org/W4256188663","https://openalex.org/W6638774405","https://openalex.org/W6639284656","https://openalex.org/W6653819045","https://openalex.org/W6676591658","https://openalex.org/W7048738093"],"related_works":["https://openalex.org/W1534979851","https://openalex.org/W3206954403","https://openalex.org/W2910192441","https://openalex.org/W2177443840","https://openalex.org/W2979780168","https://openalex.org/W2516913217","https://openalex.org/W2010588274","https://openalex.org/W2912560294","https://openalex.org/W2173847724","https://openalex.org/W2388894913"],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"is":[3,112],"a":[4,21,47,64,74,98,137],"disease":[5,37,43],"with":[6,164],"heterogeneous":[7],"evolution":[8],"among":[9],"the":[10,25,32,42,81,116,124,147,156,171,189,208],"patients.":[11],"Quantitative":[12],"analysis":[13,23],"of":[14,24,34,36,41,50,83,100,123,149,158,161,191,210],"longitudinal":[15],"Magnetic":[16],"Resonance":[17],"Images":[18],"(MRI)":[19],"provides":[20],"spatial":[22],"brain":[26],"tissues":[27],"which":[28],"may":[29],"lead":[30,45],"to":[31,46,67,87,114,166,177],"discovery":[33,49],"biomarkers":[35],"evolution.":[38],"Better":[39],"understanding":[40],"will":[44],"better":[48],"pathogenic":[51],"mechanisms,":[52],"allowing":[53,175],"for":[54,179],"patient-adapted":[55],"therapeutic":[56],"strategies.":[57],"To":[58],"characterize":[59],"MS":[60,95,150,162,211],"lesions,":[61],"we":[62],"propose":[63],"novel":[65],"paradigm":[66],"detect":[68,88],"white":[69,184],"matter":[70],"lesions":[71,190,205],"based":[72],"on":[73],"statistical":[75],"framework.":[76],"It":[77],"aims":[78],"at":[79],"studying":[80],"benefits":[82],"using":[84,136],"multi-channel":[85,159],"MRI":[86,160],"statistically":[89],"significant":[90,202],"differences":[91,180,203],"between":[92],"each":[93,192],"individual":[94],"patient":[96],"and":[97,127,187],"database":[99],"control":[101,172],"subjects.":[102],"This":[103],"framework":[104],"consists":[105],"in":[106,181,186,204],"two":[107],"components.":[108],"First,":[109],"intensity":[110,118,131],"standardization":[111],"conducted":[113],"minimize":[115],"inter-subject":[117],"difference":[119],"arising":[120],"from":[121,170],"variability":[122],"acquisition":[125],"process":[126],"different":[128],"scanners.":[129],"The":[130,152],"normalization":[132],"maps":[133],"parameters":[134],"obtained":[135],"robust":[138],"Gaussian":[139],"Mixture":[140],"Model":[141],"(GMM)":[142],"estimation":[143],"not":[144],"affected":[145],"by":[146],"presence":[148],"lesions.":[151],"second":[153],"part":[154],"studies":[155],"comparison":[157],"patients":[163],"respect":[165],"an":[167],"atlas":[168],"built":[169],"subjects,":[173],"thereby":[174],"us":[176],"look":[178],"normal":[182],"appearing":[183],"matter,":[185],"around":[188],"patient.":[193],"Experimental":[194],"results":[195,209],"demonstrate":[196],"that":[197],"our":[198],"technique":[199],"accurately":[200],"detects":[201],"consequently":[206],"improving":[207],"lesion":[212],"detection.":[213]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
