{"id":"https://openalex.org/W4242147367","doi":"https://doi.org/10.1117/12.2081506","title":"Segmentation of digitized histological sections for vasculature quantification in the mouse hind limb","display_name":"Segmentation of digitized histological sections for vasculature quantification in the mouse hind limb","publication_year":2015,"publication_date":"2015-03-19","ids":{"openalex":"https://openalex.org/W4242147367","doi":"https://doi.org/10.1117/12.2081506"},"language":"en","primary_location":{"id":"doi:10.1117/12.2081506","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2081506","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083904441","display_name":"Yiwen Xu","orcid":"https://orcid.org/0000-0003-0509-7350"},"institutions":[{"id":"https://openalex.org/I4210105758","display_name":"Robarts Clinical Trials","ror":"https://ror.org/01e36dv41","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4210105758","https://openalex.org/I4405252475"]},{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Yiwen Xu","raw_affiliation_strings":["Robarts Research Institute (Canada)","The Univ. of Western Ontario (Canada)"],"affiliations":[{"raw_affiliation_string":"Robarts Research Institute (Canada)","institution_ids":["https://openalex.org/I4210105758"]},{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026289208","display_name":"J. Geoffrey Pickering","orcid":"https://orcid.org/0000-0001-6474-3274"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I4210105758","display_name":"Robarts Clinical Trials","ror":"https://ror.org/01e36dv41","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4210105758","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. G. Pickering","raw_affiliation_strings":["Robarts Research Institute (Canada)","The Univ. of Western Ontario (Canada)"],"affiliations":[{"raw_affiliation_string":"Robarts Research Institute (Canada)","institution_ids":["https://openalex.org/I4210105758"]},{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100910585","display_name":"Zengxuan Nong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105758","display_name":"Robarts Clinical Trials","ror":"https://ror.org/01e36dv41","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4210105758","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zengxuan Nong","raw_affiliation_strings":["Robarts Research Institute (Canada)"],"affiliations":[{"raw_affiliation_string":"Robarts Research Institute (Canada)","institution_ids":["https://openalex.org/I4210105758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113914224","display_name":"Aaron D. Ward","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aaron D. Ward","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083904441"],"corresponding_institution_ids":["https://openalex.org/I125749732","https://openalex.org/I4210105758"],"apc_list":null,"apc_paid":null,"fwci":0.5523,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.77288868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"9420","issue":null,"first_page":"942003","last_page":"942003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.9758999943733215,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6786878705024719},{"id":"https://openalex.org/keywords/stain","display_name":"Stain","score":0.5654878616333008},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.5433725118637085},{"id":"https://openalex.org/keywords/histology","display_name":"Histology","score":0.5316807627677917},{"id":"https://openalex.org/keywords/lumen","display_name":"Lumen (anatomy)","score":0.49046823382377625},{"id":"https://openalex.org/keywords/h-e-stain","display_name":"H&E stain","score":0.4565443992614746},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4535570442676544},{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.41336753964424133},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.39591604471206665},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.3540550172328949},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34666332602500916},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2952991724014282},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27441003918647766},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16440331935882568}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6786878705024719},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.5654878616333008},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5433725118637085},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.5316807627677917},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.49046823382377625},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.4565443992614746},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4535570442676544},{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.41336753964424133},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.39591604471206665},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.3540550172328949},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34666332602500916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2952991724014282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27441003918647766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16440331935882568},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2081506","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2081506","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.49000000953674316}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W581127481","https://openalex.org/W1597336200","https://openalex.org/W2079807819","https://openalex.org/W2088526319","https://openalex.org/W2129916129","https://openalex.org/W2133059825","https://openalex.org/W2139479159","https://openalex.org/W2158008371","https://openalex.org/W4243950387","https://openalex.org/W4250362079","https://openalex.org/W4255094308","https://openalex.org/W4255355362","https://openalex.org/W4256188663","https://openalex.org/W6635816984"],"related_works":["https://openalex.org/W4311305828","https://openalex.org/W4384826841","https://openalex.org/W4310665281","https://openalex.org/W4390098721","https://openalex.org/W2063882352","https://openalex.org/W62528080","https://openalex.org/W2043744435","https://openalex.org/W2193165651","https://openalex.org/W2015326638","https://openalex.org/W2138378837"],"abstract_inverted_index":{"Characteristics":[0],"of":[1,13,22,44,53,79,87,96,125,129,140,199,226,236],"microvasculature":[2],"can":[3],"be":[4],"revealed":[5],"by":[6,110,123],"immunohistochemical":[7],"tissue":[8,159],"staining,":[9,82],"but":[10],"manual":[11],"quantification":[12],"these":[14,108],"characteristics":[15],"on":[16,24,50,90,98,135,154,189],"whole-slide":[17],"images":[18],"containing":[19],"potentially":[20],"hundreds":[21],"vessels":[23,89,178],"each":[25],"is":[26],"tedious":[27],"and":[28,38,56,93,166,171,182,212,223],"subject":[29],"to":[30,36,73,113,184],"operator":[31],"variability.":[32],"Our":[33],"objective":[34],"was":[35],"develop":[37],"validate":[39],"a":[40,136,190,195],"fully":[41],"automated":[42,105,186,234],"segmentation":[43,75,106,176,187,235],"the":[45,77,91,115,126,130,185,205,209,213,227,233,237],"vascular":[46,228,238],"smooth":[47,65,239],"muscle":[48,66],"layer":[49],"whole-section":[51],"histology":[52,142],"wild":[54,191,210],"type":[55,192,211],"regenerated":[57,214],"post-ischemia":[58],"mouse":[59],"hind":[60],"limb":[61],"microvasculature,":[62],"stained":[63],"for":[64],"using":[67],"3,3'-Diaminobenzidine":[68],"(DAB)":[69],"immunostain.":[70],"Major":[71],"challenges":[72],"this":[74],"are":[76,230],"irregularity":[78],"vessel":[80,102,119,131,163,167,206],"wall":[81,132,164],"resulting":[83],"in":[84,146,160,204,216],"apparent":[85],"fragmentation":[86],"intact":[88],"images,":[92],"artefactual":[94,149],"appearance":[95],"stain":[97],"structures":[99],"other":[100],"than":[101],"walls.":[103],"The":[104,162],"localizes":[107],"fragments":[109,150],"color":[111],"deconvolution":[112],"isolate":[114],"DAB":[116],"stain.":[117],"Complete":[118],"walls":[120],"were":[121,151,173,179,202],"reconstituted":[122],"joining":[124],"topological":[127],"skeletons":[128],"fragments.":[133],"Based":[134],"highly":[137],"accurate":[138,224],"registration":[139],"serial":[141],"sections":[143],"previously":[144],"developed":[145],"our":[147],"lab,":[148],"removed":[152],"based":[153],"measured":[155],"incoherence":[156],"with":[157,194,232],"neighboring":[158],"3D.":[161],"thickness,":[165],"count,":[168],"density,":[169],"area,":[170],"perimeter":[172],"quantified.":[174],"For":[175],"validation,":[177],"manually":[180],"delineated":[181],"compared":[183],"approach":[188],"mouse,":[193],"dice":[196],"similarity":[197],"coefficient":[198],"0.84.":[200],"Differences":[201],"observed":[203],"measurements":[207],"between":[208],"vasculature":[215],"post-ischemic":[217],"mice,":[218],"as":[219],"expected.":[220],"Fully":[221],"automatic":[222],"measures":[225],"morphology":[229],"feasible":[231],"muscle.":[240]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
