{"id":"https://openalex.org/W2023212315","doi":"https://doi.org/10.1117/12.2077746","title":"An adaptive algorithm for detection of multiple-type, positively stained nuclei in IHC images with minimal prior information: application to OLIG2 staining gliomas","display_name":"An adaptive algorithm for detection of multiple-type, positively stained nuclei in IHC images with minimal prior information: application to OLIG2 staining gliomas","publication_year":2015,"publication_date":"2015-03-19","ids":{"openalex":"https://openalex.org/W2023212315","doi":"https://doi.org/10.1117/12.2077746","mag":"2023212315"},"language":"en","primary_location":{"id":"doi:10.1117/12.2077746","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2077746","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038676174","display_name":"Hatice \u00c7\u0131nar Akak\u0131n","orcid":null},"institutions":[{"id":"https://openalex.org/I133743585","display_name":"Anadolu University","ror":"https://ror.org/05nz37n09","country_code":"TR","type":"education","lineage":["https://openalex.org/I133743585"]},{"id":"https://openalex.org/I204585392","display_name":"Usak University","ror":"https://ror.org/05es91y67","country_code":"TR","type":"education","lineage":["https://openalex.org/I204585392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hatice C. Akakin","raw_affiliation_strings":["Anadolu Univ. (Turkey)","Anadolu University , Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anadolu Univ. (Turkey)","institution_ids":["https://openalex.org/I133743585"]},{"raw_affiliation_string":"Anadolu University , Turkey","institution_ids":["https://openalex.org/I204585392","https://openalex.org/I133743585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045630692","display_name":"Hamza N. Gokozan","orcid":"https://orcid.org/0000-0002-8782-9908"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamza Gokozan","raw_affiliation_strings":["The Ohio State Univ. (United States)","The Ohio State University UNITED STATES"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State Univ. (United States)","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University UNITED STATES","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019267884","display_name":"Jos\u00e9 Javier Otero","orcid":"https://orcid.org/0000-0003-0680-4520"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Otero","raw_affiliation_strings":["The Ohio State Univ. (United States)","The Ohio State University UNITED STATES"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State Univ. (United States)","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University UNITED STATES","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077316017","display_name":"Metin N. G\u00fcrcan","orcid":"https://orcid.org/0000-0002-2421-8229"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Metin N. Gurcan","raw_affiliation_strings":["The Ohio State Univ. (United States)","The Ohio State University UNITED STATES"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State Univ. (United States)","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University UNITED STATES","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8903,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.82703617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9420","issue":null,"first_page":"942007","last_page":"942007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olig2","display_name":"OLIG2","score":0.8079085946083069},{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.6282951235771179},{"id":"https://openalex.org/keywords/immunoperoxidase","display_name":"Immunoperoxidase","score":0.5687538385391235},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5408890247344971},{"id":"https://openalex.org/keywords/stain","display_name":"Stain","score":0.4980134963989258},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4771004319190979},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4188944697380066},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3732607662677765},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34396082162857056},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.32861170172691345},{"id":"https://openalex.org/keywords/oligodendrocyte","display_name":"Oligodendrocyte","score":0.15889927744865417},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13088685274124146},{"id":"https://openalex.org/keywords/myelin","display_name":"Myelin","score":0.09931421279907227},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.08724352717399597}],"concepts":[{"id":"https://openalex.org/C2779055221","wikidata":"https://www.wikidata.org/wiki/Q18035130","display_name":"OLIG2","level":5,"score":0.8079085946083069},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6282951235771179},{"id":"https://openalex.org/C128102431","wikidata":"https://www.wikidata.org/wiki/Q6005550","display_name":"Immunoperoxidase","level":4,"score":0.5687538385391235},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5408890247344971},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.4980134963989258},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4771004319190979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4188944697380066},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3732607662677765},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34396082162857056},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.32861170172691345},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.15889927744865417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13088685274124146},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.09931421279907227},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08724352717399597},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2077746","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2077746","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.6499999761581421,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W155107415","https://openalex.org/W1561442812","https://openalex.org/W1966129192","https://openalex.org/W1968498741","https://openalex.org/W1970120446","https://openalex.org/W1990624126","https://openalex.org/W2026541878","https://openalex.org/W2034501924","https://openalex.org/W2037402988","https://openalex.org/W2043034051","https://openalex.org/W2051765910","https://openalex.org/W2056245524","https://openalex.org/W2061554822","https://openalex.org/W2081314633","https://openalex.org/W2088169690","https://openalex.org/W2094938045","https://openalex.org/W2103243046","https://openalex.org/W2116040950","https://openalex.org/W2119774436","https://openalex.org/W2123269393","https://openalex.org/W2142332605","https://openalex.org/W2163181242","https://openalex.org/W2171997925","https://openalex.org/W2505399031","https://openalex.org/W6656987227","https://openalex.org/W6661046421","https://openalex.org/W6663446329","https://openalex.org/W6685079154"],"related_works":["https://openalex.org/W1705932695","https://openalex.org/W90289501","https://openalex.org/W2040366372","https://openalex.org/W2043390473","https://openalex.org/W2336199709","https://openalex.org/W3040343047","https://openalex.org/W2362126043","https://openalex.org/W2352791572","https://openalex.org/W2097952607","https://openalex.org/W3037752552"],"abstract_inverted_index":{"We":[0],"propose":[1],"a":[2,107,114,178,307],"method":[3,195],"to":[4,86,99,121,138,159,188,200,258,260,285],"detect":[5,100,201,286],"and":[6,10,28,38,44,65,79,126,146,169,213,240,252,293,301],"segment":[7,122],"the":[8,47,69,101,128,134,163,166,170,173,185,207,225,238,261,269,279,283],"oligodendrocytes":[9,39,72],"gliomas":[11,55],"in":[12,42,82,90,264,278],"OLIG2":[13,51,102],"immunoperoxidase":[14],"stained":[15,52,203],"tissue":[16,48,53,179,311],"sections.":[17],"Segmentation":[18],"of":[19,31,109,130,165,172,184,209,233,242,282,309],"cell":[20,104,124,131,135,148,214,220,276],"nuclei":[21,61,77,136,144,174,245],"is":[22,98,120,187,289],"essential":[23],"for":[24,306],"automatic,":[25],"fast,":[26],"accurate":[27],"consistent":[29],"analysis":[30],"pathology":[32],"images.":[33],"In":[34,50,157],"general,":[35],"glioma":[36,87,139,190],"cells":[37,88,191,204,212,288],"mostly":[40],"differ":[41,175],"shape":[43],"size":[45,83],"within":[46,106,177],"slide.":[49,116],"images,":[54],"are":[56,80,222],"represented":[57],"with":[58,62,154,197,224,313],"irregularly":[59],"shaped":[60],"varying":[63],"sizes":[64],"brown":[66,167],"shades.":[67],"On":[68],"other":[70],"hand,":[71],"have":[73,141],"more":[74],"regular":[75],"round":[76],"shapes":[78,145],"smaller":[81],"when":[84],"compared":[85],"found":[89],"oligodendroglioma,":[91],"astrocytomas,":[92],"or":[93,152],"oligoastrocytomas.":[94],"The":[95,117,181,230],"first":[96],"task":[97,119],"positive":[103],"regions":[105],"region":[108],"interest":[110],"image":[111],"selected":[112],"from":[113],"whole":[115],"second":[118],"each":[123,155],"nucleus":[125],"count":[127],"number":[129],"nuclei.":[132],"However,":[133],"belonging":[137],"cases":[140],"particularly":[142],"irregular":[143],"form":[147],"clusters":[149,215,221],"by":[150,206,216,246,291,317],"touching":[151],"overlapping":[153],"other.":[156],"addition":[158],"this":[160],"clustered":[161],"structure,":[162],"shading":[164],"stain":[168],"texture":[171],"slightly":[176],"image.":[180,280],"final":[182],"step":[183],"algorithm":[186,284],"classify":[189],"versus":[192],"oligodendrocytes.":[193],"Our":[194],"starts":[196],"color":[198],"segmentation":[199,241,297],"positively":[202],"followed":[205],"classification":[208],"single":[210],"individual":[211,287],"K-means":[217],"clustering.":[218],"Detected":[219],"segmented":[223],"H-minima":[226],"based":[227],"watershed":[228],"algorithm.":[229],"novel":[231],"aspects":[232],"our":[234],"work":[235],"are:":[236],"1)":[237],"detection":[239],"multiple-type,":[243],"positively-stained":[244],"incorporating":[247],"only":[248],"minimal":[249],"prior":[250],"information;":[251],"2)":[253],"adaptively":[254],"determining":[255],"clustering":[256],"parameters":[257],"adjust":[259],"natural":[262],"variation":[263],"staining":[265],"as":[266,268],"well":[267],"underlying":[270],"cellular":[271],"structure":[272],"while":[273],"accommodating":[274],"multiple":[275],"types":[277],"Performance":[281],"evaluated":[290],"sensitivity":[292,300],"precision":[294],"metrics.":[295],"Promising":[296],"results":[298],"(91%":[299],"86%":[302],"precision)":[303],"were":[304],"achieved":[305],"dataset":[308],"fourteen":[310],"slides":[312],"ground":[314],"truth":[315],"markings":[316],"two":[318],"pathologists.":[319]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
