{"id":"https://openalex.org/W2029558139","doi":"https://doi.org/10.1117/12.2077713","title":"Longitudinal graph-based segmentation of macular OCT using fundus alignment","display_name":"Longitudinal graph-based segmentation of macular OCT using fundus alignment","publication_year":2015,"publication_date":"2015-03-20","ids":{"openalex":"https://openalex.org/W2029558139","doi":"https://doi.org/10.1117/12.2077713","mag":"2029558139","pmid":"https://pubmed.ncbi.nlm.nih.gov/26023248"},"language":"en","primary_location":{"id":"doi:10.1117/12.2077713","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2077713","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103480360","display_name":"Andrew Lang","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew Lang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The Johns Hopkins University","Johns\u00a0 Hopkins University, United States"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns\u00a0 Hopkins University, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075622613","display_name":"Aaron Carass","orcid":"https://orcid.org/0000-0003-4939-5085"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Carass","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The Johns Hopkins University ; Department of Computer Science, The Johns Hopkins University","Johns\u00a0 Hopkins University, United States"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Johns Hopkins University ; Department of Computer Science, The Johns Hopkins University","institution_ids":[]},{"raw_affiliation_string":"Johns\u00a0 Hopkins University, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023759929","display_name":"Omar Al\u2010Louzi","orcid":"https://orcid.org/0000-0003-2260-5660"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Al-Louzi","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University School of Medicine","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076230774","display_name":"Pavan Bhargava","orcid":"https://orcid.org/0000-0002-7947-9418"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavan Bhargava","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University School of Medicine","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108447802","display_name":"Howard S. Ying","orcid":null},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard S. Ying","raw_affiliation_strings":["Wilmer Eye Institute, The Johns Hopkins University School of Medicine","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Wilmer Eye Institute, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061851273","display_name":"Peter A. Calabresi","orcid":"https://orcid.org/0000-0002-7776-6472"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Calabresi","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University School of Medicine","Johns Hopkins University School of Medicine, United States"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University School of Medicine","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, United States","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066682675","display_name":"Jerry L. Prince","orcid":"https://orcid.org/0000-0002-6553-0876"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry L. Prince","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The Johns Hopkins University","Johns\u00a0 Hopkins University, United States"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns\u00a0 Hopkins University, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5103480360"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":1.6233,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8283733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9413","issue":null,"first_page":"94130M","last_page":"94130M"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.8217729926109314},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.702089786529541},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6849690675735474},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6253716945648193},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5241796374320984},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5016248226165771},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4879314601421356},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4757882356643677},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.46030691266059875},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.45633596181869507},{"id":"https://openalex.org/keywords/scale-space-segmentation","display_name":"Scale-space segmentation","score":0.43480533361434937},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.09173685312271118},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.07711255550384521}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.8217729926109314},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.702089786529541},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6849690675735474},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6253716945648193},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5241796374320984},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5016248226165771},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4879314601421356},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4757882356643677},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.46030691266059875},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.45633596181869507},{"id":"https://openalex.org/C65885262","wikidata":"https://www.wikidata.org/wiki/Q7429708","display_name":"Scale-space segmentation","level":4,"score":0.43480533361434937},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.09173685312271118},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.07711255550384521},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2077713","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2077713","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:26023248","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26023248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:europepmc.org:3406265","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4443705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"No poverty","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/1"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W73321994","https://openalex.org/W1940014806","https://openalex.org/W1970663794","https://openalex.org/W1973908083","https://openalex.org/W2000511084","https://openalex.org/W2011237852","https://openalex.org/W2038850290","https://openalex.org/W2083181574","https://openalex.org/W2086295185","https://openalex.org/W2100546771","https://openalex.org/W2113137767","https://openalex.org/W2127318120","https://openalex.org/W2128579987","https://openalex.org/W2146112699","https://openalex.org/W2164774194","https://openalex.org/W2332643163","https://openalex.org/W2911964244","https://openalex.org/W4205098750"],"related_works":["https://openalex.org/W2185902295","https://openalex.org/W2103507220","https://openalex.org/W3144569342","https://openalex.org/W2945274617","https://openalex.org/W4313052709","https://openalex.org/W2022929107","https://openalex.org/W2055202857","https://openalex.org/W80586315","https://openalex.org/W4205800335","https://openalex.org/W2758994127"],"abstract_inverted_index":{"Segmentation":[0],"of":[1,18],"retinal":[2,51,103,106],"layers":[3],"in":[4,50,169],"optical":[5],"coherence":[6],"tomography":[7],"(OCT)":[8],"has":[9],"become":[10],"an":[11],"important":[12],"diagnostic":[13],"tool":[14],"for":[15],"a":[16,58,88,110,154],"variety":[17],"ocular":[19],"and":[20,44,105,153],"neurological":[21],"diseases.":[22],"Currently":[23],"all":[24],"OCT":[25],"segmentation":[26,60,66,116,166],"algorithms":[27],"analyze":[28],"data":[29,99,139],"independently,":[30],"ignoring":[31],"previous":[32],"scans,":[33],"which":[34],"can":[35],"lead":[36],"to":[37,41,46,62,87,124,176,179],"spurious":[38],"measurements":[39],"due":[40,178],"algorithm":[42],"variability":[43,147],"failure":[45],"identify":[47],"subtle":[48],"changes":[49],"layers.":[52],"In":[53],"this":[54],"paper,":[55],"we":[56,144],"present":[57],"graph-based":[59],"framework":[61],"provide":[63],"consistent":[64],"longitudinal":[65,138,150,163],"results.":[67],"Regularization":[68],"over":[69],"time":[70],"is":[71,135],"accomplished":[72],"by":[73,96,129],"adding":[74],"weighted":[75],"edges":[76],"between":[77,148],"corresponding":[78],"voxels":[79],"at":[80],"each":[81],"visit.":[82],"We":[83],"align":[84],"the":[85,94,98,102,119,131,146,162,172],"scans":[86],"common":[89],"subject":[90],"space":[91],"before":[92],"connecting":[93],"graphs":[95],"registering":[97],"using":[100],"both":[101],"vasculature":[104],"thickness":[107],"generated":[108],"from":[109,140],"low":[111],"resolution":[112],"segmentation.":[113],"This":[114],"initial":[115],"also":[117],"allows":[118],"higher":[120],"dimensional":[121],"temporal":[122],"problem":[123],"be":[125],"solved":[126],"more":[127],"efficiently":[128],"reducing":[130],"graph":[132,151,156],"size.":[133],"Validation":[134],"performed":[136],"on":[137],"24":[141],"subjects,":[142],"where":[143,171],"explore":[145],"our":[149],"method":[152],"cross-sectional":[155],"approach.":[157],"Our":[158],"results":[159],"demonstrate":[160],"that":[161],"component":[164],"improves":[165],"consistency,":[167],"particularly":[168],"areas":[170],"boundaries":[173],"are":[174],"difficult":[175],"visualize":[177],"poor":[180],"scan":[181],"quality.":[182]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
