{"id":"https://openalex.org/W1969094840","doi":"https://doi.org/10.1117/12.2043737","title":"Mediastinal lymph node detection on thoracic CT scans using spatial prior from multi-atlas label fusion","display_name":"Mediastinal lymph node detection on thoracic CT scans using spatial prior from multi-atlas label fusion","publication_year":2014,"publication_date":"2014-03-18","ids":{"openalex":"https://openalex.org/W1969094840","doi":"https://doi.org/10.1117/12.2043737","mag":"1969094840"},"language":"en","primary_location":{"id":"doi:10.1117/12.2043737","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043737","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107883975","display_name":"Jiamin Liu","orcid":"https://orcid.org/0009-0007-9802-5562"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiamin Liu","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076934697","display_name":"Jocelyn Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jocelyn Zhao","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026506226","display_name":"Joanne Hoffman","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Hoffman","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695406","display_name":"Jianhua Yao","orcid":"https://orcid.org/0000-0001-9157-9596"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Yao","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428725","display_name":"Weidong Zhang","orcid":"https://orcid.org/0000-0001-6829-1033"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weidong Zhang","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058741321","display_name":"Evrim T\u00fcrkbey","orcid":"https://orcid.org/0000-0002-5216-3528"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evrim B. Turkbey","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627213","display_name":"Shijun Wang","orcid":"https://orcid.org/0000-0002-2873-8432"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shijun Wang","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686499","display_name":"Christine Kim","orcid":"https://orcid.org/0000-0002-8762-4291"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Kim","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016047550","display_name":"Ronald M. Summers","orcid":"https://orcid.org/0000-0001-8081-7376"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Summers","raw_affiliation_strings":["National Institutes of Health (United States)","National Institutes of Health, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"National Institutes of Health (United States)","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health, UNITED STATES","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5107883975"],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":2.1201,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.86783196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9035","issue":null,"first_page":"90350M","last_page":"90350M"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.6982205510139465},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5597183108329773},{"id":"https://openalex.org/keywords/lymph","display_name":"Lymph","score":0.5310314893722534},{"id":"https://openalex.org/keywords/lymph-node","display_name":"Lymph node","score":0.5304642915725708},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.4758436679840088},{"id":"https://openalex.org/keywords/mediastinal-lymph-node","display_name":"Mediastinal lymph node","score":0.4553738534450531},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.44396084547042847},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4381800889968872},{"id":"https://openalex.org/keywords/mediastinum","display_name":"Mediastinum","score":0.4152785837650299},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.35577815771102905},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2910745441913605},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15582504868507385}],"concepts":[{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.6982205510139465},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5597183108329773},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5310314893722534},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5304642915725708},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.4758436679840088},{"id":"https://openalex.org/C2780379385","wikidata":"https://www.wikidata.org/wiki/Q1916209","display_name":"Mediastinal lymph node","level":4,"score":0.4553738534450531},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.44396084547042847},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4381800889968872},{"id":"https://openalex.org/C2779126056","wikidata":"https://www.wikidata.org/wiki/Q337247","display_name":"Mediastinum","level":2,"score":0.4152785837650299},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.35577815771102905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2910745441913605},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15582504868507385},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2043737","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043737","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1489669443","https://openalex.org/W1548637692","https://openalex.org/W1600797902","https://openalex.org/W1970928383","https://openalex.org/W2003644909","https://openalex.org/W2018662705","https://openalex.org/W2019607817","https://openalex.org/W2044465660","https://openalex.org/W2049247209","https://openalex.org/W2050901298","https://openalex.org/W2068934234","https://openalex.org/W2106184520","https://openalex.org/W2133537747","https://openalex.org/W2160153825","https://openalex.org/W6629144004","https://openalex.org/W6632753626","https://openalex.org/W6635738081","https://openalex.org/W6679670634"],"related_works":["https://openalex.org/W2411759252","https://openalex.org/W1557094818","https://openalex.org/W2140471736","https://openalex.org/W3027020613","https://openalex.org/W4174475","https://openalex.org/W2123084373","https://openalex.org/W2121910013","https://openalex.org/W2380930958","https://openalex.org/W1994277176","https://openalex.org/W2022977151"],"abstract_inverted_index":{"Lymph":[0],"nodes":[1,115],"play":[2],"an":[3],"important":[4],"role":[5],"in":[6],"clinical":[7],"practice":[8],"but":[9],"detection":[10,34],"is":[11,67,120],"challenging":[12],"due":[13],"to":[14,44,132,160],"low":[15],"contrast":[16],"surrounding":[17],"structures":[18,76],"and":[19,22,56,89,116,124],"variable":[20],"size":[21],"shape.":[23],"We":[24,128],"propose":[25],"a":[26,144,170],"fully":[27],"automatic":[28],"method":[29,131],"for":[30,95,122],"mediastinal":[31,138],"lymph":[32,96,114,139],"node":[33,97],"on":[35,70,111],"thoracic":[36],"CT":[37],"scans.":[38],"First,":[39],"lungs":[40],"are":[41,59,92,102,109],"automatically":[42],"segmented":[43,103,113],"locate":[45],"the":[46,71,112],"mediastinum":[47],"region.":[48],"Shape":[49,87],"features":[50,88,108],"by":[51,82,104],"Hessian":[52],"analysis,":[53],"local":[54],"scale,":[55],"circular":[57],"transformation":[58],"computed":[60],"at":[61,150,163],"each":[62],"voxel.":[63],"Spatial":[64],"prior":[65,91,158],"distribution":[66],"determined":[68],"based":[69],"identification":[72],"of":[73],"multiple":[74],"anatomical":[75],"(esophagus,":[77],"aortic":[78],"arch,":[79],"heart,":[80],"etc.)":[81],"using":[83],"multi-atlas":[84],"label":[85],"fusion.":[86],"spatial":[90,157,171],"then":[93],"integrated":[94],"detection.":[98],"The":[99,141],"detected":[100],"candidates":[101],"curve":[105],"evolution.":[106],"Characteristic":[107],"calculated":[110],"support":[117],"vector":[118],"machine":[119],"utilized":[121],"classification":[123],"false":[125,152,165],"positive":[126],"reduction.":[127],"applied":[129],"our":[130],"20":[133],"patients":[134],"with":[135,147,156],"62":[136],"enlarged":[137],"nodes.":[140],"system":[142],"achieved":[143],"significant":[145],"improvement":[146],"80%":[148],"sensitivity":[149,162],"8":[151,164],"positives":[153,166],"per":[154,167],"patient":[155,168],"compared":[159],"45%":[161],"without":[169],"prior.":[172]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
