{"id":"https://openalex.org/W2086048403","doi":"https://doi.org/10.1117/12.2043716","title":"Accuracy and variability of tumor burden measurement on multi-parametric MRI","display_name":"Accuracy and variability of tumor burden measurement on multi-parametric MRI","publication_year":2014,"publication_date":"2014-03-20","ids":{"openalex":"https://openalex.org/W2086048403","doi":"https://doi.org/10.1117/12.2043716","mag":"2086048403"},"language":"en","primary_location":{"id":"doi:10.1117/12.2043716","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043716","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085276585","display_name":"Mehrnoush Salarian","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Mehrnoush Salarian","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025274219","display_name":"Eli Gibson","orcid":"https://orcid.org/0000-0001-9207-7280"},"institutions":[{"id":"https://openalex.org/I4210105758","display_name":"Robarts Clinical Trials","ror":"https://ror.org/01e36dv41","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4210105758","https://openalex.org/I4405252475"]},{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eli Gibson","raw_affiliation_strings":["Robarts Research Institute (Canada)","The Univ. of Western Ontario (Canada)","Robarts Research Institute  (Canada)"],"affiliations":[{"raw_affiliation_string":"Robarts Research Institute (Canada)","institution_ids":["https://openalex.org/I4210105758"]},{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"Robarts Research Institute  (Canada)","institution_ids":["https://openalex.org/I4210105758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056465640","display_name":"Maysam Shahedi","orcid":"https://orcid.org/0000-0001-9108-2010"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maysam Shahedi","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060699372","display_name":"Mena Gaed","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mena Gaed","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071439377","display_name":"Jos\u00e9 A. G\u00f3mez","orcid":"https://orcid.org/0000-0001-8148-8308"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. G\u00f3mez","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055091318","display_name":"Madeleine Moussa","orcid":"https://orcid.org/0000-0003-4786-6226"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Madeleine Moussa","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046185743","display_name":"Cesare Romagnoli","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cesare Romagnoli","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003730977","display_name":"Derek W. Cool","orcid":"https://orcid.org/0000-0003-1095-3553"},"institutions":[{"id":"https://openalex.org/I4210105758","display_name":"Robarts Clinical Trials","ror":"https://ror.org/01e36dv41","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4210105758","https://openalex.org/I4405252475"]},{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Derek W. Cool","raw_affiliation_strings":["Robarts Research Institute (Canada)","The Univ. of Western Ontario (Canada)"],"affiliations":[{"raw_affiliation_string":"Robarts Research Institute (Canada)","institution_ids":["https://openalex.org/I4210105758"]},{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023336011","display_name":"Matthew Bastian\u2010Jordan","orcid":"https://orcid.org/0000-0003-0825-880X"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew Bastian-Jordan","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046888497","display_name":"Joseph L. Chin","orcid":"https://orcid.org/0000-0002-1171-1436"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joseph L. Chin","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048665338","display_name":"Stephen Pautler","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephen Pautler","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019768466","display_name":"Glenn Bauman","orcid":"https://orcid.org/0000-0002-5279-7360"},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Glenn S. Bauman","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113914224","display_name":"Aaron D. Ward","orcid":null},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aaron D. Ward","raw_affiliation_strings":["The Univ. of Western Ontario (Canada)","The University of Western Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Univ. of Western Ontario (Canada)","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"The University of Western Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5085276585"],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":null,"apc_paid":null,"fwci":0.4711,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69582467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9041","issue":null,"first_page":"90410I","last_page":"90410I"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.6982948780059814},{"id":"https://openalex.org/keywords/prostate","display_name":"Prostate","score":0.6433148384094238},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5832191109657288},{"id":"https://openalex.org/keywords/contouring","display_name":"Contouring","score":0.5554286241531372},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5285215377807617},{"id":"https://openalex.org/keywords/effective-diffusion-coefficient","display_name":"Effective diffusion coefficient","score":0.4663879871368408},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4469423294067383},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43306174874305725},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4218367338180542},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2695766091346741},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07509469985961914}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6982948780059814},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6433148384094238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5832191109657288},{"id":"https://openalex.org/C2779104521","wikidata":"https://www.wikidata.org/wiki/Q23058469","display_name":"Contouring","level":2,"score":0.5554286241531372},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5285215377807617},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.4663879871368408},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4469423294067383},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43306174874305725},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4218367338180542},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2695766091346741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07509469985961914},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2043716","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043716","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1982310921","https://openalex.org/W1987778129","https://openalex.org/W2007359749","https://openalex.org/W2007995537","https://openalex.org/W2014914090","https://openalex.org/W2024729210","https://openalex.org/W2045862330","https://openalex.org/W2058782089","https://openalex.org/W2089127932","https://openalex.org/W2124539070","https://openalex.org/W2135713469","https://openalex.org/W2137270859","https://openalex.org/W2151741113","https://openalex.org/W2168133848","https://openalex.org/W4235491463","https://openalex.org/W6653968237","https://openalex.org/W6679974339"],"related_works":["https://openalex.org/W2028761375","https://openalex.org/W2915337797","https://openalex.org/W2360204191","https://openalex.org/W2968335000","https://openalex.org/W3015759778","https://openalex.org/W2088520467","https://openalex.org/W2075763133","https://openalex.org/W2376423713","https://openalex.org/W1583600832","https://openalex.org/W2811415171"],"abstract_inverted_index":{"Measurement":[0],"of":[1,14,19,31,60,65,74,94,104,146,171,232],"prostate":[2,85,95,156,234],"tumour":[3,47,61,96,148,157,167,172,203,235,245],"volume":[4,48,97,173,187,215,236],"can":[5,23],"inform":[6],"prognosis":[7],"and":[8,17,68,91,110,142,197],"treatment":[9],"selection,":[10],"including":[11],"an":[12,69,117],"assessment":[13],"the":[15,27,37,89,176,193,198,206,213,225,230],"suitability":[16],"feasibility":[18],"focal":[20],"therapy,":[21],"which":[22],"potentially":[24],"spare":[25],"patients":[26],"deleterious":[28],"side":[29],"effects":[30],"radical":[32],"treatment.":[33],"Prostate":[34],"biopsy":[35],"is":[36,81,122],"clinical":[38,66],"standard":[39,133],"for":[40,57,84,244],"diagnosis":[41],"but":[42],"provides":[43],"limited":[44],"information":[45],"regarding":[46],"due":[49],"to":[50],"sparse":[51],"tissue":[52],"sampling.":[53],"A":[54],"non-invasive":[55],"means":[56],"accurate":[58,138],"determination":[59],"burden":[62,246],"could":[63,228],"be":[64],"value":[67],"important":[70],"step":[71],"toward":[72],"reduction":[73],"overtreatment.":[75],"Multi-parametric":[76],"magnetic":[77],"resonance":[78],"imaging":[79],"(MPMRI)":[80],"showing":[82],"promise":[83],"cancer":[86],"diagnosis.":[87],"However,":[88],"accuracy":[90],"inter-observer":[92,195],"variability":[93,170,182,196],"estimation":[98,216,247],"based":[99,134,160],"on":[100,135,150,161,189,220,248],"separate":[101],"expert":[102],"contouring":[103],"T2-weighted":[105],"(T2W),":[106],"dynamic":[107],"contrastenhanced":[108],"(DCE),":[109],"diffusion-weighted":[111],"(DW)":[112],"MRI":[113,191],"sequences":[114,179],"acquired":[115],"using":[116,129],"endorectal":[118],"coil":[119],"at":[120],"3T":[121],"currently":[123],"unknown.":[124],"We":[125],"investigated":[126],"this":[127],"question":[128],"a":[130,136,143,221],"histologic":[131],"reference":[132,166],"highly":[137],"MPMRIhistology":[139],"image":[140],"registration":[141],"smooth":[144],"interpolation":[145],"planimetric":[147],"measurements":[149],"histology.":[151],"Our":[152],"results":[153],"showed":[154],"that":[155],"volumes":[158],"estimated":[159],"MPMRI":[162],"consistently":[163],"overestimated":[164],"histological":[165],"volumes.":[168],"The":[169],"estimates":[174,188],"across":[175],"different":[177],"pulse":[178],"exceeded":[180],"interobserver":[181],"within":[183],"any":[184],"sequence.":[185],"Tumour":[186],"DCE":[190],"provided":[192,212],"lowest":[194,214],"highest":[199],"correlation":[200],"with":[201],"histology":[202],"volumes,":[204],"whereas":[205],"apparent":[207],"diffusion":[208],"coefficient":[209],"(ADC)":[210],"maps":[211],"error.":[217],"If":[218],"validated":[219],"larger":[222],"data":[223],"set,":[224],"observed":[226],"correlations":[227],"support":[229],"development":[231],"automated":[233],"segmentation":[237],"algorithms":[238],"as":[239,241],"well":[240],"correction":[242],"schemes":[243],"MPMRI.":[249]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
