{"id":"https://openalex.org/W2063399427","doi":"https://doi.org/10.1117/12.2043568","title":"Statistical analysis of surrogate signals to incorporate respiratory motion variability into radiotherapy treatment planning","display_name":"Statistical analysis of surrogate signals to incorporate respiratory motion variability into radiotherapy treatment planning","publication_year":2014,"publication_date":"2014-03-12","ids":{"openalex":"https://openalex.org/W2063399427","doi":"https://doi.org/10.1117/12.2043568","mag":"2063399427"},"language":"en","primary_location":{"id":"doi:10.1117/12.2043568","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043568","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051753610","display_name":"Matthias Wilms","orcid":"https://orcid.org/0000-0001-8845-360X"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Wilms","raw_affiliation_strings":["Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","Institute of Medical Informatics, University of Lubeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Informatics, University of Lubeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050326500","display_name":"Jan Ehrhardt","orcid":null},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Ehrhardt","raw_affiliation_strings":["Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","Institute of Medical Informatics, University of Lubeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Informatics, University of Lubeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010196512","display_name":"Ren\u00e9 Werner","orcid":"https://orcid.org/0000-0002-2296-3305"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Werner","raw_affiliation_strings":["Univ. Medical Ctr. Hamburg-Eppendorf (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Medical Ctr. Hamburg-Eppendorf (Germany)","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578135","display_name":"Mirko Marx","orcid":null},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirko Marx","raw_affiliation_strings":["Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","Institute of Medical Informatics, University of Lubeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Informatics, University of Lubeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013972125","display_name":"Heinz Handels","orcid":"https://orcid.org/0000-0002-3499-4328"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz Handels","raw_affiliation_strings":["Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","Institute of Medical Informatics, University of Lubeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Informatics, Univ. of L\u00fcbeck (Germany)","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Informatics, University of Lubeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6896,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.82157926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"9036","issue":null,"first_page":"90360J","last_page":"90360J"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5421938896179199},{"id":"https://openalex.org/keywords/spline","display_name":"Spline (mechanical)","score":0.46337857842445374},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.33653461933135986},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2358260154724121},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16383689641952515}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5421938896179199},{"id":"https://openalex.org/C10390562","wikidata":"https://www.wikidata.org/wiki/Q581809","display_name":"Spline (mechanical)","level":2,"score":0.46337857842445374},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.33653461933135986},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2358260154724121},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16383689641952515},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2043568","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043568","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W27686015","https://openalex.org/W1679114131","https://openalex.org/W1983710525","https://openalex.org/W1984551983","https://openalex.org/W1989027364","https://openalex.org/W2019289784","https://openalex.org/W2031512758","https://openalex.org/W2039125507","https://openalex.org/W2050420015","https://openalex.org/W2052861676","https://openalex.org/W2078438223","https://openalex.org/W2127480863","https://openalex.org/W2128426758","https://openalex.org/W2167767036","https://openalex.org/W2312527436","https://openalex.org/W6646301319"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2350741829","https://openalex.org/W2530322880","https://openalex.org/W1596801655","https://openalex.org/W2359140296"],"abstract_inverted_index":{"Respiratory":[0],"motion":[1,21,128,168],"and":[2,15,45,66,122,131,160,169],"its":[3,170],"variability":[4,171],"lead":[5],"to":[6,124,155,161],"location":[7],"uncertainties":[8],"in":[9,23,151],"radiation":[10],"therapy":[11],"(RT)":[12],"of":[13,48,77,99,116,129,166],"thoracic":[14],"abdominal":[16],"tumors.":[17],"Current":[18],"approaches":[19],"for":[20,41],"compensation":[22],"RT":[24,152],"are":[25,81,92],"usually":[26],"driven":[27],"by":[28,95],"respiratory":[29,167],"surrogate":[30,49,114],"signals,":[31],"e.g.,":[32,63],"spirometry.":[33],"In":[34],"this":[35,146],"contribution,":[36],"we":[37,143],"present":[38],"an":[39,78,141],"approach":[40,147],"statistical":[42,72],"analysis,":[43,73],"modeling":[44],"subsequent":[46],"simulation":[47],"signals":[50,57,115],"on":[51,89,134,172],"a":[52,108,135],"cycle-by-cycle":[53],"basis.":[54],"The":[55],"simulated":[56],"represent":[58],"typical":[59],"patient-specific":[60,136],"variations":[61],"of,":[62],"breathing":[64,75,90],"amplitude":[65],"cycle":[67],"period.":[68],"For":[69],"the":[70,97,100,126,164],"underlying":[71],"all":[74],"cycles":[76,91],"observed":[79],"signal":[80],"consistently":[82],"parameterized":[83],"using":[84,96],"approximating":[85],"B-spline":[86,101],"curves.":[87],"Statistics":[88],"then":[93],"performed":[94],"parameters":[98,106],"approximations.":[102],"Assuming":[103],"that":[104],"these":[105],"follow":[107],"multivariate":[109],"Gaussian":[110],"distribution,":[111],"realistic":[112],"time-continuous":[113],"arbitrary":[117],"length":[118],"can":[119,148],"be":[120,149],"generated":[121],"used":[123],"simulate":[125],"internal":[127],"tumors":[130],"organs":[132],"based":[133],"diffeomorphic":[137],"correspondence":[138],"model.":[139],"As":[140],"example,":[142],"show":[144],"how":[145],"employed":[150],"treatment":[153],"planning":[154],"calculate":[156],"tumor":[157],"appearance":[158],"probabilities":[159],"statistically":[162],"assess":[163],"impact":[165],"planned":[173],"dose":[174],"distributions.":[175]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}