{"id":"https://openalex.org/W2124017050","doi":"https://doi.org/10.1117/12.2043565","title":"On study design in neuroimaging heritability analyses","display_name":"On study design in neuroimaging heritability analyses","publication_year":2014,"publication_date":"2014-03-21","ids":{"openalex":"https://openalex.org/W2124017050","doi":"https://doi.org/10.1117/12.2043565","mag":"2124017050","pmid":"https://pubmed.ncbi.nlm.nih.gov/41799442"},"language":"en","primary_location":{"id":"doi:10.1117/12.2043565","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043565","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12965216/pdf/nihms-2062570.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041687327","display_name":"Mary Ellen Koran","orcid":"https://orcid.org/0000-0002-1669-2668"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ellen Koran","raw_affiliation_strings":["Medical Scientist Training Program, Vanderbilt University, Nashville, TN USA","Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN USA","Vanderbilt Univ (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Scientist Training Program, Vanderbilt University, Nashville, TN USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604093","display_name":"Bo Li","orcid":"https://orcid.org/0000-0002-2676-926X"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Li","raw_affiliation_strings":["Electrical Engineering, Vanderbilt University, Nashville, TN USA","Vanderbilt Univ (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering, Vanderbilt University, Nashville, TN USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781190","display_name":"Neda Jahanshad","orcid":"https://orcid.org/0000-0003-4401-8950"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jahanshad","raw_affiliation_strings":["Neurology, University of California Los Angeles, Los Angeles, CA USA","University of California Los Angeles UNITED STATES"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, University of California Los Angeles, Los Angeles, CA USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"University of California Los Angeles UNITED STATES","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033855899","display_name":"Tricia A. Thornton\u2010Wells","orcid":"https://orcid.org/0000-0002-5467-2270"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tricia A. Thornton-Wells","raw_affiliation_strings":["Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN USA","Vanderbilt Univ (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ (United States)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074299304","display_name":"David C. Glahn","orcid":"https://orcid.org/0000-0002-4749-6977"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Glahn","raw_affiliation_strings":["Psychiatry, Yale University, New Haven, CT USA","[Yale University, United States]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry, Yale University, New Haven, CT USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"[Yale University, United States]","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Neurology, University of California Los Angeles, Los Angeles, CA USA","University of California Los Angeles UNITED STATES"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, University of California Los Angeles, Los Angeles, CA USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"University of California Los Angeles UNITED STATES","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004538115","display_name":"John Blangero","orcid":"https://orcid.org/0000-0001-6250-5723"},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Blangero","raw_affiliation_strings":["Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX USA","Texas Biomedical Research Institute, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX USA","institution_ids":["https://openalex.org/I1289525096"]},{"raw_affiliation_string":"Texas Biomedical Research Institute, United States","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056453682","display_name":"Thomas E. Nichols","orcid":"https://orcid.org/0000-0002-4516-5103"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas E. Nichols","raw_affiliation_strings":["Statistics, University of Warwick, Coventry, UK","The University of Warwick, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"The University of Warwick, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022342401","display_name":"Peter Kochunov","orcid":"https://orcid.org/0000-0003-3656-4281"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I2802913063","display_name":"Psychiatric Rehabilitation Association","ror":"https://ror.org/04f1s4r56","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802913063"]},{"id":"https://openalex.org/I6059380","display_name":"University of Baltimore","ror":"https://ror.org/024gw2733","country_code":"US","type":"education","lineage":["https://openalex.org/I6059380"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kochunov","raw_affiliation_strings":["Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD USA","Maryland Psychiatric Research Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I6059380"]},{"raw_affiliation_string":"Maryland Psychiatric Research Ctr. (United States)","institution_ids":["https://openalex.org/I2802913063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075735203","display_name":"Bennett A. Landman","orcid":"https://orcid.org/0000-0001-5733-2127"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett A. Landman","raw_affiliation_strings":["Electrical Engineering, Vanderbilt University, Nashville, TN USA","Vanderbilt Univ (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering, Vanderbilt University, Nashville, TN USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Univ (United States)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13950686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9034","issue":null,"first_page":"90342P","last_page":"90342P"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.8731330633163452},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7691670656204224},{"id":"https://openalex.org/keywords/imaging-genetics","display_name":"Imaging genetics","score":0.6570436954498291},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.6368971467018127},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.6165704131126404},{"id":"https://openalex.org/keywords/quantitative-genetics","display_name":"Quantitative genetics","score":0.5724165439605713},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.5337814688682556},{"id":"https://openalex.org/keywords/missing-heritability-problem","display_name":"Missing heritability problem","score":0.5049548745155334},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4743206202983856},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"Genetic correlation","score":0.4188322424888611},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3976494073867798},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"Genetic variation","score":0.3867349624633789},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3831946849822998},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.3758290410041809},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3358282446861267},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.1956467628479004},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1306513249874115},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.12450295686721802},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07461798191070557}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.8731330633163452},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7691670656204224},{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.6570436954498291},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.6368971467018127},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6165704131126404},{"id":"https://openalex.org/C51255272","wikidata":"https://www.wikidata.org/wiki/Q550479","display_name":"Quantitative genetics","level":4,"score":0.5724165439605713},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.5337814688682556},{"id":"https://openalex.org/C144621757","wikidata":"https://www.wikidata.org/wiki/Q3083720","display_name":"Missing heritability problem","level":5,"score":0.5049548745155334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4743206202983856},{"id":"https://openalex.org/C70616004","wikidata":"https://www.wikidata.org/wiki/Q5532885","display_name":"Genetic correlation","level":4,"score":0.4188322424888611},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3976494073867798},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3867349624633789},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3831946849822998},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3758290410041809},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3358282446861267},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.1956467628479004},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1306513249874115},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12450295686721802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07461798191070557},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2043565","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043565","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:41799442","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41799442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12965216","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12965216/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12965216/pdf/nihms-2062570.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12965216","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12965216/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12965216/pdf/nihms-2062570.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G1037583909","display_name":null,"funder_award_id":"R01 EB015611-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2540626194","display_name":null,"funder_award_id":"U54MH091657","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3676414382","display_name":null,"funder_award_id":"R01 HD050735","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4577735441","display_name":null,"funder_award_id":"T32 GM07347","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5544719773","display_name":null,"funder_award_id":"EB008281","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6169359773","display_name":null,"funder_award_id":"HD050735","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6510794463","display_name":null,"funder_award_id":"EB008432","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G692459944","display_name":null,"funder_award_id":"R01 EB015611","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7248232622","display_name":null,"funder_award_id":"EB007813","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7624910358","display_name":null,"funder_award_id":"GM07347","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124017050.pdf","grobid_xml":"https://content.openalex.org/works/W2124017050.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1966009787","https://openalex.org/W1978124765","https://openalex.org/W2012508139","https://openalex.org/W2015844309","https://openalex.org/W2040769201","https://openalex.org/W2042410266","https://openalex.org/W2077223718","https://openalex.org/W2091682971","https://openalex.org/W2118347577","https://openalex.org/W2156059881"],"related_works":["https://openalex.org/W2099211155","https://openalex.org/W2188017711","https://openalex.org/W1984915072","https://openalex.org/W2924960962","https://openalex.org/W1633080376","https://openalex.org/W2092723268","https://openalex.org/W159064268","https://openalex.org/W2549342335","https://openalex.org/W2026931617","https://openalex.org/W3176395874"],"abstract_inverted_index":{"Imaging":[0],"genetics":[1,60,98],"is":[2,101,146],"an":[3],"emerging":[4],"methodology":[5],"that":[6],"combines":[7],"genetic":[8,16,30,55,83,105,126,159,191],"information":[9],"with":[10,53,107,272],"imaging-derived":[11],"metrics":[12],"to":[13,48,64,81,131,169,190,227],"understand":[14],"how":[15],"factors":[17],"impact":[18],"observable":[19],"structural,":[20],"functional,":[21],"and":[22,51,59,85,113,135,207,248,262,269],"quantitative":[23,87,110],"phenotypes.":[24,163],"Many":[25],"of":[26,43,67,103,116,125,140,151,184,195,214,225,251,259],"the":[27,123,138,144,157,205,215,223,246,249],"most":[28],"well-known":[29],"studies":[31],"are":[32,93,198,218],"based":[33,232],"on":[34,156,233],"Genome-Wide":[35],"Association":[36],"Studies":[37],"(GWAS),":[38],"which":[39,100],"use":[40],"large":[41],"populations":[42],"related":[44,129],"or":[45,142],"unrelated":[46],"individuals":[47],"associate":[49],"traits":[50,73],"disorders":[52],"individual":[54],"factors.":[56],"Merging":[57],"imaging":[58,72,97,234],"may":[61,74],"potentially":[62],"lead":[63],"improved":[65],"power":[66],"association":[68],"in":[69,242],"GWAS":[70],"because":[71],"be":[75,170,178,188],"more":[76],"sensitive":[77],"phenotypes,":[78],"being":[79],"closer":[80],"underlying":[82],"mechanisms,":[84],"their":[86],"nature":[88],"inherently":[89],"increases":[90],"power.":[91],"We":[92,244],"developing":[94],"SOLAR-ECLIPSE":[95],"(SE)":[96],"software":[99],"capable":[102],"performing":[104],"analyses":[106],"both":[108],"large-scale":[109],"trait":[111,168],"data":[112,235],"family":[114,196],"structures":[115,197],"variable":[117],"complexity.":[118],"This":[119,148],"program":[120],"can":[121],"estimate":[122,229],"contribution":[124],"commonality":[127],"among":[128],"subjects":[130],"a":[132,167,171,212,257],"given":[133],"phenotype,":[134],"essentially":[136],"answer":[137],"question":[139],"whether":[141],"not":[143],"phenotype":[145,173],"<i>heritable</i>.":[147],"central":[149],"factor":[150],"interest,":[152],"<i>heritability</i>,":[153],"offers":[154],"bounds":[155],"direct":[158],"influence":[160],"over":[161],"observed":[162],"In":[164],"order":[165],"for":[166,174,201,209],"good":[172],"GWAS,":[175],"it":[176],"must":[177,187],"heritable:":[179],"at":[180],"least":[181],"some":[182],"proportion":[183],"its":[185],"variance":[186],"due":[189],"influences.":[192],"A":[193],"variety":[194],"commonly":[199],"used":[200],"estimating":[202],"heritability,":[203],"yet":[204],"variability":[206,250],"biases":[208],"each":[210],"as":[211,256],"function":[213,258],"sample":[216,260],"size":[217,261],"unknown.":[219],"Herein,":[220],"we":[221],"investigate":[222],"ability":[224],"SOLAR":[226,255],"accurately":[228],"heritability":[230,252],"models":[231],"simulated":[236],"using":[237],"Monte":[238],"Carlo":[239],"methods":[240],"implemented":[241],"R.":[243],"characterize":[245],"bias":[247],"estimates":[253],"from":[254],"pedigree":[263],"structure":[264],"(including":[265],"twins,":[266],"nuclear":[267,270],"families,":[268],"families":[271],"grandparents).":[273]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
