{"id":"https://openalex.org/W2076092288","doi":"https://doi.org/10.1117/12.2043381","title":"Zooming in: high resolution 3D reconstruction of differently stained histological whole slide images","display_name":"Zooming in: high resolution 3D reconstruction of differently stained histological whole slide images","publication_year":2014,"publication_date":"2014-03-20","ids":{"openalex":"https://openalex.org/W2076092288","doi":"https://doi.org/10.1117/12.2043381","mag":"2076092288"},"language":"en","primary_location":{"id":"doi:10.1117/12.2043381","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043381","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101970063","display_name":"Johannes Lotz","orcid":"https://orcid.org/0000-0003-3387-2596"},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johannes Lotz","raw_affiliation_strings":["Fraunhofer MEVIS (Germany)"],"affiliations":[{"raw_affiliation_string":"Fraunhofer MEVIS (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028710782","display_name":"Judith Berger","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Judith Berger","raw_affiliation_strings":["Fraunhofer MEVIS (Germany)"],"affiliations":[{"raw_affiliation_string":"Fraunhofer MEVIS (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102257362","display_name":"Benedikt M\u00fcller","orcid":null},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benedikt M\u00fcller","raw_affiliation_strings":["Universit\u00e4tsKlinikum Heidelberg (Germany)","Universit\u00e4tsklinikum Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsKlinikum Heidelberg (Germany)","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Universit\u00e4tsklinikum Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035914022","display_name":"Kai Breuhahn","orcid":"https://orcid.org/0000-0002-2462-1229"},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kai Breuhahn","raw_affiliation_strings":["Universit\u00e4tsKlinikum Heidelberg (Germany)","Universit\u00e4tsklinikum Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsKlinikum Heidelberg (Germany)","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Universit\u00e4tsklinikum Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039930487","display_name":"Niels Grabe","orcid":"https://orcid.org/0000-0003-1732-3706"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niels Grabe","raw_affiliation_strings":["Ruprecht-Karls-Univ. Heidelberg (Germany)","Ruprecht-Karls-Univ, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Ruprecht-Karls-Univ. Heidelberg (Germany)","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Ruprecht-Karls-Univ, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001706294","display_name":"Stefan Heldmann","orcid":"https://orcid.org/0000-0002-9206-2086"},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Heldmann","raw_affiliation_strings":["Fraunhofer MEVIS (Germany)"],"affiliations":[{"raw_affiliation_string":"Fraunhofer MEVIS (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033981831","display_name":"Andr\u00e9 Homeyer","orcid":"https://orcid.org/0000-0002-9910-7136"},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Homeyer","raw_affiliation_strings":["Fraunhofer MEVIS (Germany)"],"affiliations":[{"raw_affiliation_string":"Fraunhofer MEVIS (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002951798","display_name":"Bernd Lahrmann","orcid":null},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Lahrmann","raw_affiliation_strings":["Ruprecht-Karls-Univ. Heidelberg (Germany)","Universit\u00e4tsKlinikum Heidelberg (Germany)"],"affiliations":[{"raw_affiliation_string":"Ruprecht-Karls-Univ. Heidelberg (Germany)","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Universit\u00e4tsKlinikum Heidelberg (Germany)","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013297753","display_name":"Hendrik Laue","orcid":"https://orcid.org/0000-0003-4271-3861"},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hendrik Laue","raw_affiliation_strings":["Fraunhofer MEVIS (Germany)"],"affiliations":[{"raw_affiliation_string":"Fraunhofer MEVIS (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080509365","display_name":"Janine Olesch","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janine Olesch","raw_affiliation_strings":["Fraunhofer MEVIS (Germany)"],"affiliations":[{"raw_affiliation_string":"Fraunhofer MEVIS (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038307749","display_name":"Michael Schwier","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schwier","raw_affiliation_strings":["Fraunhofer MEVIS (Germany)"],"affiliations":[{"raw_affiliation_string":"Fraunhofer MEVIS (Germany)","institution_ids":["https://openalex.org/I4210137873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001877436","display_name":"Oliver Sedlaczek","orcid":"https://orcid.org/0000-0002-8709-5481"},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Sedlaczek","raw_affiliation_strings":["Universit\u00e4tsKlinikum Heidelberg (Germany)","Universit\u00e4tsklinikum Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsKlinikum Heidelberg (Germany)","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Universit\u00e4tsklinikum Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109226131","display_name":"Arne Warth","orcid":null},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arne Warth","raw_affiliation_strings":["Universit\u00e4tsKlinikum Heidelberg (Germany)","Universit\u00e4tsklinikum Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsKlinikum Heidelberg (Germany)","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Universit\u00e4tsklinikum Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5101970063"],"corresponding_institution_ids":["https://openalex.org/I4210137873"],"apc_list":null,"apc_paid":null,"fwci":3.272,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.92955039,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9041","issue":null,"first_page":"904104","last_page":"904104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7817866802215576},{"id":"https://openalex.org/keywords/zoom","display_name":"Zoom","score":0.6572247743606567},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5843888521194458},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5364784598350525},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"Digital pathology","score":0.5069039463996887},{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.4741653501987457},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4221605360507965},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2163502275943756},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.1432776153087616},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11437371373176575}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7817866802215576},{"id":"https://openalex.org/C124913957","wikidata":"https://www.wikidata.org/wiki/Q1232548","display_name":"Zoom","level":3,"score":0.6572247743606567},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5843888521194458},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5364784598350525},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.5069039463996887},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.4741653501987457},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4221605360507965},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2163502275943756},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.1432776153087616},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11437371373176575},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2043381","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043381","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/384069","is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/384069","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W56656279","https://openalex.org/W658973529","https://openalex.org/W1524894299","https://openalex.org/W1602429356","https://openalex.org/W1969013163","https://openalex.org/W1987869189","https://openalex.org/W2018052077","https://openalex.org/W2060248796","https://openalex.org/W2077306965","https://openalex.org/W2078237160","https://openalex.org/W2121075186","https://openalex.org/W2160754664","https://openalex.org/W2169435361","https://openalex.org/W2418982272","https://openalex.org/W4253680483","https://openalex.org/W6636026523"],"related_works":["https://openalex.org/W2788595494","https://openalex.org/W2244676099","https://openalex.org/W3172556642","https://openalex.org/W3157456843","https://openalex.org/W1990150827","https://openalex.org/W2036676347","https://openalex.org/W2091972240","https://openalex.org/W1589307369","https://openalex.org/W2111943219","https://openalex.org/W2321069309"],"abstract_inverted_index":{"Much":[0],"insight":[1],"into":[2],"metabolic":[3],"interactions,":[4],"tissue":[5,8,35,108,235,259],"growth,":[6],"and":[7,30,67,180,233,261],"organization":[9],"can":[10],"be":[11,76],"gained":[12],"by":[13,162,241],"analyzing":[14],"differently":[15,178],"stained":[16,179,204],"histological":[17],"serial":[18,191],"sections.":[19],"One":[20],"opportunity":[21],"unavailable":[22],"to":[23,43,70,75,80,130,155,188,224,253],"classic":[24],"histology":[25],"is":[26,41,51,153,175,239,251],"three-dimensional":[27],"(3D)":[28],"examination":[29],"computer":[31],"aided":[32],"analysis":[33,88],"of":[34,89,118,144,165,195,216,231,265],"samples.":[36],"In":[37,93,200],"this":[38,94],"case,":[39],"registration":[40,101,152],"needed":[42],"reestablish":[44],"spatial":[45],"correspondence":[46],"between":[47],"adjacent":[48],"slides":[49,124,146],"that":[50],"lost":[52],"during":[53],"the":[54,58,71,82,87,145,163,166,220,225,263],"sectioning":[55,59],"process.":[56],"Furthermore,":[57],"introduces":[60],"various":[61],"distortions":[62],"like":[63],"cuts,":[64],"folding,":[65],"tearing,":[66],"local":[68],"deformations":[69,257],"tissue,":[72],"which":[73],"need":[74],"corrected":[77],"in":[78,258],"order":[79],"exploit":[81],"additional":[83],"information":[84],"arising":[85],"from":[86],"neighboring":[90],"slide":[91],"images.":[92],"paper":[95],"we":[96],"present":[97],"a":[98,106,111,115,135,140,149,196,242],"novel":[99],"image":[100,247],"based":[102],"method":[103,174,187,250],"for":[104,177],"reconstructing":[105],"3D":[107],"block":[109,222],"implementing":[110],"zooming":[112],"strategy":[113],"around":[114],"user-defined":[116],"point":[117],"interest.":[119],"We":[120,133,184],"efficiently":[121],"align":[122],"consecutive":[123],"at":[125],"increasingly":[126],"fine":[127],"resolution":[128],"up":[129],"cell":[131],"level.":[132],"use":[134],"two-step":[136],"approach,":[137],"where":[138],"after":[139],"macroscopic,":[141],"coarse":[142],"alignment":[143,230],"as":[147],"preprocessing,":[148],"nonlinear,":[150],"elastic":[151],"performed":[154],"correct":[156,254],"local,":[157],"non-uniform":[158],"deformations.":[159],"Being":[160],"driven":[161],"optimization":[164],"normalized":[167],"gradient":[168],"field":[169],"(NGF)":[170],"distance":[171],"measure,":[172],"our":[173,186,249],"suitable":[176],"thus":[181],"multi-modal":[182],"slides.":[183],"applied":[185],"ultra":[189],"thin":[190],"sections":[192],"(2":[193],"μm)":[194],"human":[197],"lung":[198],"tumor.":[199],"total":[201],"170":[202],"slides,":[203],"alternately":[205],"with":[206],"four":[207],"different":[208],"stains,":[209],"have":[210],"been":[211],"registered.":[212],"Thorough":[213],"visual":[214],"inspection":[215],"virtual":[217],"cuts":[218],"through":[219],"reconstructed":[221],"perpendicular":[223],"cutting":[226],"plane":[227],"shows":[228],"accurate":[229],"vessels":[232],"other":[234],"structures.":[236],"This":[237],"observation":[238],"confirmed":[240],"quantitative":[243],"analysis.":[244],"Using":[245],"nonlinear":[246],"registration,":[248],"able":[252],"locally":[255],"varying":[256],"structures":[260],"exceeds":[262],"limitations":[264],"globally":[266],"linear":[267],"transformations.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}