{"id":"https://openalex.org/W2056070802","doi":"https://doi.org/10.1117/12.2007735","title":"Computer-aided diagnosis of acute ischemic stroke based on cerebral hypoperfusion using 4D CT angiography","display_name":"Computer-aided diagnosis of acute ischemic stroke based on cerebral hypoperfusion using 4D CT angiography","publication_year":2013,"publication_date":"2013-02-28","ids":{"openalex":"https://openalex.org/W2056070802","doi":"https://doi.org/10.1117/12.2007735","mag":"2056070802"},"language":"en","primary_location":{"id":"doi:10.1117/12.2007735","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2007735","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110933278","display_name":"Jean\u2010Paul Charbonnier","orcid":null},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jean-Paul Charbonnier","raw_affiliation_strings":["Univ. Medical Ctr. Utrecht (Netherlands)","Univ. Medical Ctr., Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Univ. Medical Ctr., Utrecht (Netherlands)","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060168177","display_name":"Ewoud J. Smit","orcid":"https://orcid.org/0000-0002-7090-2742"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ewoud J. Smit","raw_affiliation_strings":["Univ. Medical Ctr. Utrecht (Netherlands)","Univ. Medical Ctr., Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Univ. Medical Ctr., Utrecht (Netherlands)","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033933581","display_name":"Max A. Viergever","orcid":"https://orcid.org/0000-0003-2582-042X"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Max A. Viergever","raw_affiliation_strings":["Univ. Medical Ctr. Utrecht (Netherlands)","Univ. Medical Ctr., Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Univ. Medical Ctr., Utrecht (Netherlands)","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069986738","display_name":"Birgitta K. Velthuis","orcid":"https://orcid.org/0000-0002-2542-9474"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Birgitta K. Velthuis","raw_affiliation_strings":["Univ. Medical Ctr. Utrecht (Netherlands)","Univ. Medical Ctr., Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Univ. Medical Ctr., Utrecht (Netherlands)","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108369061","display_name":"Pieter C. Vos","orcid":"https://orcid.org/0000-0002-9376-2340"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pieter C. Vos","raw_affiliation_strings":["Univ. Medical Ctr. Utrecht (Netherlands)","Univ. Medical Ctr., Utrecht (Netherlands)"],"affiliations":[{"raw_affiliation_string":"Univ. Medical Ctr. Utrecht (Netherlands)","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Univ. Medical Ctr., Utrecht (Netherlands)","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5110933278"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"],"apc_list":null,"apc_paid":null,"fwci":0.3988,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66637619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8670","issue":null,"first_page":"867012","last_page":"867012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9854999780654907,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.6616255044937134},{"id":"https://openalex.org/keywords/angiography","display_name":"Angiography","score":0.5662787556648254},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5272323489189148},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4985077381134033},{"id":"https://openalex.org/keywords/computer-aided-diagnosis","display_name":"Computer-aided diagnosis","score":0.4851892590522766},{"id":"https://openalex.org/keywords/computed-tomography-angiography","display_name":"Computed tomography angiography","score":0.46216464042663574},{"id":"https://openalex.org/keywords/grading","display_name":"Grading (engineering)","score":0.4355666935443878},{"id":"https://openalex.org/keywords/cad","display_name":"CAD","score":0.43371185660362244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4242812991142273},{"id":"https://openalex.org/keywords/perfusion-scanning","display_name":"Perfusion scanning","score":0.4159848392009735},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3459728956222534},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.33485302329063416},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.24324250221252441}],"concepts":[{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6616255044937134},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.5662787556648254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5272323489189148},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4985077381134033},{"id":"https://openalex.org/C2779549770","wikidata":"https://www.wikidata.org/wiki/Q1122413","display_name":"Computer-aided diagnosis","level":2,"score":0.4851892590522766},{"id":"https://openalex.org/C2781347138","wikidata":"https://www.wikidata.org/wiki/Q1024492","display_name":"Computed tomography angiography","level":3,"score":0.46216464042663574},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.4355666935443878},{"id":"https://openalex.org/C194789388","wikidata":"https://www.wikidata.org/wiki/Q17855283","display_name":"CAD","level":2,"score":0.43371185660362244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4242812991142273},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.4159848392009735},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3459728956222534},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.33485302329063416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24324250221252441},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C199639397","wikidata":"https://www.wikidata.org/wiki/Q1788588","display_name":"Engineering drawing","level":1,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2007735","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2007735","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.6700000166893005}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1589419489","https://openalex.org/W4229543669","https://openalex.org/W1783185948","https://openalex.org/W1554029525","https://openalex.org/W2999505641","https://openalex.org/W2401866201","https://openalex.org/W2945629533","https://openalex.org/W615772105","https://openalex.org/W1978794434","https://openalex.org/W2013631688"],"abstract_inverted_index":{"The":[0,131,223,236],"presence":[1],"of":[2,13,38,48,76,91,99,107,121,145,178,194,206,213,221],"collateral":[3,39,77],"blood":[4,21,32,40,78,146],"flow":[5,22],"is":[6,23,42,104,169,187,229],"found":[7],"to":[8,29,33,74,161,171,189,231,244],"be":[9],"a":[10,49,81,85,100,114,162,176,211],"strong":[11],"predictor":[12],"patient":[14,92,110,180,234],"outcome":[15],"after":[16],"acute":[17,245],"ischemic":[18,34,246],"stroke.":[19],"Collateral":[20],"defined":[24],"as":[25],"an":[26,216,241],"alternative":[27],"way":[28],"provide":[30],"oxygenated":[31],"cerebral":[35,122],"tissue.":[36],"Assessment":[37],"supply":[41,79],"currently":[43],"performed":[44,170],"by":[45,197],"visual":[46],"inspection":[47],"Computed":[50],"Tomography":[51],"Angiogram":[52],"(CTA)":[53],"which":[54,83],"introduces":[55],"inter-observer":[56],"variability":[57],"and":[58,149,159,249],"depends":[59],"on":[60,88,142],"the":[61,67,89,97,191,195,219,227],"grading":[62],"scale.":[63],"Furthermore,":[64],"variations":[65],"in":[66,80,124],"arterial":[68],"contrast":[69],"arrival":[70],"time":[71],"may":[72],"lead":[73],"underestimation":[75],"CTA":[82,129],"exerts":[84],"negative":[86],"influence":[87],"prediction":[90],"outcome.":[93,111,181,235],"In":[94],"this":[95],"study,":[96],"feasibility":[98],"Computer-aided":[101],"Diagnosis":[102],"system":[103],"investigated":[105],"capable":[106],"objectively":[108,232],"predicting":[109],"We":[112],"present":[113],"novel":[115],"automatic":[116],"method":[117],"for":[118],"quantitative":[119],"assessment":[120],"hypoperfusion":[123],"timing-invariant":[125],"(i.e.":[126],"delay":[127],"insensitive)":[128],"(TI-CTA).":[130],"proposed":[132],"Vessel":[133],"Density":[134],"Symmetry":[135],"algorithm":[136],"automatically":[137],"generates":[138],"descriptive":[139,157],"maps":[140,158],"based":[141,151],"hemispheric":[143],"asymmetry":[144],"vessels.":[147],"Intensity":[148],"symmetry":[150],"features":[152,174],"are":[153],"extracted":[154],"from":[155],"these":[156],"subjected":[160],"best-first-search":[163],"feature":[164],"selection.":[165],"Linear":[166],"Discriminant":[167],"Analysis":[168],"combine":[172],"selected":[173],"into":[175],"likelihood":[177],"good":[179],"Receiver":[182],"operating":[183],"characteristic":[184],"(ROC)":[185],"analysis":[186],"conducted":[188],"evaluate":[190],"diagnostic":[192],"performance":[193],"CAD":[196,228,238],"leave-one-":[198],"patient-out":[199],"cross":[200],"validation.":[201],"A":[202],"Positive":[203],"Predicting":[204],"Value":[205],"1":[207],"was":[208],"obtained":[209],"at":[210],"sensitivity":[212],"25%":[214],"with":[215],"area":[217],"under":[218],"ROC-curve":[220],"0.86.":[222],"results":[224],"show":[225],"that":[226],"feasible":[230],"predict":[233],"presented":[237],"could":[239],"make":[240],"important":[242],"contribution":[243],"stroke":[247],"diagnosis":[248],"treatment.":[250]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}