{"id":"https://openalex.org/W1979111032","doi":"https://doi.org/10.1117/12.2007699","title":"Survival time prediction of patients with glioblastoma multiforme tumors using spatial distance measurement","display_name":"Survival time prediction of patients with glioblastoma multiforme tumors using spatial distance measurement","publication_year":2013,"publication_date":"2013-02-28","ids":{"openalex":"https://openalex.org/W1979111032","doi":"https://doi.org/10.1117/12.2007699","mag":"1979111032"},"language":"en","primary_location":{"id":"doi:10.1117/12.2007699","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2007699","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102944058","display_name":"Mu Zhou","orcid":"https://orcid.org/0000-0001-5072-5630"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mu Zhou","raw_affiliation_strings":["Univ. of South Florida (United States)","University of South Florida, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"Univ. of South Florida (United States)","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"University of South Florida, UNITED STATES","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000168449","display_name":"Lawrence Hall","orcid":"https://orcid.org/0000-0002-7898-8456"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence O. Hall","raw_affiliation_strings":["Univ. of South Florida (United States)","University of South Florida, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"Univ. of South Florida (United States)","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"University of South Florida, UNITED STATES","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053211631","display_name":"Dmitry B. Goldgof","orcid":"https://orcid.org/0000-0001-5461-863X"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry B. Goldgof","raw_affiliation_strings":["Univ. of South Florida (United States)","University of South Florida, UNITED STATES"],"affiliations":[{"raw_affiliation_string":"Univ. of South Florida (United States)","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"University of South Florida, UNITED STATES","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082346230","display_name":"Robert J. Gillies","orcid":"https://orcid.org/0000-0002-8888-7747"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Gillies","raw_affiliation_strings":["H. Lee Moffitt Cancer Ctr. & Research Institute (United States)"],"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Ctr. & Research Institute (United States)","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032533490","display_name":"Robert A. Gatenby","orcid":"https://orcid.org/0000-0002-1621-1510"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Gatenby","raw_affiliation_strings":["H. Lee Moffitt Cancer Ctr. & Research Institute (United States)"],"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Ctr. & Research Institute (United States)","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102944058"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":2.3233,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86950674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8670","issue":null,"first_page":"86702O","last_page":"86702O"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9552000164985657,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9552000164985657,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9415000081062317,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.9144546985626221},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4827703535556793},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3384048044681549},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.16125896573066711}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.9144546985626221},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4827703535556793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3384048044681549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16125896573066711}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2007699","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2007699","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Regional":[0],"variations":[1,23,49],"in":[2,11,24,50,104],"tumor":[3,25,51,97,110,128,169],"blood":[4],"flow":[5],"and":[6,74,134,152,162,209],"necrosis":[7],"are":[8],"commonly":[9],"observed":[10],"cross":[12],"sectional":[13],"imaging":[14],"of":[15,69,183,190],"clinical":[16],"cancers.":[17],"We":[18,166],"hypothesize":[19],"that":[20,34,168],"radiologically-defined":[21,90],"regional":[22],"characteristics":[26],"can":[27,176],"be":[28,177],"used":[29,178],"to":[30,46,86,204],"define":[31],"distinct":[32],"\u201chabitats\u201d":[33],"reflect":[35],"the":[36,138,149,160],"underlying":[37],"evolutionary":[38],"dynamics.":[39],"Here":[40],"we":[41],"present":[42],"an":[43,132,187],"experimental":[44],"framework":[45],"extract":[47],"spatially-explicit":[48],"features":[52],"(habitats)":[53],"from":[54,77],"multiple":[55],"MRI":[56,66,107],"sequences":[57,67],"performed":[58,113],"on":[59,100,119,159],"patients":[60],"with":[61,206],"Glioblastoma":[62],"Multiforme":[63],"(GBM).":[64],"The":[65,78,126],"consist":[68],"post":[70,122],"gadolinium":[71],"T1-weighted,":[72],"FLAIR,":[73],"T2-weighted":[75,153],"images":[76,164],"Cancer":[79],"Genome":[80],"Atlas":[81],"(TCGA).":[82],"Our":[83],"strategy":[84],"is":[85],"identify":[87],"spatially":[88],"distinct,":[89],"intratumoral":[91],"habitats":[92],"by":[93,114,137,143],"characterizing":[94],"each":[95],"small":[96],"regions":[98],"based":[99],"their":[101],"combined":[102],"properties":[103],"3":[105],"different":[106],"sequences.":[108],"Initial":[109],"identification":[111],"was":[112,129,157],"manually":[115],"drawing":[116],"a":[117,120,144,180],"mask":[118,145],"T1-weighted":[121],"contrast":[123],"image":[124],"slice.":[125],"extracted":[127],"segmented":[130],"into":[131],"enhancing":[133],"non-enhancing":[135],"region":[136],"Otsu":[139,156],"segmentation":[140],"algorithm,":[141],"followed":[142],"mapping":[146],"procedure":[147],"onto":[148],"corresponding":[150],"FLAIR":[151,161],"images.":[154],"Then":[155],"applied":[158],"T2":[163],"separately.":[165],"find":[167],"heterogeneity":[170],"measured":[171],"through":[172],"Distance":[173],"Features":[174],"(DF)":[175],"as":[179],"strong":[181],"predictor":[182],"survival":[184,211],"time.":[185],"In":[186],"initial":[188],"cohort":[189],"16":[191],"cases":[192],"slow":[193],"progressing":[194],"tumors":[195],"have":[196],"lower":[197],"DF":[198],"values":[199],"(are":[200],"less":[201],"heterogeneous)":[202],"compared":[203],"those":[205],"fast":[207],"progression":[208],"short":[210],"times.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}