{"id":"https://openalex.org/W1993684203","doi":"https://doi.org/10.1117/12.2007036","title":"pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer","display_name":"pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer","publication_year":2013,"publication_date":"2013-03-13","ids":{"openalex":"https://openalex.org/W1993684203","doi":"https://doi.org/10.1117/12.2007036","mag":"1993684203"},"language":"en","primary_location":{"id":"doi:10.1117/12.2007036","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2007036","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014599500","display_name":"Monica Enescu","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Monica Enescu","raw_affiliation_strings":["Univ. of Oxford (United Kingdom)","University of Oxford,  United Kingdom"],"affiliations":[{"raw_affiliation_string":"Univ. of Oxford (United Kingdom)","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"University of Oxford,  United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088455688","display_name":"Manav Bhushan","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Manav Bhushan","raw_affiliation_strings":["Univ. of Oxford (United Kingdom)","University of Oxford,  United Kingdom"],"affiliations":[{"raw_affiliation_string":"Univ. of Oxford (United Kingdom)","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"University of Oxford,  United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079463167","display_name":"Esme J. Hill","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Esme J. Hill","raw_affiliation_strings":["Oxford Univ. Hospitals NHS Trust (United Kingdom)","Oxford University Hospitals NHS Trust, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"Oxford Univ. Hospitals NHS Trust (United Kingdom)","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Oxford University Hospitals NHS Trust, United Kingdom;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109905847","display_name":"Jamie Franklin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jamie Franklin","raw_affiliation_strings":["Oxford Univ. Hospitals NHS Trust (United Kingdom)","Oxford University Hospitals NHS Trust, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"Oxford Univ. Hospitals NHS Trust (United Kingdom)","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Oxford University Hospitals NHS Trust, United Kingdom;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020583325","display_name":"Ewan M. Anderson","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ewan M. Anderson","raw_affiliation_strings":["Oxford Univ. Hospitals NHS Trust (United Kingdom)","Oxford University Hospitals NHS Trust, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"Oxford Univ. Hospitals NHS Trust (United Kingdom)","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Oxford University Hospitals NHS Trust, United Kingdom;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024881638","display_name":"Ricky A. Sharma","orcid":"https://orcid.org/0000-0002-4873-9918"},"institutions":[{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ricky A. Sharma","raw_affiliation_strings":["Oxford Univ. Hospitals NHS Trust (United Kingdom)","Oxford University Hospitals NHS Trust, United Kingdom;"],"affiliations":[{"raw_affiliation_string":"Oxford Univ. Hospitals NHS Trust (United Kingdom)","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Oxford University Hospitals NHS Trust, United Kingdom;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019012882","display_name":"Julia A. Schnabel","orcid":"https://orcid.org/0000-0001-6107-3009"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia A. Schnabel","raw_affiliation_strings":["Univ. of Oxford (United Kingdom)","University of Oxford,  United Kingdom"],"affiliations":[{"raw_affiliation_string":"Univ. of Oxford (United Kingdom)","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"University of Oxford,  United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5014599500"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.266,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62867929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8669","issue":null,"first_page":"86690L","last_page":"86690L"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamic-contrast-enhanced-mri","display_name":"Dynamic contrast-enhanced MRI","score":0.7028269171714783},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.6778993606567383},{"id":"https://openalex.org/keywords/dynamic-contrast","display_name":"Dynamic contrast","score":0.5241853594779968},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.46403077244758606},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.45705389976501465},{"id":"https://openalex.org/keywords/arterial-blood","display_name":"Arterial blood","score":0.4563160836696625},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.45014458894729614},{"id":"https://openalex.org/keywords/perfusion-scanning","display_name":"Perfusion scanning","score":0.44888487458229065},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.43639522790908813},{"id":"https://openalex.org/keywords/blood-sampling","display_name":"Blood sampling","score":0.4355214238166809},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.41066282987594604},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34362542629241943},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33010438084602356},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.31332457065582275},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.3080381751060486},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27050527930259705},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.15367180109024048},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.11998805403709412}],"concepts":[{"id":"https://openalex.org/C41727105","wikidata":"https://www.wikidata.org/wiki/Q17009718","display_name":"Dynamic contrast-enhanced MRI","level":3,"score":0.7028269171714783},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6778993606567383},{"id":"https://openalex.org/C2994142346","wikidata":"https://www.wikidata.org/wiki/Q353268","display_name":"Dynamic contrast","level":3,"score":0.5241853594779968},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.46403077244758606},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.45705389976501465},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.4563160836696625},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.45014458894729614},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.44888487458229065},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.43639522790908813},{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.4355214238166809},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.41066282987594604},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34362542629241943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33010438084602356},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.31332457065582275},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3080381751060486},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27050527930259705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15367180109024048},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.11998805403709412},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1117/12.2007036","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2007036","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/ae9402c1-5b7d-455a-a370-8f8d9f491094","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/ae9402c1-5b7d-455a-a370-8f8d9f491094","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Enescu , M , Bhushan , M , Hill , E J , Franklin , J , Anderson , E M , Sharma , R A &amp; Schnabel , J A 2013 , pCT derived arterial input function for improved pharmacokinetic analysis of longitudinal dceMRI for colorectal cancer . in Progress in Biomedical Optics and Imaging - Proceedings of SPIE . vol. 8669 , 86690L , Medical Imaging 2013: Image Processing , Lake Buena Vista, FL , United States , 10/02/2013 . https://doi.org/10.1117/12.2007036","raw_type":"contributionToPeriodical"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:fbde1018-91f0-4635-8411-05330814f08e","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:fbde1018-91f0-4635-8411-05330814f08e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2419198331","https://openalex.org/W4391191811","https://openalex.org/W2377517991","https://openalex.org/W2982663588","https://openalex.org/W2347317511","https://openalex.org/W2783825050","https://openalex.org/W2085925393","https://openalex.org/W2392082309","https://openalex.org/W3135267232","https://openalex.org/W2378988804"],"abstract_inverted_index":{"Dynamic":[0],"contrast-enhanced":[1],"MRI":[2,102,206],"is":[3,9,77,95,109],"a":[4,87,134,168,231],"dynamic":[5,99,158,203],"imaging":[6],"technique":[7],"that":[8],"now":[10],"widely":[11],"used":[12,198],"for":[13,98,199],"cancer":[14,147],"imaging.":[15],"Changes":[16],"in":[17],"tumour":[18],"microvasculature":[19],"are":[20,216],"typically":[21],"quantified":[22],"by":[23,116],"pharmacokinetic":[24,32,103,200],"modelling":[25,201],"of":[26,39,167,202,212],"the":[27,37,40,55,67,71,165,181,185,213,220,227],"contrast":[28,100,159,204],"uptake":[29],"curves.":[30],"Reliable":[31],"parameter":[33,104,107],"estimation":[34,108],"depends":[35],"on":[36],"measurement":[38],"arterial":[41,49,60,91,137,187,193],"input":[42,72,92,138,188,194],"function,":[43,93,139],"which":[44,94],"can":[45,196],"be":[46,197],"obtained":[47,124,132],"from":[48,54,74],"blood":[50,61],"sampling,":[51],"or":[52],"extracted":[53],"image":[56,119],"data":[57],"directly.":[58],"However,":[59],"sampling":[62],"poses":[63],"additional":[64],"risks":[65],"to":[66,85,219,229],"patient,":[68],"and":[69,157,163,174,184,237],"extracting":[70],"function":[73],"MR":[75],"intensities":[76],"not":[78],"reliable.":[79],"In":[80],"this":[81,126],"work,":[82],"we":[83],"propose":[84],"compute":[86],"perfusion":[88,155,182,209,223],"CT":[89,156,183,191,210,224],"based":[90],"then":[96],"employed":[97],"enhanced":[101,160,205],"estimation.":[105],"Here,":[106],"performed":[110],"simultaneously":[111],"with":[112,125,130,153],"intra-sequence":[113],"motion":[114],"correction":[115],"using":[117,133,179],"nonlinear":[118],"registration.":[120],"K<sub>trans":[121],"</sub>":[122],"maps":[123],"approach":[127],"were":[128,177],"compared":[129],"those":[131],"population":[135],"averaged":[136],"i.e.":[140],"Orton.":[141],"The":[142],"dataset":[143],"comprised":[144],"5":[145],"rectal":[146],"patients,":[148],"who":[149],"had":[150],"been":[151],"imaged":[152],"both":[154,180],"MRI,":[161],"before":[162],"after":[164],"administration":[166],"radiosensitising":[169],"drug.":[170],"K<sub>trans</sub>":[171],"distributions":[172],"pre":[173],"post":[175],"therapy":[176],"computed":[178],"Orton":[186,221],"function.":[189],"Perfusion":[190],"derived":[192],"functions":[195,225],"data,":[207],"when":[208],"images":[211],"same":[214],"patients":[215],"available.":[217],"Compared":[218],"model,":[222],"have":[226],"potential":[228],"give":[230],"more":[232],"accurate":[233],"separation":[234],"between":[235],"responders":[236],"non-responders.":[238]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
