{"id":"https://openalex.org/W2033100295","doi":"https://doi.org/10.1117/12.2006389","title":"Cortical thickness estimation of the proximal femur from multi-view dual-energy X-ray absorptiometry (DXA)","display_name":"Cortical thickness estimation of the proximal femur from multi-view dual-energy X-ray absorptiometry (DXA)","publication_year":2013,"publication_date":"2013-02-28","ids":{"openalex":"https://openalex.org/W2033100295","doi":"https://doi.org/10.1117/12.2006389","mag":"2033100295"},"language":"en","primary_location":{"id":"doi:10.1117/12.2006389","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2006389","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017332805","display_name":"N. Tsaousis","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Tsaousis","raw_affiliation_strings":["Univ. of Cambridge (United Kingdom)","University of Cambridge , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cambridge (United Kingdom)","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"University of Cambridge , United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109294749","display_name":"AH Gee","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. H. Gee","raw_affiliation_strings":["Univ. of Cambridge (United Kingdom)","University of Cambridge , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cambridge (United Kingdom)","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"University of Cambridge , United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111977257","display_name":"G.M. Treece","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. M. Treece","raw_affiliation_strings":["Univ. of Cambridge (United Kingdom)","University of Cambridge , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cambridge (United Kingdom)","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"University of Cambridge , United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059434427","display_name":"Kenneth Poole","orcid":"https://orcid.org/0000-0003-4546-7352"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K.E.S. Poole","raw_affiliation_strings":["Univ. of Cambridge (United Kingdom)","University of Cambridge , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Cambridge (United Kingdom)","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"University of Cambridge , United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2052,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57373087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"8670","issue":null,"first_page":"86700B","last_page":"86700B"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gold-standard","display_name":"Gold standard (test)","score":0.665010392665863},{"id":"https://openalex.org/keywords/hip-fracture","display_name":"Hip fracture","score":0.5672048926353455},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5247883200645447},{"id":"https://openalex.org/keywords/femur","display_name":"Femur","score":0.5227232575416565},{"id":"https://openalex.org/keywords/radiography","display_name":"Radiography","score":0.5212103128433228},{"id":"https://openalex.org/keywords/dual-energy-x-ray-absorptiometry","display_name":"Dual-energy X-ray absorptiometry","score":0.4958833158016205},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"Osteoporosis","score":0.4910740852355957},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4226382076740265},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40016481280326843},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.36027252674102783},{"id":"https://openalex.org/keywords/bone-mineral","display_name":"Bone mineral","score":0.251539409160614},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.13312768936157227}],"concepts":[{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.665010392665863},{"id":"https://openalex.org/C2778885795","wikidata":"https://www.wikidata.org/wiki/Q240856","display_name":"Hip fracture","level":3,"score":0.5672048926353455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5247883200645447},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.5227232575416565},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.5212103128433228},{"id":"https://openalex.org/C2781440623","wikidata":"https://www.wikidata.org/wiki/Q444351","display_name":"Dual-energy X-ray absorptiometry","level":4,"score":0.4958833158016205},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4910740852355957},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4226382076740265},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40016481280326843},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.36027252674102783},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.251539409160614},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13312768936157227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1117/12.2006389","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2006389","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmh:oai:generic.eprints.org:577667","is_oa":false,"landing_page_url":"http://publications.eng.cam.ac.uk/577667/","pdf_url":null,"source":{"id":"https://openalex.org/S4406922847","display_name":"Cambridge University Engineering Department Publications Database","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W832193342","https://openalex.org/W1987850981","https://openalex.org/W610640263","https://openalex.org/W2527525423","https://openalex.org/W4367317527","https://openalex.org/W2784883928","https://openalex.org/W2002632872","https://openalex.org/W2374018790","https://openalex.org/W1988944825","https://openalex.org/W2107495478"],"abstract_inverted_index":{"Hip":[0],"fracture":[1,89],"is":[2,33,67,80,92,100],"the":[3,12,82,142,146,177,199,223,232,235],"leading":[4],"cause":[5],"of":[6,18,113,174,182,234],"acute":[7],"orthopaedic":[8],"hospital":[9],"admission":[10],"amongst":[11],"elderly,":[13],"with":[14,121,145],"around":[15],"a":[16,51,71,103,131,154,161,172,214],"third":[17],"patients":[19],"not":[20],"surviving":[21],"one":[22,210],"year":[23],"post-fracture.":[24],"Although":[25],"various":[26],"preventative":[27],"therapies":[28],"are":[29],"available,":[30],"patient":[31],"selection":[32],"difficult.":[34],"The":[35],"current":[36],"state-of-the-art":[37],"risk":[38,90],"assessment":[39],"tool":[40,104],"(FRAX)":[41],"ignores":[42],"focal":[43],"structural":[44],"defects,":[45],"such":[46],"as":[47,130],"cortical":[48,107,167],"bone":[49],"thinning,":[50],"critical":[52],"component":[53],"in":[54,95,198,222],"characterizing":[55],"hip":[56,88],"fragility.":[57],"Cortical":[58],"thickness":[59,108,143,168],"can":[60],"be":[61],"measured":[62],"using":[63,109,195,219],"CT,":[64],"but":[65],"this":[66,116,136],"expensive":[68],"and":[69,91,179,190],"involves":[70,153],"significant":[72],"radiation":[73],"dose.":[74],"Instead,":[75],"Dual-Energy":[76],"X-ray":[77],"Absorptiometry":[78],"(DXA)":[79],"currently":[81],"preferred":[83],"imaging":[84],"modality":[85],"for":[86,133],"assessing":[87],"used":[93],"routinely":[94],"clinical":[96],"practice.":[97],"Our":[98,151],"ambition":[99],"to":[101,105,139,164],"develop":[102],"measure":[106],"multi-view":[110],"DXA":[111,134],"instead":[112],"CT.":[114],"In":[115,171,213],"initial":[117],"study,":[118],"we":[119,186],"work":[120],"digitally":[122],"reconstructed":[123],"radiographs":[124],"(DRRs)":[125],"derived":[126],"from":[127],"CT":[128,149],"data":[129],"surrogate":[132],"scans:":[135],"enables":[137],"us":[138],"compare":[140],"directly":[141],"estimates":[144],"gold":[147],"standard":[148,211],"results.":[150],"approach":[152],"model-based":[155],"femoral":[156],"shape":[157],"reconstruction":[158],"followed":[159],"by":[160],"data-driven":[162],"algorithm":[163,189],"extract":[165],"numerous":[166],"point":[169],"estimates.":[170],"series":[173],"experiments":[175],"on":[176],"shaft":[178],"trochanteric":[180],"regions":[181],"48":[183],"proximal":[184],"femurs,":[185],"validated":[187],"our":[188],"established":[191],"its":[192],"performance":[193],"limits":[194],"20":[196],"views":[197,221],"range":[200,224],"0°\u2013171°:":[201],"estimation":[202],"errors":[203,238],"were":[204,239],"0:19":[205],"±":[206,241],"0:53mm":[207],"(mean":[208],"+/-":[209],"deviation).":[212],"more":[215],"clinically":[216],"viable":[217],"protocol":[218],"four":[220],"0°\u201351°,":[225],"where":[226],"no":[227],"other":[228],"bony":[229],"structures":[230],"obstruct":[231],"projection":[233],"femur,":[236],"measurement":[237],"−0:07":[240],"0:79":[242],"mm.":[243]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}