{"id":"https://openalex.org/W2118282875","doi":"https://doi.org/10.1109/tmi.2010.2045005","title":"Multiplexed Analysis of Proteins in Tissue Using Multispectral Fluorescence Imaging","display_name":"Multiplexed Analysis of Proteins in Tissue Using Multispectral Fluorescence Imaging","publication_year":2010,"publication_date":"2010-03-19","ids":{"openalex":"https://openalex.org/W2118282875","doi":"https://doi.org/10.1109/tmi.2010.2045005","mag":"2118282875","pmid":"https://pubmed.ncbi.nlm.nih.gov/20304722"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2010.2045005","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2010.2045005","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113837009","display_name":"Eugene Barash","orcid":null},"institutions":[{"id":"https://openalex.org/I1332737386","display_name":"General Electric (United States)","ror":"https://ror.org/013msgt25","country_code":"US","type":"company","lineage":["https://openalex.org/I1332737386"]},{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugene Barash","raw_affiliation_strings":["Applied Optics Laboratory, Global Research Center, General Electric, Niskayuna, NY 12309, USA. barash_eug@hotmail.com","Appl. Opt. Lab., Global Res. Center, Niskayuna, NY, USA"],"affiliations":[{"raw_affiliation_string":"Applied Optics Laboratory, Global Research Center, General Electric, Niskayuna, NY 12309, USA. barash_eug@hotmail.com","institution_ids":["https://openalex.org/I1332737386"]},{"raw_affiliation_string":"Appl. Opt. Lab., Global Res. Center, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013063930","display_name":"Sean R. Dinn","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]},{"id":"https://openalex.org/I1332737386","display_name":"General Electric (United States)","ror":"https://ror.org/013msgt25","country_code":"US","type":"company","lineage":["https://openalex.org/I1332737386"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Dinn","raw_affiliation_strings":["Biological and Organic Chemistry Laboratory, Global Research Center, General Electric Company Limited, Niskayuna, NY, USA","Biol. & Org. Chem. Laboraotry, Global Res. Center, Gen. Electr., Niskayuna, NY, USA"],"affiliations":[{"raw_affiliation_string":"Biological and Organic Chemistry Laboratory, Global Research Center, General Electric Company Limited, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I1332737386"]},{"raw_affiliation_string":"Biol. & Org. Chem. Laboraotry, Global Res. Center, Gen. Electr., Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076728915","display_name":"Christopher J. Sevinsky","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]},{"id":"https://openalex.org/I1332737386","display_name":"General Electric (United States)","ror":"https://ror.org/013msgt25","country_code":"US","type":"company","lineage":["https://openalex.org/I1332737386"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Sevinsky","raw_affiliation_strings":["Biochemistry and Biological Engineering Laboratory, Global Research Center, General Electric Company Limited, Niskayuna, NY, USA","Biochem. & Biol. Eng. Laboraotry, Global Res. Center, Gen. Electr., Niskayuna, NY, USA"],"affiliations":[{"raw_affiliation_string":"Biochemistry and Biological Engineering Laboratory, Global Research Center, General Electric Company Limited, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I1332737386"]},{"raw_affiliation_string":"Biochem. & Biol. Eng. Laboraotry, Global Res. Center, Gen. Electr., Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081260142","display_name":"Fiona Ginty","orcid":"https://orcid.org/0000-0001-6638-683X"},"institutions":[{"id":"https://openalex.org/I1332737386","display_name":"General Electric (United States)","ror":"https://ror.org/013msgt25","country_code":"US","type":"company","lineage":["https://openalex.org/I1332737386"]},{"id":"https://openalex.org/I4210134512","display_name":"GE Global Research (United States)","ror":"https://ror.org/03e06qt98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134512"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona Ginty","raw_affiliation_strings":["Computational Biology and Biostatistics Laboratory, Global Research Center, General Electric Company Limited, Niskayuna, NY, USA","Comput. Biol. & Biostat. Lab., Global Res. Center, Gen. Electr., Niskayuna, NY, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Biostatistics Laboratory, Global Research Center, General Electric Company Limited, Niskayuna, NY, USA","institution_ids":["https://openalex.org/I1332737386"]},{"raw_affiliation_string":"Comput. Biol. & Biostat. Lab., Global Res. Center, Gen. Electr., Niskayuna, NY, USA","institution_ids":["https://openalex.org/I4210134512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113837009"],"corresponding_institution_ids":["https://openalex.org/I1332737386","https://openalex.org/I4210134512"],"apc_list":null,"apc_paid":null,"fwci":5.3725,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.94825775,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":"8","first_page":"1457","last_page":"1462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multispectral-image","display_name":"Multispectral image","score":0.9015626907348633},{"id":"https://openalex.org/keywords/autofluorescence","display_name":"Autofluorescence","score":0.820104718208313},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.7656606435775757},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"Fluorescence-lifetime imaging microscopy","score":0.6588844656944275},{"id":"https://openalex.org/keywords/spectral-imaging","display_name":"Spectral imaging","score":0.572234034538269},{"id":"https://openalex.org/keywords/molecular-biophysics","display_name":"Molecular biophysics","score":0.5453975796699524},{"id":"https://openalex.org/keywords/multiplexing","display_name":"Multiplexing","score":0.5370437502861023},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.523205041885376},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3666163384914398},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32209792733192444},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2550840973854065},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17953446507453918},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.15773877501487732},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12772110104560852}],"concepts":[{"id":"https://openalex.org/C173163844","wikidata":"https://www.wikidata.org/wiki/Q1761440","display_name":"Multispectral image","level":2,"score":0.9015626907348633},{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.820104718208313},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7656606435775757},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.6588844656944275},{"id":"https://openalex.org/C3232514","wikidata":"https://www.wikidata.org/wiki/Q7575196","display_name":"Spectral imaging","level":2,"score":0.572234034538269},{"id":"https://openalex.org/C70636015","wikidata":"https://www.wikidata.org/wiki/Q4300350","display_name":"Molecular biophysics","level":2,"score":0.5453975796699524},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.5370437502861023},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.523205041885376},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3666163384914398},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32209792733192444},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2550840973854065},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17953446507453918},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.15773877501487732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12772110104560852},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002232","descriptor_name":"Carbocyanines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002232","descriptor_name":"Carbocyanines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002232","descriptor_name":"Carbocyanines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2010.2045005","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2010.2045005","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:20304722","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20304722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1968483494","https://openalex.org/W1976391658","https://openalex.org/W1989790390","https://openalex.org/W2003752781","https://openalex.org/W2094272082","https://openalex.org/W2094695556","https://openalex.org/W2120710405","https://openalex.org/W2126032703","https://openalex.org/W2135029798","https://openalex.org/W2154141761","https://openalex.org/W2217785159","https://openalex.org/W2297029744","https://openalex.org/W3143596294","https://openalex.org/W6680012447"],"related_works":["https://openalex.org/W2051334599","https://openalex.org/W2078437878","https://openalex.org/W1966978880","https://openalex.org/W2037276225","https://openalex.org/W2016359086","https://openalex.org/W2015264016","https://openalex.org/W1833947617","https://openalex.org/W2312362296","https://openalex.org/W943367353","https://openalex.org/W2009432835"],"abstract_inverted_index":{"We":[0],"present":[1,27],"a":[2,84,108],"new":[3],"application":[4],"of":[5,11,24,43,60,72,86,121],"multispectral":[6],"analysis":[7,40,120],"for":[8,118],"subcellular":[9],"measurement":[10],"multiple":[12],"proteins":[13],"in":[14,28,107],"formalin-fixed":[15],"paraffin":[16],"embedded":[17],"tissue":[18],"and":[19,41,92,123],"cells.":[20,124],"Typically,":[21],"the":[22,29,44,70,89],"targets":[23,106],"interest":[25],"are":[26,55],"same":[30,90],"or":[31],"spatially":[32],"overlapping":[33,53],"cellular":[34],"compartments.":[35],"Such":[36],"co-localization":[37],"can":[38,75],"complicate":[39],"interpretation":[42],"images":[45],"obtained":[46],"using":[47],"traditional":[48,80],"fluorescence,":[49],"especially":[50],"when":[51],"spectrally":[52],"labels":[54],"present.":[56],"The":[57],"spectral":[58],"properties":[59],"currently":[61],"available":[62],"fluorescent":[63],"dyes":[64],"set":[65,85],"an":[66],"upper":[67],"limit":[68],"to":[69,103],"number":[71],"molecules":[73],"that":[74],"be":[76],"detected":[77],"simultaneously":[78],"with":[79],"fluorescence.":[81],"By":[82],"exciting":[83],"fluorophores":[87],"at":[88],"wavelength":[91],"unmixing":[93],"their":[94],"emission":[95],"signals":[96],"from":[97],"background":[98],"autofluorescence,":[99],"we":[100],"were":[101],"able":[102],"image":[104],"three":[105],"single":[109],"channel.":[110],"This":[111],"parallel":[112],"imaging":[113],"approach":[114],"provides":[115],"significant":[116],"advantages":[117],"multiplexed":[119],"tissues":[122]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-03-13T16:22:10.518609","created_date":"2025-10-10T00:00:00"}
