{"id":"https://openalex.org/W4378192168","doi":"https://doi.org/10.1109/syscon53073.2023.10131047","title":"Adverse Outcome Pathways for Engineered Systems","display_name":"Adverse Outcome Pathways for Engineered Systems","publication_year":2023,"publication_date":"2023-04-17","ids":{"openalex":"https://openalex.org/W4378192168","doi":"https://doi.org/10.1109/syscon53073.2023.10131047"},"language":"en","primary_location":{"id":"doi:10.1109/syscon53073.2023.10131047","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/syscon53073.2023.10131047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Systems Conference (SysCon)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080614251","display_name":"R. Cody Salter","orcid":null},"institutions":[{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]},{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"funder","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]},{"id":"https://openalex.org/I4210126846","display_name":"Information Technology Laboratory","ror":"https://ror.org/0440c3437","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4210126846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Cody Salter","raw_affiliation_strings":["U.S. Army Engineer Research and Development Center,Information Technology Laboratory,Vicksburg,MS","Information Technology Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS"],"affiliations":[{"raw_affiliation_string":"U.S. Army Engineer Research and Development Center,Information Technology Laboratory,Vicksburg,MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792","https://openalex.org/I4210126846"]},{"raw_affiliation_string":"Information Technology Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792","https://openalex.org/I4210126846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018814543","display_name":"Nat\u00e0lia Garcia-Reyero","orcid":null},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"funder","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]},{"id":"https://openalex.org/I4210126846","display_name":"Information Technology Laboratory","ror":"https://ror.org/0440c3437","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4210126846"]},{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nat\u00e0lia Garcia-Reyero","raw_affiliation_strings":["U.S. Army Engineer Research and Development Center,Information Technology Laboratory,Vicksburg,MS","Information Technology Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS"],"affiliations":[{"raw_affiliation_string":"U.S. Army Engineer Research and Development Center,Information Technology Laboratory,Vicksburg,MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792","https://openalex.org/I4210126846"]},{"raw_affiliation_string":"Information Technology Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792","https://openalex.org/I4210126846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064658033","display_name":"Alicia Ruvinsky","orcid":null},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"funder","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]},{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Ruvinsky","raw_affiliation_strings":["U.S. Army Engineer Research and Development Center,Environmental Laboratory,Vicksburg,MS","Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS"],"affiliations":[{"raw_affiliation_string":"U.S. Army Engineer Research and Development Center,Environmental Laboratory,Vicksburg,MS","institution_ids":["https://openalex.org/I87303767"]},{"raw_affiliation_string":"Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032889863","display_name":"Maria Seale","orcid":"https://orcid.org/0000-0003-3858-0381"},"institutions":[{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]},{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"funder","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]},{"id":"https://openalex.org/I4210126846","display_name":"Information Technology Laboratory","ror":"https://ror.org/0440c3437","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065","https://openalex.org/I4210126846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Seale","raw_affiliation_strings":["U.S. Army Engineer Research and Development Center,Information Technology Laboratory,Vicksburg,MS","Information Technology Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS"],"affiliations":[{"raw_affiliation_string":"U.S. Army Engineer Research and Development Center,Information Technology Laboratory,Vicksburg,MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792","https://openalex.org/I4210126846"]},{"raw_affiliation_string":"Information Technology Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792","https://openalex.org/I4210126846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075371599","display_name":"Edward J. Perkins","orcid":"https://orcid.org/0000-0003-1693-7714"},"institutions":[{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]},{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"funder","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Perkins","raw_affiliation_strings":["U.S. Army Engineer Research and Development Center,Environmental Laboratory,Vicksburg,MS","Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS"],"affiliations":[{"raw_affiliation_string":"U.S. Army Engineer Research and Development Center,Environmental Laboratory,Vicksburg,MS","institution_ids":["https://openalex.org/I87303767"]},{"raw_affiliation_string":"Environmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS","institution_ids":["https://openalex.org/I87303767","https://openalex.org/I4210088792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080614251"],"corresponding_institution_ids":["https://openalex.org/I4210088792","https://openalex.org/I4210126846","https://openalex.org/I87303767"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08583515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"507","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11357","display_name":"Risk and Safety Analysis","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11357","display_name":"Risk and Safety Analysis","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10809","display_name":"Occupational Health and Safety Research","score":0.9674999713897705,"subfield":{"id":"https://openalex.org/subfields/3614","display_name":"Radiological and Ultrasound Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13690","display_name":"Quality and Safety in Healthcare","score":0.9567999839782715,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/documentation","display_name":"Documentation","score":0.7178596258163452},{"id":"https://openalex.org/keywords/adverse-outcome-pathway","display_name":"Adverse Outcome Pathway","score":0.6128515005111694},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5366707444190979},{"id":"https://openalex.org/keywords/knowledge-management","display_name":"Knowledge management","score":0.5028631091117859},{"id":"https://openalex.org/keywords/attrition","display_name":"Attrition","score":0.5025570392608643},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.4822536110877991},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.4591722786426544},{"id":"https://openalex.org/keywords/outcome","display_name":"Outcome (game theory)","score":0.4425974488258362},{"id":"https://openalex.org/keywords/business","display_name":"Business","score":0.20173245668411255},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17686283588409424},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14702263474464417}],"concepts":[{"id":"https://openalex.org/C56666940","wikidata":"https://www.wikidata.org/wiki/Q788790","display_name":"Documentation","level":2,"score":0.7178596258163452},{"id":"https://openalex.org/C2910206359","wikidata":"https://www.wikidata.org/wiki/Q18559532","display_name":"Adverse Outcome Pathway","level":2,"score":0.6128515005111694},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5366707444190979},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.5028631091117859},{"id":"https://openalex.org/C2780553607","wikidata":"https://www.wikidata.org/wiki/Q684868","display_name":"Attrition","level":2,"score":0.5025570392608643},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4822536110877991},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4591722786426544},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.4425974488258362},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.20173245668411255},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17686283588409424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14702263474464417},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/syscon53073.2023.10131047","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/syscon53073.2023.10131047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Systems Conference (SysCon)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1496395723","https://openalex.org/W1935903675","https://openalex.org/W2000089305","https://openalex.org/W2155848441","https://openalex.org/W2313757172","https://openalex.org/W3157686156","https://openalex.org/W3169866837","https://openalex.org/W4220776990","https://openalex.org/W4233508594","https://openalex.org/W4239389501","https://openalex.org/W4244336198","https://openalex.org/W4252518539","https://openalex.org/W4253339311","https://openalex.org/W4285106626","https://openalex.org/W4285794559","https://openalex.org/W4379143208"],"related_works":["https://openalex.org/W1969175355","https://openalex.org/W2007101045","https://openalex.org/W2056472298","https://openalex.org/W4389273703","https://openalex.org/W2586909830","https://openalex.org/W4231153204","https://openalex.org/W2775846538","https://openalex.org/W2116688168","https://openalex.org/W3124528783","https://openalex.org/W2900291040"],"abstract_inverted_index":{"Companies":[0],"and":[1,16,31,38,44,69,84,110,130,176,198,216],"organizations":[2,45],"around":[3,73],"the":[4,74,122,126,131,137,142,146,158,177,187,195,203,207,212],"world":[5],"spend":[6],"massive":[7],"amounts":[8],"of":[9,55,67,76,89,112,124,128,133,139,157,179,181,189,211],"money":[10],"each":[11],"year":[12],"to":[13,36,58,98,106,169],"discover,":[14],"predict,":[15],"remediate":[17],"failures":[18,180],"within":[19],"engineered":[20,117,183],"systems.":[21],"By":[22],"doing":[23],"so,":[24],"these":[25,41],"groups":[26],"save":[27],"lives,":[28],"reduce":[29],"costs,":[30],"maintain":[32],"their":[33],"reputations.":[34],"However,":[35],"effectively":[37],"efficiently":[39],"perform":[40],"tasks,":[42],"companies":[43],"rely":[46],"on":[47,186],"individuals":[48],"with":[49],"specialized":[50],"knowledge":[51,61,91,102,172,174],"in":[52,121,163],"a":[53,99],"variety":[54],"topics":[56],"related":[57],"failure.":[59,140],"This":[60,192],"is":[62,103,167,214],"often":[63,104],"acquired":[64],"through":[65,92],"years":[66],"academic":[68],"on-the-job":[70],"training":[71],"centered":[72],"review":[75],"scientific":[77],"documentation":[78],"such":[79],"as":[80,101],"books,":[81],"reports,":[82],"manuals,":[83],"peer-reviewed":[85],"publications.":[86],"The":[87,108,165],"loss":[88],"this":[90],"employee":[93],"attrition":[94],"can":[95],"be":[96],"detrimental":[97],"group":[100],"difficult":[105],"reacquire.":[107],"aggregation":[109],"representation":[111],"known":[113],"failure":[114,134,171],"mechanisms":[115],"for":[116,150],"materials":[118,184],"could":[119],"aid":[120],"sharing":[123],"knowledge,":[125,129],"acquisition":[127],"discovery":[132],"causes,":[135],"reducing":[136],"risk":[138],"Thus,":[141],"current":[143],"work":[144],"proposes":[145],"Adverse":[147,159],"Outcome":[148,160],"Pathway":[149,161],"Engineered":[151],"Systems":[152],"(AOP-ES)":[153],"framework,":[154],"an":[155],"extension":[156],"used":[162],"toxicology.":[164],"AOP-ES":[166,196],"designed":[168],"document":[170],"enabling":[173],"transfer":[175],"prediction":[178],"novel":[182],"based":[185],"performance":[188],"similar":[190],"materials.":[191],"paper":[193],"introduces":[194],"framework":[197,213],"its":[199],"key":[200],"elements":[201],"alongside":[202],"principles":[204],"that":[205],"govern":[206],"framework.":[208],"An":[209],"application":[210],"presented":[215],"additional":[217],"benefits":[218],"are":[219],"explored.":[220]},"counts_by_year":[],"updated_date":"2025-12-24T23:09:58.560324","created_date":"2025-10-10T00:00:00"}
