{"id":"https://openalex.org/W4390481587","doi":"https://doi.org/10.1109/sipaim56729.2023.10373510","title":"Can Structural MRIs be used to Detect Amyloid Positivity using Deep Learning?","display_name":"Can Structural MRIs be used to Detect Amyloid Positivity using Deep Learning?","publication_year":2023,"publication_date":"2023-11-15","ids":{"openalex":"https://openalex.org/W4390481587","doi":"https://doi.org/10.1109/sipaim56729.2023.10373510"},"language":"en","primary_location":{"id":"doi:10.1109/sipaim56729.2023.10373510","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/sipaim56729.2023.10373510","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 19th International Symposium on Medical Information Processing and Analysis (SIPAIM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074576951","display_name":"Tamoghna Chattopadhyay","orcid":"https://orcid.org/0000-0002-3146-6845"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tamoghna Chattopadhyay","raw_affiliation_strings":["Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016297505","display_name":"Dheeraj Komandur","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dheeraj Komandur","raw_affiliation_strings":["Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111104346","display_name":"Jayati Naik","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayati Naik","raw_affiliation_strings":["Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048439744","display_name":"Ketaki Buwa","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ketaki Buwa","raw_affiliation_strings":["Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024446214","display_name":"Saket S. Ozarkar","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saket S. Ozarkar","raw_affiliation_strings":["Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017365268","display_name":"Sophia I. Thomopoulos","orcid":"https://orcid.org/0000-0002-0046-4070"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia I. Thomopoulos","raw_affiliation_strings":["Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,United States","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5074576951"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30968363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6018028855323792},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6003677248954773},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.5598345994949341},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4844937026500702},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.34304505586624146},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3376476764678955},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22517627477645874},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15996387600898743}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6018028855323792},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6003677248954773},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5598345994949341},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4844937026500702},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.34304505586624146},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3376476764678955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22517627477645874},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15996387600898743}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sipaim56729.2023.10373510","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/sipaim56729.2023.10373510","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 19th International Symposium on Medical Information Processing and Analysis (SIPAIM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","score":0.6399999856948853,"id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1982146721","https://openalex.org/W1993571512","https://openalex.org/W2030486772","https://openalex.org/W2051489981","https://openalex.org/W2053819172","https://openalex.org/W2087924155","https://openalex.org/W2113518834","https://openalex.org/W2134711807","https://openalex.org/W2143282099","https://openalex.org/W2152575748","https://openalex.org/W2168283959","https://openalex.org/W2480170620","https://openalex.org/W2891669248","https://openalex.org/W2897862050","https://openalex.org/W2964629181","https://openalex.org/W2968364625","https://openalex.org/W2971149745","https://openalex.org/W3111777727","https://openalex.org/W3165823254","https://openalex.org/W4206550650","https://openalex.org/W4220867605","https://openalex.org/W4287594639","https://openalex.org/W4304893033","https://openalex.org/W4320013936","https://openalex.org/W6786092983"],"related_works":["https://openalex.org/W2731899572","https://openalex.org/W3215138031","https://openalex.org/W3009238340","https://openalex.org/W4321369474","https://openalex.org/W4360585206","https://openalex.org/W4285208911","https://openalex.org/W3082895349","https://openalex.org/W4213079790","https://openalex.org/W2248239756","https://openalex.org/W4323565446"],"abstract_inverted_index":{"Abnormal":[0],"\u03b2-amyloid":[1],"(A\u03b2)":[2],"accumulation":[3],"in":[4,42],"the":[5,98,114,151,169,180,184,189],"brain":[6,54],"is":[7,15,39],"an":[8],"early":[9],"indicator":[10],"of":[11,100,150,178,196],"Alzheimer\u2019s":[12,152],"disease":[13],"and":[14,78,91,103,143,165,183],"assessed":[16],"using":[17],"PET":[18],"or":[19],"CSF":[20,200],"assays,":[21],"both":[22,101],"highly":[23],"invasive":[24,60,226],"procedures.":[25,227],"As":[26],"new":[27],"anti-Alzheimer\u2019s":[28],"treatments":[29],"have":[30],"recently":[31],"been":[32],"developed":[33],"to":[34],"target":[35],"amyloid":[36,116],"pathology,":[37],"there":[38],"great":[40],"interest":[41],"understanding":[43],"how":[44],"well":[45],"A\u03b2":[46],"positivity":[47],"(A\u03b2+)":[48],"can":[49],"be":[50],"predicted":[51],"from":[52,128,215],"Tl-weighted":[53],"MRI":[55,217],"(T1w),":[56],"as":[57,148,202],"a":[58,110,175,193],"less":[59],"alternative.":[61],"For":[62],"this":[63],"A\u03b2+":[64,221],"prediction":[65,117],"task,":[66],"we":[67,107],"compared":[68,158],"(1)":[69],"classical":[70,170],"machine":[71,171],"learning":[72,86,172],"algorithms":[73,173],"(including":[74],"logistic":[75],"regression,":[76],"XGBoost":[77],"shallow":[79,102],"artificial":[80],"neural":[81,94,105],"networks)":[82],"versus":[83],"(2)":[84],"deep":[85,104,212],"models,":[87],"based":[88,159],"on":[89,123,160,206],"2D":[90],"3D":[92,185],"convolutional":[93],"networks.":[95],"To":[96],"combine":[97],"strengths":[99],"networks,":[106],"also":[108],"tested":[109],"hybrid":[111,181],"ANN-CNN":[112],"for":[113,220],"same":[115],"task.":[118],"All":[119],"models":[120,214],"were":[121,157],"trained":[122],"paired":[124],"MRI/PET":[125],"data":[126,209],"collected":[127],"762":[129],"elderly":[130],"subjects":[131],"(mean":[132],"age:":[133],"75.1":[134],"yrs.":[135],"\u00b17.6SD;394F/368M;":[136],"459":[137],"healthy":[138],"controls,":[139],"67":[140],"with":[141,145,198],"MCI":[142],"236":[144],"dementia)":[146],"scanned":[147],"part":[149],"Disease":[153],"Neuroimaging":[154],"Initiative.":[155],"Results":[156],"each":[161],"model\u2019s":[162],"balanced":[163,176,194],"accuracy":[164,177,195],"F1":[166],"scores.":[167],"Though":[168],"gave":[174],"0.771,":[179],"network":[182],"CNN":[186,190],"performed":[187],"best-":[188],"alone":[191],"yielded":[192],"0.815":[197],"MRI-derived":[199],"maps":[201],"input.":[203],"Although":[204],"tests":[205],"more":[207,225],"diverse":[208],"are":[210],"warranted,":[211],"learned":[213],"standard":[216],"show":[218],"promise":[219],"estimation,":[222],"before":[223],"considering":[224]},"counts_by_year":[],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2025-10-10T00:00:00"}