{"id":"https://openalex.org/W2501931435","doi":"https://doi.org/10.1109/rait.2016.7507956","title":"Identification of miRNA signature using Next-Generation Sequencing data of prostate cancer","display_name":"Identification of miRNA signature using Next-Generation Sequencing data of prostate cancer","publication_year":2016,"publication_date":"2016-03-01","ids":{"openalex":"https://openalex.org/W2501931435","doi":"https://doi.org/10.1109/rait.2016.7507956","mag":"2501931435"},"language":"en","primary_location":{"id":"doi:10.1109/rait.2016.7507956","is_oa":false,"landing_page_url":"https://doi.org/10.1109/rait.2016.7507956","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 3rd International Conference on Recent Advances in Information Technology (RAIT)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054354968","display_name":"Shib Sankar Bhowmick","orcid":"https://orcid.org/0000-0002-3058-0478"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shib Sankar Bhowmick","raw_affiliation_strings":["Dept. of Electronics & Communication Engineering, Heritage Institute of Technology, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electronics & Communication Engineering, Heritage Institute of Technology, Kolkata, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003577135","display_name":"Indrajit Saha","orcid":"https://orcid.org/0000-0001-9513-9707"},"institutions":[{"id":"https://openalex.org/I4210094264","display_name":"National Institute of Technical Teachers\u2019 Training and Research","ror":"https://ror.org/00k8f0f41","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210094264"]},{"id":"https://openalex.org/I4210094717","display_name":"National Institute of Technical Teachers Training and Research","ror":"https://ror.org/00rpc7w94","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210094717"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Indrajit Saha","raw_affiliation_strings":["National Institute of Technical, Teachers Training & Research, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Technical, Teachers Training & Research, Kolkata, India","institution_ids":["https://openalex.org/I4210094264","https://openalex.org/I4210094717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072356717","display_name":"Ujjwal Maulik","orcid":"https://orcid.org/0000-0003-1167-0774"},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ujjwal Maulik","raw_affiliation_strings":["Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, India","institution_ids":["https://openalex.org/I170979836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075849780","display_name":"Debotosh Bhattacharjee","orcid":"https://orcid.org/0000-0002-1163-6413"},"institutions":[{"id":"https://openalex.org/I170979836","display_name":"Jadavpur University","ror":"https://ror.org/02af4h012","country_code":"IN","type":"education","lineage":["https://openalex.org/I170979836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debotosh Bhattacharjee","raw_affiliation_strings":["Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science and Engineering, Jadavpur University, Kolkata, India","institution_ids":["https://openalex.org/I170979836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3985,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65998119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2","issue":null,"first_page":"528","last_page":"533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.6667593717575073},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6433421969413757},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5973654389381409},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5953986048698425},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.5659930109977722},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5454984903335571},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4361097812652588},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.41952741146087646},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35663503408432007},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3255279064178467},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29238906502723694},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1797659993171692},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16080477833747864}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6667593717575073},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6433421969413757},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5973654389381409},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5953986048698425},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.5659930109977722},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5454984903335571},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4361097812652588},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.41952741146087646},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35663503408432007},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3255279064178467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29238906502723694},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1797659993171692},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16080477833747864}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/rait.2016.7507956","is_oa":false,"landing_page_url":"https://doi.org/10.1109/rait.2016.7507956","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 3rd International Conference on Recent Advances in Information Technology (RAIT)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.6499999761581421,"display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1531443972","https://openalex.org/W1565050238","https://openalex.org/W1967573895","https://openalex.org/W1974758710","https://openalex.org/W1986700282","https://openalex.org/W1993589337","https://openalex.org/W2022306346","https://openalex.org/W2056618769","https://openalex.org/W2074136202","https://openalex.org/W2087347434","https://openalex.org/W2109363337","https://openalex.org/W2111761681","https://openalex.org/W2124776405","https://openalex.org/W2149772057","https://openalex.org/W2154053567","https://openalex.org/W2155653793","https://openalex.org/W2325343629","https://openalex.org/W2398429457","https://openalex.org/W2403848019","https://openalex.org/W2404759350","https://openalex.org/W2799061466","https://openalex.org/W3016230452","https://openalex.org/W4239875977","https://openalex.org/W4298018660","https://openalex.org/W6633926026","https://openalex.org/W6656934350","https://openalex.org/W6723941685","https://openalex.org/W7014191107","https://openalex.org/W7074581528"],"related_works":["https://openalex.org/W2965546495","https://openalex.org/W4389116644","https://openalex.org/W2153315159","https://openalex.org/W3103844505","https://openalex.org/W259157601","https://openalex.org/W4205463238","https://openalex.org/W2761785940","https://openalex.org/W1482209366","https://openalex.org/W2110523656","https://openalex.org/W1487808658"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,25,189,286],"a":[3,27,54,90,126,141,248,265],"class":[4],"of":[5,34,47,70,96,164,172,178,195,214,250,262,267,276,294,317],"~22-nucleotide":[6],"endogenous":[7],"noncoding":[8],"RNAs":[9,43],"which":[10],"have":[11,312],"critical":[12],"functions":[13],"across":[14],"various":[15],"biological":[16,322],"processes.":[17],"It":[18],"is":[19,56,80,89,116,135,182,216,269],"quite":[20],"well-known":[21],"that":[22,198,277],"the":[23,32,94,101,179,192,199,211,244,259,272,292,295,309,326],"miRNAs":[24,251,268,275],"playing":[26],"crucial":[28],"role":[29],"for":[30,60,83,113,132,325],"regulating":[31],"expression":[33,111],"target":[35],"gene":[36],"via":[37],"repressing":[38],"translation":[39],"or":[40],"promoting":[41],"messenger":[42],"degradation.":[44],"Therefore,":[45],"identification":[46,130],"discriminative":[48],"and":[49,153,284],"differentially":[50],"expressed":[51],"miRNA":[52,105,110,128,241],"as":[53,98,218,232],"signature":[55,106,129],"an":[57,117,219],"important":[58,118],"task":[59,201],"cancer":[61,87,115,134],"therapy.":[62],"In":[63],"this":[64,124,167,263],"regard,":[65],"Next-Generation":[66],"Sequencing":[67],"(NGS)":[68],"data":[69,112,196],"miRNAs,":[71,280],"available":[72],"at":[73],"The":[74,137,226],"Cancer":[75],"Research":[76],"Atlas":[77],"(TCGA)":[78],"repository,":[79],"analyzed":[81],"here":[82],"prostate":[84,114,133,289],"cancer.":[85,290],"This":[86],"type":[88],"serious":[91],"threat":[92],"to":[93,222,238,258],"health":[95],"men":[97],"found":[99],"in":[100,166,236],"literature.":[102],"Hence,":[103],"finding":[104],"using":[107,184,208,224],"NGS":[108],"based":[109],"research":[119],"direction.":[120],"Generally":[121],"by":[122,315],"motivating":[123],"fact,":[125],"new":[127],"method":[131,139,228,297],"proposed.":[136],"proposed":[138,227,296],"uses":[140],"global":[142],"optimization":[143],"technique,":[144],"called":[145],"Simulated":[146],"Annealing":[147],"(SA),":[148],"Principal":[149],"Component":[150],"Analysis":[151],"(PCA)":[152],"Support":[154],"Vector":[155],"Machine":[156],"(SVM)":[157],"classifier.":[158],"Here":[159,210],"SA":[160],"encodes":[161],"L":[162,174],"number":[163,171],"features,":[165],"case":[168],"miRNAs.":[169,328],"Similar":[170],"top":[173,273],"key":[175],"principal":[176],"components":[177,188],"original":[180],"dataset":[181,207],"extracted":[183],"PCA.":[185],"Thereafter,":[186],"such":[187],"multiplied":[190],"with":[191,252,288,302,321],"reduced":[193],"subset":[194],"so":[197],"classification":[200,212,254],"can":[202,229],"be":[203,230],"done":[204],"on":[205],"diverse":[206],"SVM.":[209],"accuracy":[213],"SVM":[215],"considered":[217],"underlying":[220],"objective":[221],"optimize":[223],"SA.":[225],"seen":[231],"feature":[233],"section":[234],"technique":[235],"order":[237],"find":[239],"potential":[240],"signature.":[242],"Finally,":[243],"experimental":[245],"results":[246,311],"provide":[247],"set":[249],"optimal":[253],"accuracy.":[255],"However,":[256],"due":[257],"stochastic":[260],"nature":[261],"algorithm":[264],"list":[266],"prepared.":[270],"From":[271],"15":[274],"list,":[278],"four":[279],"hsa-mir-152,":[281],"hsa-mir-23a,":[282],"hsa-mir-302f":[283],"hsa-mir-101-1,":[285],"associated":[287],"Moreover,":[291],"performance":[293],"has":[298],"also":[299],"been":[300,313],"compared":[301],"other":[303],"widely":[304],"used":[305],"state-of-the-art":[306],"techniques.":[307],"Furthermore,":[308],"obtained":[310],"justified":[314],"means":[316],"statistical":[318],"test":[319],"along":[320],"significance":[323],"tests":[324],"selected":[327]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}