{"id":"https://openalex.org/W2152648970","doi":"https://doi.org/10.1109/nems.2011.6017402","title":"Adhesion strengths of normal epithelial cells and epithelial mesenchymal transition cells by using single-cell force spectroscopy","display_name":"Adhesion strengths of normal epithelial cells and epithelial mesenchymal transition cells by using single-cell force spectroscopy","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W2152648970","doi":"https://doi.org/10.1109/nems.2011.6017402","mag":"2152648970"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2011.6017402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2011.6017402","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005866572","display_name":"Wen\u2010Ling Chen","orcid":"https://orcid.org/0000-0001-5143-0543"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wen-Ling Chen","raw_affiliation_strings":["Institute of Biomedical Engineering, National Cheng Kung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050350856","display_name":"Yi-Shan Chung","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Shan Chung","raw_affiliation_strings":["Institute of Biomedical Engineering, National Cheng Kung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034705197","display_name":"Yu\u2010Wei Chiou","orcid":null},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Wei Chiou","raw_affiliation_strings":["Institute of Biomedical Engineering, National Cheng Kung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071217303","display_name":"Ming\u2010Jer Tang","orcid":"https://orcid.org/0000-0002-0883-4363"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Jer Tang","raw_affiliation_strings":["Institute of Physiology, National Cheng Kung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Physiology, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068362288","display_name":"Ming\u2010Long Yeh","orcid":"https://orcid.org/0000-0001-6942-060X"},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Long Yeh","raw_affiliation_strings":["Institute of Biomedical Engineering, National Cheng Kung University, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, National Cheng Kung University, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005866572"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14627419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"499","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9817000031471252,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/force-spectroscopy","display_name":"Force spectroscopy","score":0.7549489736557007},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell","display_name":"Mesenchymal stem cell","score":0.6985520124435425},{"id":"https://openalex.org/keywords/epithelial\u2013mesenchymal-transition","display_name":"Epithelial\u2013mesenchymal transition","score":0.5970653891563416},{"id":"https://openalex.org/keywords/adhesion","display_name":"Adhesion","score":0.5944321751594543},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5866696834564209},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"Cell adhesion","score":0.5792267918586731},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.557659924030304},{"id":"https://openalex.org/keywords/fibroblast","display_name":"Fibroblast","score":0.512500524520874},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5016412734985352},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4574843943119049},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.4495936930179596},{"id":"https://openalex.org/keywords/focal-adhesion","display_name":"Focal adhesion","score":0.4208759665489197},{"id":"https://openalex.org/keywords/cell-adhesion-molecule","display_name":"Cell adhesion molecule","score":0.41527557373046875},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.37735021114349365},{"id":"https://openalex.org/keywords/atomic-force-microscopy","display_name":"Atomic force microscopy","score":0.31056493520736694},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.2570200562477112},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.24999114871025085},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22665488719940186},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.13274183869361877},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08381631970405579},{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.07911813259124756}],"concepts":[{"id":"https://openalex.org/C119473381","wikidata":"https://www.wikidata.org/wiki/Q49298","display_name":"Force spectroscopy","level":3,"score":0.7549489736557007},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6985520124435425},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5970653891563416},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5944321751594543},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5866696834564209},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5792267918586731},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.557659924030304},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.512500524520874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5016412734985352},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4574843943119049},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4495936930179596},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.4208759665489197},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.41527557373046875},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37735021114349365},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.31056493520736694},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2570200562477112},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24999114871025085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22665488719940186},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13274183869361877},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08381631970405579},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.07911813259124756},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nems.2011.6017402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2011.6017402","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4399999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2047992261","https://openalex.org/W2077318098"],"related_works":["https://openalex.org/W2766388078","https://openalex.org/W4236534487","https://openalex.org/W4238125241","https://openalex.org/W2123305987","https://openalex.org/W4243357640","https://openalex.org/W4256051592","https://openalex.org/W4255612473","https://openalex.org/W4236500874","https://openalex.org/W4230807376","https://openalex.org/W2186490440"],"abstract_inverted_index":{"The":[0,41,85,100,115],"epithelial":[1,125,140],"to":[2,56,139,157],"mesenchymal":[3,116,143],"transitions":[4],"(EMT)":[5],"plays":[6],"essential":[7],"roles":[8],"in":[9,35,82,163],"many":[10],"physiological":[11],"and":[12,19,38,66,75,96,108,131,142,155,160],"pathological":[13],"processes":[14],"such":[15],"as":[16,26],"embryonic":[17],"development":[18],"cancer":[20],"progression.":[21],"Transforming":[22],"growth":[23],"factor-\u03b2":[24],"(TGF-\u03b2)":[25],"an":[27],"inducer":[28],"of":[29,43,102,153],"EMT":[30,79,154],"that":[31],"causes":[32],"complex":[33],"changes":[34],"cell":[36,128],"morphology":[37,101],"adhesion":[39,60,121],"properties.":[40],"purpose":[42],"present":[44],"study":[45,57],"was":[46,89],"using":[47],"atomic":[48],"force":[49,53,65,130],"microscopy":[50],"(AFM)-based":[51],"single-cell":[52],"spectroscopy":[54],"(SCFS)":[55],"the":[58,63,124,135,150],"cell-matrix":[59],"properties":[61,122],"including":[62,127],"detachment":[64,129],"contact":[67,87,132],"stiffness.":[68,133],"Normal":[69],"murine":[70],"mammary":[71],"gland":[72],"(NMuMG)":[73],"cells":[74,77,104,117,141,144],"NMuMG":[76,103],"after":[78,111],"were":[80],"used":[81],"this":[83],"study.":[84],"cell-substrate":[86],"duration":[88],"set":[90],"at":[91],"30":[92],"sec,":[93,98],"60":[94],"sec":[95],"300":[97],"respectively.":[99],"grew":[105],"into":[106],"separately":[107],"fibroblast-like":[109],"shape":[110],"48-hour":[112],"TGF-al":[113],"treatment.":[114],"exhibited":[118],"stronger":[119],"overall":[120],"than":[123],"cells,":[126],"Furthermore,":[134],"mechanical":[136],"behavior":[137],"related":[138],"could":[145],"provide":[146],"better":[147],"elucidation":[148],"for":[149],"advanced":[151],"characteristics":[152],"contribute":[156],"disease":[158],"diagnosis":[159],"relevant":[161],"treatment":[162],"clinical":[164],"applications.":[165]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}