{"id":"https://openalex.org/W2887777797","doi":"https://doi.org/10.1109/memea.2018.8438733","title":"Development and mechanical validation of an in vitro system for bone cell vibration loading","display_name":"Development and mechanical validation of an in vitro system for bone cell vibration loading","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2887777797","doi":"https://doi.org/10.1109/memea.2018.8438733","mag":"2887777797"},"language":"en","primary_location":{"id":"doi:10.1109/memea.2018.8438733","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2018.8438733","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086994002","display_name":"Ludovica Apa","orcid":"https://orcid.org/0000-0002-4249-5596"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Ludovica Apa","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, Sapienza, University of Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Sapienza, University of Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045012294","display_name":"Enrica Urciuoli","orcid":"https://orcid.org/0000-0002-9746-1668"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrica Urciuoli","raw_affiliation_strings":["Universita degli Studi di Roma La Sapienza, Roma, Lazio, IT"],"affiliations":[{"raw_affiliation_string":"Universita degli Studi di Roma La Sapienza, Roma, Lazio, IT","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047700448","display_name":"Livio D\u2019Alvia","orcid":"https://orcid.org/0000-0003-2952-5655"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Livio D'Alvia","raw_affiliation_strings":["Sapienza University of Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Sapienza University of Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047968877","display_name":"Barbara Peruzzi","orcid":"https://orcid.org/0000-0003-1820-5816"},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Peruzzi","raw_affiliation_strings":["Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children\u2019s Hospital, IRCCS, Rome, Italy","Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children\u2019s Hospital, IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016949200","display_name":"Zaccaria Del Prete","orcid":"https://orcid.org/0000-0001-6057-7774"},"institutions":[{"id":"https://openalex.org/I4210102151","display_name":"Santa Maria Nuova Hospital","ror":"https://ror.org/01cyv3m84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210102151"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Zaccaria Del Prete","raw_affiliation_strings":["Arcispedale Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Emilia-Romagna, IT","Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children\u2019s Hospital, IRCCS, Rome, Italy","Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Arcispedale Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Emilia-Romagna, IT","institution_ids":["https://openalex.org/I4210102151"]},{"raw_affiliation_string":"Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children\u2019s Hospital, IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064007911","display_name":"Emanuele Rizzuto","orcid":"https://orcid.org/0000-0003-2314-6128"},"institutions":[{"id":"https://openalex.org/I4210102151","display_name":"Santa Maria Nuova Hospital","ror":"https://ror.org/01cyv3m84","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210102151"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuele Rizzuto","raw_affiliation_strings":["Arcispedale Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Emilia-Romagna, IT","Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children\u2019s Hospital, IRCCS, Rome, Italy","Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Arcispedale Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Emilia-Romagna, IT","institution_ids":["https://openalex.org/I4210102151"]},{"raw_affiliation_string":"Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children\u2019s Hospital, IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5086994002"],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":0.109,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.44455853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vibration","display_name":"Vibration","score":0.7553112506866455},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"Mechanotransduction","score":0.7196729183197021},{"id":"https://openalex.org/keywords/repeatability","display_name":"Repeatability","score":0.6033207774162292},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5571973919868469},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5085436105728149},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.46080920100212097},{"id":"https://openalex.org/keywords/amplitude","display_name":"Amplitude","score":0.4402669072151184},{"id":"https://openalex.org/keywords/dispersion","display_name":"Dispersion (optics)","score":0.4384618401527405},{"id":"https://openalex.org/keywords/structural-engineering","display_name":"Structural engineering","score":0.36927998065948486},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.354050874710083},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3377971947193146},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.27106773853302},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2296045422554016},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.19040849804878235},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1726386845111847},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.13775885105133057}],"concepts":[{"id":"https://openalex.org/C198394728","wikidata":"https://www.wikidata.org/wiki/Q3695508","display_name":"Vibration","level":2,"score":0.7553112506866455},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.7196729183197021},{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.6033207774162292},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5571973919868469},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5085436105728149},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.46080920100212097},{"id":"https://openalex.org/C180205008","wikidata":"https://www.wikidata.org/wiki/Q159190","display_name":"Amplitude","level":2,"score":0.4402669072151184},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.4384618401527405},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.36927998065948486},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.354050874710083},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3377971947193146},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27106773853302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2296045422554016},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19040849804878235},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1726386845111847},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13775885105133057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/memea.2018.8438733","is_oa":false,"landing_page_url":"https://doi.org/10.1109/memea.2018.8438733","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1137700","is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1137700","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W282950450","https://openalex.org/W1756833589","https://openalex.org/W1784155883","https://openalex.org/W1875886495","https://openalex.org/W1909155825","https://openalex.org/W1969695594","https://openalex.org/W1969724199","https://openalex.org/W1976548401","https://openalex.org/W1977941731","https://openalex.org/W1985371035","https://openalex.org/W1999677246","https://openalex.org/W2002688520","https://openalex.org/W2010617850","https://openalex.org/W2011494353","https://openalex.org/W2013785685","https://openalex.org/W2024916097","https://openalex.org/W2025199445","https://openalex.org/W2034772940","https://openalex.org/W2045059538","https://openalex.org/W2048492086","https://openalex.org/W2060608295","https://openalex.org/W2062966761","https://openalex.org/W2116672717","https://openalex.org/W2120235049","https://openalex.org/W2130143727","https://openalex.org/W2146876476","https://openalex.org/W2158144686","https://openalex.org/W2171705946","https://openalex.org/W2223712442","https://openalex.org/W2296975830"],"related_works":["https://openalex.org/W2774752550","https://openalex.org/W4288084846","https://openalex.org/W2893816048","https://openalex.org/W3168747143","https://openalex.org/W2315867670","https://openalex.org/W1968795594","https://openalex.org/W2237675924","https://openalex.org/W2755432716","https://openalex.org/W2001085980","https://openalex.org/W1605170656"],"abstract_inverted_index":{"Vibration":[0],"loading,":[1],"both":[2],"low":[3,128],"magnitude":[4,7,96,261],"and":[5,37,79,101,104,110,127,172,262,264],"high":[6,9,126,131],"at":[8,92,130,318],"frequency,":[10,308],"has":[11],"been":[12],"demonstrated":[13],"to":[14,62,77,87,121,125,154,157,210,248],"have":[15],"an":[16,56],"anabolic":[17],"effect":[18],"on":[19,162,220],"bone":[20,139],"cells.":[21],"The":[22,53,71,142,175,216],"study":[23,75,122],"of":[24,48,55,73,95,138,149,187,192,194,234,257,260,316],"the":[25,27,46,64,68,147,150,155,159,179,188,202,212,225,241,244,265,272,285,295,301],"mechanotransduction,":[26],"process":[28],"by":[29,35,274,289],"which":[30],"mechanical":[31,143,242],"loadings":[32],"are":[33],"detected":[34],"cells":[36,252],"converted":[38],"in":[39,49,57,67,167,178,201,284,300],"chemical":[40],"signal,":[41],"is":[42,61,146],"made":[43],"accessible":[44],"through":[45],"use":[47],"vitro":[50,58],"loading":[51,59,84,152,256],"system.":[52],"aim":[54],"system":[60,85,114,156,245],"recreate":[63],"forces":[65],"acting":[66],"cell":[69,123,140,163,266,275],"microenvironment.":[70],"goal":[72],"this":[74,116],"was":[76,165,208,246,268],"develop":[78],"mechanically":[80],"validate":[81],"a":[82,135,183,205,229],"vibration":[83,91,217,255,292],"able":[86],"engender":[88],"sinusoidal":[89],"vertical":[90],"different":[93,169],"combinations":[94,259],"(0.3":[97],"g,":[98],"1":[99],"g":[100,315],"3":[102],"g)":[103],"frequency":[105,263],"(30":[106],"Hz,":[107],"60":[108],"Hz":[109,291],"90":[111,290],"Hz).":[112],"A":[113],"like":[115,251],"can":[117],"be":[118],"therefore":[119],"employed":[120],"response":[124],"magnitudes":[129],"frequencies,":[132],"thus":[133],"providing":[134],"comprehensive":[136],"evaluation":[137],"mechanotransduction.":[141],"validation,":[144,243],"that":[145,281],"characterization":[148],"right":[151],"input":[153],"obtain":[158],"desired":[160],"stimulation":[161,307],"culture,":[164],"performed":[166],"two":[168],"methods:":[170],"open-loop":[171,180],"closed-loop":[173,203],"mode.":[174],"results":[176,279],"obtained":[177],"mode":[181,204],"showed":[182,228,280],"good":[184,230],"intra-day":[185],"repeatability":[186],"measurements":[189],"with":[190,232,254],"values":[191],"index":[193,233],"dispersion":[195,235],"always":[196,236],"lower":[197,237,306],"than":[198,238],"0.6%.":[199],"While":[200],"systematic":[206,226],"search":[207,227],"implemented":[209],"reach":[211],"optimal":[213],"amplitude":[214,317],"stimulation.":[215],"signals":[218],"acquired":[219],"long":[221],"term":[222],"test":[223],"following":[224],"stability":[231],"1%.":[239],"Following":[240],"used":[247],"stimulate":[249],"osteoblast":[250],"(Saos-2)":[253],"nine":[258],"proliferation":[267,286,302],"studied":[269],"24h":[270],"after":[271],"treatment":[273],"counting.":[276],"Our":[277],"preliminary":[278],"no":[282],"alterations":[283],"were":[287,303],"induced":[288],"loading.":[293],"On":[294],"other":[296],"hand,":[297],"small":[298],"modulations":[299],"reported":[304],"for":[305],"being":[309],"statistically":[310],"significant":[311],"when":[312],"using":[313],"0.3":[314],"30":[319],"Hz.":[320]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}