{"id":"https://openalex.org/W4413112403","doi":"https://doi.org/10.1109/jbhi.2025.3597855","title":"Minimizing Sensory Habituation in Nerve Stimulation Through Strategic Temporal Stimulation Patterns","display_name":"Minimizing Sensory Habituation in Nerve Stimulation Through Strategic Temporal Stimulation Patterns","publication_year":2025,"publication_date":"2025-08-12","ids":{"openalex":"https://openalex.org/W4413112403","doi":"https://doi.org/10.1109/jbhi.2025.3597855","pmid":"https://pubmed.ncbi.nlm.nih.gov/40794499"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2025.3597855","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3597855","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018173166","display_name":"Susan Coltman","orcid":"https://orcid.org/0000-0002-3113-0911"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan K. Coltman","raw_affiliation_strings":["Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3113-0911","affiliations":[{"raw_affiliation_string":"Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050076687","display_name":"Xiaogang Hu","orcid":"https://orcid.org/0000-0002-8565-5940"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaogang Hu","raw_affiliation_strings":["Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA","Department of Kinesiology, Department of Mechanical Engineering, Department of Physical Medicine and Rehabilitation, the Huck Institutes of the Life Sciences, and the Center for Neural Engineering, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8565-5940","affiliations":[{"raw_affiliation_string":"Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Kinesiology, Department of Mechanical Engineering, Department of Physical Medicine and Rehabilitation, the Huck Institutes of the Life Sciences, and the Center for Neural Engineering, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018173166"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":null,"apc_paid":null,"fwci":1.6153,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.83979078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"30","issue":"3","first_page":"2646","last_page":"2655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/habituation","display_name":"Habituation","score":0.8157749772071838},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.7617441415786743},{"id":"https://openalex.org/keywords/sensory-system","display_name":"Sensory system","score":0.7144765257835388},{"id":"https://openalex.org/keywords/sensation","display_name":"Sensation","score":0.47296518087387085},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4679352939128876},{"id":"https://openalex.org/keywords/ulnar-nerve","display_name":"Ulnar nerve","score":0.46590644121170044},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4124097526073456},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3945622444152832},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.3790301978588104},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.3543512523174286},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.22938448190689087},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.22112935781478882},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.19924712181091309}],"concepts":[{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.8157749772071838},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7617441415786743},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.7144765257835388},{"id":"https://openalex.org/C130093455","wikidata":"https://www.wikidata.org/wiki/Q173253","display_name":"Sensation","level":2,"score":0.47296518087387085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4679352939128876},{"id":"https://openalex.org/C2778931672","wikidata":"https://www.wikidata.org/wiki/Q254580","display_name":"Ulnar nerve","level":3,"score":0.46590644121170044},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4124097526073456},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3945622444152832},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3790301978588104},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3543512523174286},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22938448190689087},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.22112935781478882},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19924712181091309},{"id":"https://openalex.org/C2781184374","wikidata":"https://www.wikidata.org/wiki/Q42586","display_name":"Elbow","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004561","descriptor_name":"Transcutaneous Electric Nerve Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004561","descriptor_name":"Transcutaneous Electric Nerve Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006185","descriptor_name":"Habituation, Psychophysiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006185","descriptor_name":"Habituation, Psychophysiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008475","descriptor_name":"Median Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008475","descriptor_name":"Median Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014459","descriptor_name":"Ulnar Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014459","descriptor_name":"Ulnar Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056228","descriptor_name":"Feedback, Sensory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D056228","descriptor_name":"Feedback, Sensory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2025.3597855","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2025.3597855","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:40794499","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40794499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1333651316","display_name":null,"funder_award_id":"IIS-2330862","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1851878861","display_name":null,"funder_award_id":"CBET-1847319","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8817733548","display_name":null,"funder_award_id":"IIS-2319139","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W2078511678","https://openalex.org/W2085313189","https://openalex.org/W2108068079","https://openalex.org/W2128485631","https://openalex.org/W2131220353","https://openalex.org/W2132855977","https://openalex.org/W2154683138","https://openalex.org/W2323855596","https://openalex.org/W2415521922","https://openalex.org/W2591130756","https://openalex.org/W2612402576","https://openalex.org/W2751515399","https://openalex.org/W2775487972","https://openalex.org/W2790194079","https://openalex.org/W2796496693","https://openalex.org/W2799988055","https://openalex.org/W2802163791","https://openalex.org/W2809670021","https://openalex.org/W2914011036","https://openalex.org/W2934221225","https://openalex.org/W2981110094","https://openalex.org/W3020272814","https://openalex.org/W3032409589","https://openalex.org/W3036967207","https://openalex.org/W3137083149","https://openalex.org/W3155459584","https://openalex.org/W3174015231","https://openalex.org/W3208293247","https://openalex.org/W4281750772","https://openalex.org/W4292421478","https://openalex.org/W4312081563","https://openalex.org/W4318766170","https://openalex.org/W4376254062","https://openalex.org/W4385454928","https://openalex.org/W4386050401","https://openalex.org/W4386603318","https://openalex.org/W4387047849","https://openalex.org/W4392558171","https://openalex.org/W4401567525","https://openalex.org/W4401642802","https://openalex.org/W4403867307","https://openalex.org/W4405894797"],"related_works":["https://openalex.org/W1974089501","https://openalex.org/W2611753819","https://openalex.org/W2088977183","https://openalex.org/W2132921858","https://openalex.org/W2052143611","https://openalex.org/W2018610517","https://openalex.org/W1979572287","https://openalex.org/W2462223799","https://openalex.org/W2996881974","https://openalex.org/W4229774776"],"abstract_inverted_index":{"Transcutaneous":[0],"nerve":[1,49,147,159],"stimulation":[2,29,50,79,84,142,189],"(TNS)":[3],"has":[4],"the":[5,27,61,104,117,124,145,157,178,200],"potential":[6,179],"to":[7,40,141,152,180],"restore":[8],"sensory":[9,93,172,206],"feedback":[10,173,207],"in":[11,26,73,174,209],"upper-limb":[12],"prosthetic":[13],"users.":[14],"However,":[15],"its":[16],"effectiveness":[17],"is":[18,23],"limited":[19],"by":[20],"habituation,":[21],"which":[22,191],"a":[24,52,65,109,166],"reduction":[25],"perceived":[28],"intensity":[30],"with":[31,144,156,177],"prolonged":[32],"use.":[33],"This":[34],"study":[35],"investigated":[36],"TNS":[37],"parameter":[38,153],"optimization":[39],"maintain":[41],"consistent":[42],"sensation,":[43],"focusing":[44],"on":[45,60],"median":[46,146],"and":[47,78,127,184,195],"ulnar":[48,158],"through":[51],"high-density":[53],"2":[54],"\u00d7":[55],"5":[56],"electrode":[57],"grid":[58],"positioned":[59],"upper":[62],"arm.":[63],"Through":[64],"systematic":[66],"evaluation":[67],"of":[68],"six":[69],"experimental":[70],"conditions":[71],"varying":[72],"block":[74],"duration,":[75],"rest":[76,197],"intervals,":[77,198],"patterns,":[80],"we":[81,137],"identified":[82,188],"optimal":[83],"parameters":[85],"that":[86],"significantly":[87,129,149],"reduced":[88],"habituation":[89],"while":[90,107],"maintaining":[91,108,170],"robust":[92],"feedback.":[94],"The":[95,187],"most":[96],"effective":[97,204],"protocol":[98,106],"demonstrated":[99],"37.87%":[100],"higher":[101],"sensitivity":[102,151],"than":[103],"standard":[105],"low":[110],"decay":[111],"rate":[112],"(0.09":[113],"$\\pm$":[114],"0.02).":[115],"During":[116],"main":[118],"protocol,":[119],"force":[120],"output":[121],"stabilized":[122],"after":[123],"initial":[125],"adaptation":[126],"remained":[128],"above":[130],"baseline":[131],"(p":[132,160],"$<":[133],"$":[134],"0.0001).":[135],"Notably,":[136],"observed":[138],"nerve-specific":[139],"responses":[140],"parameters,":[143],"showing":[148],"heightened":[150],"variations":[154],"compared":[155],"=":[161],"0.0267).":[162],"These":[163],"findings":[164],"offer":[165],"promising":[167],"approach":[168],"for":[169,202],"stable":[171],"neuroprosthetic":[175],"applications,":[176],"improve":[181],"user":[182],"experience":[183],"device":[185],"adoption.":[186],"condition,":[190],"features":[192],"1-minute":[193],"blocks":[194],"strategic":[196],"lays":[199],"groundwork":[201],"more":[203],"TNS-based":[205],"systems":[208],"clinical":[210],"applications.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-03-09T07:00:12.390032","created_date":"2025-10-10T00:00:00"}
