{"id":"https://openalex.org/W4416962825","doi":"https://doi.org/10.1109/ist66504.2025.11268366","title":"Viscosity Prediction for Tumor Microenvironments via spin-exchange relaxation-free magnetorelaxometry of Magnetic Nanoparticles","display_name":"Viscosity Prediction for Tumor Microenvironments via spin-exchange relaxation-free magnetorelaxometry of Magnetic Nanoparticles","publication_year":2025,"publication_date":"2025-10-15","ids":{"openalex":"https://openalex.org/W4416962825","doi":"https://doi.org/10.1109/ist66504.2025.11268366"},"language":null,"primary_location":{"id":"doi:10.1109/ist66504.2025.11268366","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ist66504.2025.11268366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Imaging Systems and Techniques (IST)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100386475","display_name":"Xiaoyu Chen","orcid":"https://orcid.org/0000-0001-6256-9321"},"institutions":[{"id":"https://openalex.org/I4210139061","display_name":"Zero Emissions Resource Organisation","ror":"https://ror.org/03j5ebv52","country_code":"NO","type":"nonprofit","lineage":["https://openalex.org/I4210139061"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Xiaoyu Chen","raw_affiliation_strings":["Beihang University,Institute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science,Hangzhou,China"],"affiliations":[{"raw_affiliation_string":"Beihang University,Institute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science,Hangzhou,China","institution_ids":["https://openalex.org/I4210139061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054372750","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0001-8608-3035"},"institutions":[{"id":"https://openalex.org/I4210139061","display_name":"Zero Emissions Resource Organisation","ror":"https://ror.org/03j5ebv52","country_code":"NO","type":"nonprofit","lineage":["https://openalex.org/I4210139061"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Huangliang Wu","raw_affiliation_strings":["Beihang University,Institute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science,Hangzhou,China"],"affiliations":[{"raw_affiliation_string":"Beihang University,Institute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science,Hangzhou,China","institution_ids":["https://openalex.org/I4210139061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077797048","display_name":"Yanfei Meng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142646","display_name":"Extreme Light Infrastructure - Nuclear Physics","ror":"https://ror.org/048m5jb39","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210142646"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Yanfei Meng","raw_affiliation_strings":["Hangzhou Institute of National Extremely-Weak Magnetic Field Infrastructure,Hangzhou,China"],"affiliations":[{"raw_affiliation_string":"Hangzhou Institute of National Extremely-Weak Magnetic Field Infrastructure,Hangzhou,China","institution_ids":["https://openalex.org/I4210142646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052839231","display_name":"Xianhong Li","orcid":"https://orcid.org/0000-0003-4063-4131"},"institutions":[{"id":"https://openalex.org/I4210142646","display_name":"Extreme Light Infrastructure - Nuclear Physics","ror":"https://ror.org/048m5jb39","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210142646"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Xianhong Li","raw_affiliation_strings":["Hangzhou Institute of National Extremely-Weak Magnetic Field Infrastructure,Hangzhou,China"],"affiliations":[{"raw_affiliation_string":"Hangzhou Institute of National Extremely-Weak Magnetic Field Infrastructure,Hangzhou,China","institution_ids":["https://openalex.org/I4210142646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033339574","display_name":"Chunyi Liu","orcid":"https://orcid.org/0009-0005-7030-0310"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyi Liu","raw_affiliation_strings":["Nanjing University,Medical School,Nanjing,China"],"affiliations":[{"raw_affiliation_string":"Nanjing University,Medical School,Nanjing,China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045338934","display_name":"Jingyi Sheng","orcid":null},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Sheng","raw_affiliation_strings":["Southeast University,Jiangsu Key Laboratory for Biomaterials and Devices, School of Biomedical Engineering,Nanjing,China"],"affiliations":[{"raw_affiliation_string":"Southeast University,Jiangsu Key Laboratory for Biomaterials and Devices, School of Biomedical Engineering,Nanjing,China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101988835","display_name":"Xu Zhang","orcid":"https://orcid.org/0000-0002-6520-1917"},"institutions":[{"id":"https://openalex.org/I4210102600","display_name":"High Magnetic Field Laboratory","ror":"https://ror.org/01gh88804","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667","https://openalex.org/I4210102600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zhang","raw_affiliation_strings":["Beihang University Hangzhou Institute of National Extremely-Weak Magnetic Field Infrastructure,The Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology Ministry of Education, School of Instrumentation and Optoelectronic Engineering,Hangzhou,China"],"affiliations":[{"raw_affiliation_string":"Beihang University Hangzhou Institute of National Extremely-Weak Magnetic Field Infrastructure,The Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology Ministry of Education, School of Instrumentation and Optoelectronic Engineering,Hangzhou,China","institution_ids":["https://openalex.org/I4210102600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109126673","display_name":"Ning Gu","orcid":null},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Gu","raw_affiliation_strings":["Southeast University Nanjing,Jiangsu Key Laboratory for Biomaterials and Devices, School of Biomedical Engineering"],"affiliations":[{"raw_affiliation_string":"Southeast University Nanjing,Jiangsu Key Laboratory for Biomaterials and Devices, School of Biomedical Engineering","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071836863","display_name":"Min Xiang","orcid":"https://orcid.org/0000-0002-0239-3392"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Xiang","raw_affiliation_strings":["Nanjing University,Key Laboratory for Cardiovascular Medical School,Nanjing,China"],"affiliations":[{"raw_affiliation_string":"Nanjing University,Key Laboratory for Cardiovascular Medical School,Nanjing,China","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100386475"],"corresponding_institution_ids":["https://openalex.org/I4210139061"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36434099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.8223999738693237,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.8223999738693237,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relaxation","display_name":"Relaxation (psychology)","score":0.6843000054359436},{"id":"https://openalex.org/keywords/viscosity","display_name":"Viscosity","score":0.6830999851226807},{"id":"https://openalex.org/keywords/magnetic-nanoparticles","display_name":"Magnetic nanoparticles","score":0.6116999983787537},{"id":"https://openalex.org/keywords/superparamagnetism","display_name":"Superparamagnetism","score":0.6003000140190125},{"id":"https://openalex.org/keywords/magnetic-relaxation","display_name":"Magnetic relaxation","score":0.558899998664856},{"id":"https://openalex.org/keywords/brownian-motion","display_name":"Brownian motion","score":0.5181000232696533},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.49320000410079956},{"id":"https://openalex.org/keywords/magnetization","display_name":"Magnetization","score":0.4368000030517578}],"concepts":[{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.6843000054359436},{"id":"https://openalex.org/C127172972","wikidata":"https://www.wikidata.org/wiki/Q128709","display_name":"Viscosity","level":2,"score":0.6830999851226807},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.6116999983787537},{"id":"https://openalex.org/C23792430","wikidata":"https://www.wikidata.org/wiki/Q1122780","display_name":"Superparamagnetism","level":4,"score":0.6003000140190125},{"id":"https://openalex.org/C2986117127","wikidata":"https://www.wikidata.org/wiki/Q900475","display_name":"Magnetic relaxation","level":4,"score":0.558899998664856},{"id":"https://openalex.org/C112401455","wikidata":"https://www.wikidata.org/wiki/Q178036","display_name":"Brownian motion","level":2,"score":0.5181000232696533},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5135999917984009},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.49320000410079956},{"id":"https://openalex.org/C32546565","wikidata":"https://www.wikidata.org/wiki/Q856711","display_name":"Magnetization","level":3,"score":0.4368000030517578},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3995000123977661},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.38109999895095825},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.37929999828338623},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3149000108242035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.298799991607666},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C78902741","wikidata":"https://www.wikidata.org/wiki/Q4915071","display_name":"Biomagnetism","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C130603088","wikidata":"https://www.wikidata.org/wiki/Q4976526","display_name":"Brownian dynamics","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C83581075","wikidata":"https://www.wikidata.org/wiki/Q1361503","display_name":"Excitation","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C2113261","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Extracellular fluid","level":3,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ist66504.2025.11268366","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ist66504.2025.11268366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Imaging Systems and Techniques (IST)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1850225302","https://openalex.org/W1983277479","https://openalex.org/W2593053430","https://openalex.org/W2784509718","https://openalex.org/W2805745243","https://openalex.org/W2883424472","https://openalex.org/W2920832895","https://openalex.org/W3036745092","https://openalex.org/W4285261587","https://openalex.org/W4293717074","https://openalex.org/W4307931636","https://openalex.org/W4367359654","https://openalex.org/W4367721793","https://openalex.org/W4399143410","https://openalex.org/W4401658734"],"related_works":[],"abstract_inverted_index":{"The":[0,63,140],"elevated":[1],"viscosity":[2,32,127],"of":[3,59,82,129],"tumour":[4,25,164],"extracellular":[5],"fluid":[6,149],"plays":[7],"a":[8,20,47,75,95,108,126,159],"critical":[9],"role":[10],"in":[11,33,74,171],"enhancing":[12],"cancer":[13,173],"cell":[14],"migration":[15],"and":[16,70,144,151,167,175],"invasion,":[17],"making":[18],"it":[19],"key":[21],"physical":[22],"marker":[23],"for":[24,30,162],"progression.":[26],"However,":[27],"existing":[28],"methods":[29],"measuring":[31],"biological":[34],"systems":[35],"often":[36],"lack":[37],"sensitivity,":[38],"continuity,":[39],"or":[40],"non-invasiveness.":[41],"In":[42],"this":[43],"work,":[44],"we":[45,98],"introduce":[46],"spin-exchange":[48],"relaxation-free":[49],"magnetorelaxometry":[50],"(SERF-MRX)":[51],"technique":[52],"based":[53],"on":[54,116],"the":[55,89,100],"Brownian":[56],"relaxation":[57,72,90,102,123,152],"behavior":[58],"superparamagnetic":[60],"nanoparticles":[61],"(MNPs).":[62],"system":[64],"applies":[65],"low-intensity":[66],"DC":[67],"magnetic":[68,77],"excitation":[69],"detects":[71],"signals":[73],"near-zero":[76],"field,":[78],"enabling":[79],"precise":[80],"capture":[81],"viscosity-dependent":[83],"magnetization":[84],"decay":[85],"$M(t)$.":[86],"By":[87],"modeling":[88],"time":[91,103],"distribution":[92],"$A(\\tau)$":[93],"with":[94],"log-normal":[96],"function,":[97],"extract":[99],"peak":[101],"$\\tau_{\\text":[104],"{peak":[105],"}}$":[106],"as":[107],"viscosity-sensitive":[109],"feature.":[110],"A":[111],"neural":[112],"network":[113],"is":[114],"trained":[115],"interpolated":[117],"spectral":[118],"data":[119],"to":[120],"predict":[121],"continuous":[122],"responses":[124],"across":[125],"range":[128],"$\\mathbf{1":[130],"-":[131],"2":[132],"0":[133],"~":[134],"m":[135],"P":[136],"a}":[137],"\\boldsymbol{\\cdot}":[138],"\\mathbf{s}$.":[139],"method":[141],"achieves":[142],"interpretable":[143],"physically":[145],"consistent":[146],"mapping":[147],"between":[148],"properties":[150],"dynamics.":[153],"This":[154],"compact,":[155],"interference-free":[156],"platform":[157],"provides":[158],"new":[160],"tool":[161],"probing":[163],"microenvironment":[165],"mechanics":[166],"offers":[168],"promising":[169],"potential":[170],"non-invasive":[172],"diagnostics":[174],"personalized":[176],"treatment":[177],"monitoring.":[178]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-12-03T00:00:00"}