{"id":"https://openalex.org/W1574197265","doi":"https://doi.org/10.1109/isbi.2015.7163894","title":"Automated monitoring of human embryonic cells up to the 5-cell stage in time-lapse microscopy images","display_name":"Automated monitoring of human embryonic cells up to the 5-cell stage in time-lapse microscopy images","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1574197265","doi":"https://doi.org/10.1109/isbi.2015.7163894","mag":"1574197265"},"language":"en","primary_location":{"id":"doi:10.1109/isbi.2015.7163894","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7163894","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105470976","display_name":"Aisha Khan","orcid":null},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Aisha Khan","raw_affiliation_strings":["College of Engineering and Computer Science, The Australian National University, Canberra, AU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering and Computer Science, The Australian National University, Canberra, AU","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071663279","display_name":"Stephen Jay Gould","orcid":"https://orcid.org/0000-0001-8929-7899"},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen Gould","raw_affiliation_strings":["College of Engineering and Computer Science, The Australian National University, Canberra, AU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering and Computer Science, The Australian National University, Canberra, AU","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049300388","display_name":"Mathieu Salzmann","orcid":"https://orcid.org/0000-0002-8347-8637"},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]},{"id":"https://openalex.org/I42894916","display_name":"Data61","ror":"https://ror.org/03q397159","country_code":"AU","type":"other","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I42894916","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mathieu Salzmann","raw_affiliation_strings":["College of Engineering and Computer Science, The Australian National University, Canberra, AU","NICTA, Computer Vision Research Group, Canberra, AU"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering and Computer Science, The Australian National University, Canberra, AU","institution_ids":["https://openalex.org/I118347636"]},{"raw_affiliation_string":"NICTA, Computer Vision Research Group, Canberra, AU","institution_ids":["https://openalex.org/I42894916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.5751,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.98642173,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"389","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11164","display_name":"Remote Sensing and LiDAR Applications","score":0.9251999855041504,"subfield":{"id":"https://openalex.org/subfields/2305","display_name":"Environmental Engineering"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.7236261963844299},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.6162991523742676},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5383999943733215},{"id":"https://openalex.org/keywords/in-vitro-fertilisation","display_name":"In vitro fertilisation","score":0.4952804148197174},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.41990742087364197},{"id":"https://openalex.org/keywords/stage","display_name":"Stage (stratigraphy)","score":0.4133709967136383},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4087224304676056},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4005556106567383},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36037737131118774},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34032291173934937},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1681535840034485},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07516375184059143}],"concepts":[{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7236261963844299},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6162991523742676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5383999943733215},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.4952804148197174},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.41990742087364197},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4133709967136383},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4087224304676056},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4005556106567383},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36037737131118774},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34032291173934937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1681535840034485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07516375184059143},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi.2015.7163894","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi.2015.7163894","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.672.1056","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.672.1056","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://users.cecs.anu.edu.au/%7Esgould/papers/isbi15-embryo.pdf","raw_type":"text"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/103317","is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/103317","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings - International Symposium on Biomedical Imaging","raw_type":"Conference paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1511986666","https://openalex.org/W1529291652","https://openalex.org/W1618905105","https://openalex.org/W1994766605","https://openalex.org/W2025570575","https://openalex.org/W2052320831","https://openalex.org/W2053729823","https://openalex.org/W2066729341","https://openalex.org/W2080018890","https://openalex.org/W2087069550","https://openalex.org/W2109784859","https://openalex.org/W2124381929","https://openalex.org/W2128871431","https://openalex.org/W2548695521","https://openalex.org/W6631807940","https://openalex.org/W6676424520","https://openalex.org/W6679078458"],"related_works":["https://openalex.org/W2320619678","https://openalex.org/W2329386257","https://openalex.org/W2503350049","https://openalex.org/W2394138874","https://openalex.org/W2397616145","https://openalex.org/W2027569400","https://openalex.org/W2417550541","https://openalex.org/W2397320258","https://openalex.org/W1966678537","https://openalex.org/W2381724992"],"abstract_inverted_index":{"Measurement":[0],"of":[1,5,38,109,142,150,163,170],"the":[2,39,48,76,84,93,107,118,143,148,161],"proliferative":[3],"behavior":[4],"human":[6,173],"embryonic":[7],"cells":[8,110,123,151],"in":[9,31,61,66,124],"vitro":[10,32],"is":[11],"important":[12],"to":[13,22,47,57,91],"many":[14],"biomedical":[15],"applications":[16],"ranging":[17],"from":[18],"basic":[19],"biology":[20,68],"research":[21,65],"advanced":[23],"applications,":[24],"such":[25],"as":[26],"determining":[27],"embryo":[28,40,52,81,119,145],"viability":[29],"during":[30],"fertilization":[33],"(IVF)":[34],"treatments.":[35],"Automated":[36],"prediction":[37],"viability,":[41],"by":[42],"tracking":[43,72],"cell":[44,67,73],"divisions":[45,74],"up":[46],"4-cell":[49,77],"stage,":[50],"improves":[51,80],"selection":[53],"and":[54,115,146],"may":[55],"lead":[56],"increased":[58],"success":[59],"rates":[60],"IVF":[62],"pregnancies.":[63],"Recent":[64],"has":[69],"suggested":[70],"that":[71,137],"beyond":[75,121],"stage":[78],"further":[79],"selection.":[82],"In":[83,101],"current":[85],"state-of-the-art,":[86],"later":[87],"events":[88],"(e.g.,":[89],"time":[90,113,154],"reach":[92],"5-cell":[94],"stage)":[95],"can":[96],"only":[97],"be":[98],"assessed":[99],"manually.":[100],"this":[102],"work":[103],"we":[104],"automatically":[105],"predict":[106,116],"number":[108,149],"at":[111,152],"every":[112],"point,":[114],"when":[117],"divides":[120],"four":[122],"a":[125,132,167],"time-lapse":[126],"microscopy":[127],"sequence.":[128],"Our":[129],"approach":[130],"employs":[131],"conditional":[133],"random":[134],"field":[135],"(CRF)":[136],"compactly":[138],"encodes":[139],"various":[140],"aspects":[141],"evolving":[144],"estimates":[147],"each":[153],"step":[155],"via":[156],"exact":[157],"inference.":[158],"We":[159],"demonstrate":[160],"effectiveness":[162],"our":[164],"method":[165],"on":[166],"data":[168],"set":[169],"33":[171],"developing":[172],"embryos.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}