{"id":"https://openalex.org/W2077621844","doi":"https://doi.org/10.1109/isb.2012.6314123","title":"Hierarchical modular structure in gene coexpression networks","display_name":"Hierarchical modular structure in gene coexpression networks","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2077621844","doi":"https://doi.org/10.1109/isb.2012.6314123","mag":"2077621844"},"language":"en","primary_location":{"id":"doi:10.1109/isb.2012.6314123","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isb.2012.6314123","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 6th International Conference on Systems Biology (ISB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024866341","display_name":"Shuqin Zhang","orcid":"https://orcid.org/0000-0001-8223-844X"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuqin Zhang","raw_affiliation_strings":["Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China","Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China"],"affiliations":[{"raw_affiliation_string":"Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Center for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024866341"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":null,"apc_paid":null,"fwci":0.42049483,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61091713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":null,"first_page":"118","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.8032764196395874},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6764380931854248},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6334755420684814},{"id":"https://openalex.org/keywords/hierarchical-database-model","display_name":"Hierarchical database model","score":0.5871501564979553},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.48328426480293274},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.48270487785339355},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4278404712677002},{"id":"https://openalex.org/keywords/hierarchical-control-system","display_name":"Hierarchical control system","score":0.42622435092926025},{"id":"https://openalex.org/keywords/community-structure","display_name":"Community structure","score":0.4214399755001068},{"id":"https://openalex.org/keywords/data-structure","display_name":"Data structure","score":0.42015668749809265},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3611365556716919},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1501263678073883},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.0742446780204773}],"concepts":[{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.8032764196395874},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6764380931854248},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6334755420684814},{"id":"https://openalex.org/C144986985","wikidata":"https://www.wikidata.org/wiki/Q871236","display_name":"Hierarchical database model","level":2,"score":0.5871501564979553},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.48328426480293274},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.48270487785339355},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4278404712677002},{"id":"https://openalex.org/C124527596","wikidata":"https://www.wikidata.org/wiki/Q17029359","display_name":"Hierarchical control system","level":3,"score":0.42622435092926025},{"id":"https://openalex.org/C133079900","wikidata":"https://www.wikidata.org/wiki/Q5155065","display_name":"Community structure","level":2,"score":0.4214399755001068},{"id":"https://openalex.org/C162319229","wikidata":"https://www.wikidata.org/wiki/Q175263","display_name":"Data structure","level":2,"score":0.42015668749809265},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3611365556716919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1501263678073883},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0742446780204773},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isb.2012.6314123","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isb.2012.6314123","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 6th International Conference on Systems Biology (ISB)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1969353942","https://openalex.org/W1970964234","https://openalex.org/W1971421925","https://openalex.org/W1976286767","https://openalex.org/W1995876521","https://openalex.org/W2015953751","https://openalex.org/W2017620474","https://openalex.org/W2017987256","https://openalex.org/W2021947606","https://openalex.org/W2034496052","https://openalex.org/W2038920443","https://openalex.org/W2057498577","https://openalex.org/W2060705109","https://openalex.org/W2061099285","https://openalex.org/W2064274783","https://openalex.org/W2086805702","https://openalex.org/W2089458547","https://openalex.org/W2091202730","https://openalex.org/W2100240966","https://openalex.org/W2103017472","https://openalex.org/W2108498827","https://openalex.org/W2118608338","https://openalex.org/W2120043163","https://openalex.org/W2127048411","https://openalex.org/W2128366083","https://openalex.org/W2151936673","https://openalex.org/W2168346701","https://openalex.org/W2171608649","https://openalex.org/W2399279838","https://openalex.org/W3101413764","https://openalex.org/W3102641634","https://openalex.org/W3105591082","https://openalex.org/W3123255541","https://openalex.org/W4312512934","https://openalex.org/W6640570641"],"related_works":["https://openalex.org/W2500657027","https://openalex.org/W178860912","https://openalex.org/W4206392734","https://openalex.org/W2077012825","https://openalex.org/W2028274662","https://openalex.org/W3043388626","https://openalex.org/W2731083674","https://openalex.org/W2338802643","https://openalex.org/W2079095842","https://openalex.org/W2116512232"],"abstract_inverted_index":{"Network":[0],"module":[1,19,40],"(community)":[2],"structure":[3,24,50,65,121],"has":[4],"been":[5,16],"a":[6,58,118],"hot":[7],"research":[8,44],"topic":[9],"in":[10,31,66],"recent":[11],"years.":[12],"Many":[13],"methods":[14],"have":[15,117],"proposed":[17,106],"for":[18,60],"detection":[20],"and":[21,92],"identification.":[22],"Hierarchical":[23],"of":[25,34,51,100,104],"modules":[26,124],"is":[27,45],"shown":[28],"to":[29,38,79,96,108,129],"exist":[30],"different":[32,85,126,130],"kinds":[33],"biological":[35],"networks.":[36],"Compared":[37],"the":[39,48,62,70,81,98,105,123],"identification":[41],"methods,":[42],"less":[43],"done":[46],"on":[47,69,125],"hierarchical":[49,63,82,119],"modules.":[52,86],"In":[53],"this":[54],"paper,":[55],"we":[56],"propose":[57],"method":[59,107],"constructing":[61],"modular":[64,120],"networks":[67,91],"based":[68],"extended":[71],"random":[72],"graph":[73],"model.":[74],"Statistical":[75],"tests":[76],"are":[77],"applied":[78],"test":[80],"relations":[83],"between":[84],"We":[87],"give":[88],"both":[89],"artificial":[90],"real":[93],"data":[94],"examples":[95],"illustrate":[97],"performance":[99],"our":[101],"approach.":[102],"Application":[103],"yeast":[109],"gene":[110,131],"co-expression":[111],"network":[112],"shows":[113],"that":[114],"it":[115],"does":[116],"with":[122],"levels":[127],"corresponding":[128],"functions.":[132]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}