{"id":"https://openalex.org/W2082100989","doi":"https://doi.org/10.1109/isb.2012.6314112","title":"Identifying novel glioma associated pathways based on integrated &amp;#x2018;omics&amp;#x2019; data","display_name":"Identifying novel glioma associated pathways based on integrated &amp;#x2018;omics&amp;#x2019; data","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2082100989","doi":"https://doi.org/10.1109/isb.2012.6314112","mag":"2082100989"},"language":"en","primary_location":{"id":"doi:10.1109/isb.2012.6314112","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isb.2012.6314112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 6th International Conference on Systems Biology (ISB)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084039281","display_name":"Yangfan Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yangfan Hu","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650441","display_name":"Jinquan Li","orcid":"https://orcid.org/0000-0001-8971-7582"},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinquan Li","raw_affiliation_strings":["The First Affiliated Hospital of Soochow University, China"],"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Soochow University, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400995","display_name":"Jiajia Chen","orcid":"https://orcid.org/0000-0002-1394-1657"},"institutions":[{"id":"https://openalex.org/I308837","display_name":"Suzhou University of Science and Technology","ror":"https://ror.org/04en8wb91","country_code":"CN","type":"education","lineage":["https://openalex.org/I308837"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Chen","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou, China","School of Chemistry and Biological Engineering, Suzhou University of Science and Technology, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"School of Chemistry and Biological Engineering, Suzhou University of Science and Technology, China","institution_ids":["https://openalex.org/I308837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101617943","display_name":"Guang Hu","orcid":"https://orcid.org/0000-0002-8754-1541"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang Hu","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081095213","display_name":"Bairong Shen","orcid":"https://orcid.org/0000-0003-2899-1531"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bairong Shen","raw_affiliation_strings":["Department of Bioinformatics, School of Medicine, Soochow University, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, School of Medicine, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084039281"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":null,"apc_paid":null,"fwci":0.1116,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56821378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":null,"first_page":"49","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.8028047680854797},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.6084709167480469},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5376208424568176},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.5292455554008484},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5244522094726562},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5122972726821899},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.4790560007095337},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4672273099422455},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44111618399620056},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4379955530166626},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.42348387837409973},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3206191658973694},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.25785762071609497},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19684606790542603}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8028047680854797},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6084709167480469},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5376208424568176},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.5292455554008484},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5244522094726562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5122972726821899},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4790560007095337},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4672273099422455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44111618399620056},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4379955530166626},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.42348387837409973},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3206191658973694},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25785762071609497},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19684606790542603}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isb.2012.6314112","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isb.2012.6314112","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 6th International Conference on Systems Biology (ISB)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5899999737739563,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W187263029","https://openalex.org/W1648301895","https://openalex.org/W1967042873","https://openalex.org/W1976625175","https://openalex.org/W1986052421","https://openalex.org/W1986397115","https://openalex.org/W1997733964","https://openalex.org/W2000040240","https://openalex.org/W2002995168","https://openalex.org/W2007587510","https://openalex.org/W2020046473","https://openalex.org/W2029669343","https://openalex.org/W2035769168","https://openalex.org/W2040191060","https://openalex.org/W2055632365","https://openalex.org/W2064988479","https://openalex.org/W2079487111","https://openalex.org/W2081436697","https://openalex.org/W2081758137","https://openalex.org/W2088170612","https://openalex.org/W2092068538","https://openalex.org/W2094253263","https://openalex.org/W2104865962","https://openalex.org/W2109044536","https://openalex.org/W2124201592","https://openalex.org/W2129795133","https://openalex.org/W2130410032","https://openalex.org/W2131093545","https://openalex.org/W2132023025","https://openalex.org/W2133971386","https://openalex.org/W2137224863","https://openalex.org/W2150638747","https://openalex.org/W2157132621","https://openalex.org/W2158017189","https://openalex.org/W2160679814","https://openalex.org/W2164687768","https://openalex.org/W2165541679","https://openalex.org/W2167119716","https://openalex.org/W2169869175","https://openalex.org/W2171808845","https://openalex.org/W6607565329"],"related_works":["https://openalex.org/W1996185163","https://openalex.org/W170658859","https://openalex.org/W2081127504","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W3023720143","https://openalex.org/W2183420549","https://openalex.org/W2081507994","https://openalex.org/W1972696957","https://openalex.org/W1986892844"],"abstract_inverted_index":{"Microarray":[0],"represents":[1],"a":[2],"high":[3],"throughput":[4],"technology":[5],"for":[6,135],"analyzing":[7],"expression":[8,78,130],"profiles,":[9],"and":[10,80,88,98,107,132,196],"thus":[11],"it":[12,39],"has":[13],"been":[14,65],"widely":[15],"applied":[16],"in":[17,36],"the":[18,27,32,44,82,110,142],"study":[19],"of":[20,22,26,57,84,95,109,116,145,174,180,186],"pathogenesis":[21],"glioma.":[23,37],"However,":[24],"most":[25],"analyses":[28],"focused":[29],"on":[30,74,125,194],"detecting":[31],"differentially":[33],"expressed":[34],"genes":[35,117],"Although":[38],"is":[40,47],"well":[41],"accepted":[42],"that":[43,51,105,115,141],"pathway-derived":[45],"signatures":[46,144],"more":[48,150],"reproducible":[49],"than":[50,114,155],"at":[52,61,86,152,156],"gene":[53,87,157],"level,":[54],"few":[55],"meta-analyses":[56],"multiple":[58],"microarray":[59],"datasets":[60],"system":[62],"level":[63,154],"have":[64],"previously":[66],"performed.":[67],"In":[68],"this":[69],"article,":[70],"we":[71,120],"performed":[72],"meta-analysis":[73],"different":[75,146],"published":[76],"glioma":[77,195],"profiles":[79,131],"compared":[81],"overlapping":[83],"signature":[85],"pathway":[89,153],"level.":[90,158],"Pathway":[91],"enrichment":[92],"analysis":[93],"result":[94],"GeneGO":[96,163],"database":[97,164],"Gene":[99],"Set":[100],"Enrichment":[101],"Analysis":[102],"(GSEA)":[103],"showed":[104,140],"100%":[106],"64%":[108],"similarity":[111],"was":[112],"higher":[113],"respectively.":[118],"Moreover,":[119],"integrated":[121],"other":[122],"omics":[123],"data":[124,147],"glioma,":[126],"such":[127,177],"as":[128,178],"MicroRNA":[129],"Chip-Seq":[133],"data,":[134],"further":[136,198],"verification.":[137,200],"The":[138],"results":[139],"significant":[143],"sets":[148],"are":[149],"similar":[151],"12":[159],"pathways":[160,193],"found":[161],"by":[162,167],"were":[165,190],"shared":[166],"four":[168],"stages":[169],"among":[170],"several":[171],"datasets.":[172],"5":[173],"these":[175],"pathways,":[176],"Regulation":[179],"epithelial-to-mesenchymal":[181],"transition":[182],"(EMT),":[183],"TGF-beta-dependent":[184],"induction":[185],"EMT":[187],"via":[188],"SMADs,":[189],"putative":[191],"novel":[192],"need":[197],"experimental":[199]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
