{"id":"https://openalex.org/W1494310228","doi":"https://doi.org/10.1109/ijcnn.2005.1556425","title":"Application of polymer microstructures with controlled surface chemistries as a platform for creating and interfacing with synthetic neural networks","display_name":"Application of polymer microstructures with controlled surface chemistries as a platform for creating and interfacing with synthetic neural networks","publication_year":2006,"publication_date":"2006-01-05","ids":{"openalex":"https://openalex.org/W1494310228","doi":"https://doi.org/10.1109/ijcnn.2005.1556425","mag":"1494310228"},"language":"en","primary_location":{"id":"doi:10.1109/ijcnn.2005.1556425","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2005.1556425","pdf_url":null,"source":{"id":"https://openalex.org/S4363609022","display_name":"Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109187330","display_name":"Geoff Mealing","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210096059","display_name":"Institute for Biological Sciences","ror":"https://ror.org/00t7c0489","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096059","https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"G. Mealing","raw_affiliation_strings":["Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778","https://openalex.org/I4210096059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065021949","display_name":"Mahmud Bani\u2010Yaghoub","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210096059","display_name":"Institute for Biological Sciences","ror":"https://ror.org/00t7c0489","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096059","https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Bani-Yaghoub","raw_affiliation_strings":["Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778","https://openalex.org/I4210096059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027704126","display_name":"Roger Tremblay","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096059","display_name":"Institute for Biological Sciences","ror":"https://ror.org/00t7c0489","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096059","https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Tremblay","raw_affiliation_strings":["Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778","https://openalex.org/I4210096059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041900193","display_name":"Robert Monette","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096059","display_name":"Institute for Biological Sciences","ror":"https://ror.org/00t7c0489","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096059","https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Monette","raw_affiliation_strings":["Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778","https://openalex.org/I4210096059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017431210","display_name":"John G. Mielke","orcid":"https://orcid.org/0000-0002-2151-9691"},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210096059","display_name":"Institute for Biological Sciences","ror":"https://ror.org/00t7c0489","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096059","https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Mielke","raw_affiliation_strings":["Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778","https://openalex.org/I4210096059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070635085","display_name":"Raluca Voicu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210130650","display_name":"Institute for Microstructural Sciences","ror":"https://ror.org/03v7h1165","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Voicu","raw_affiliation_strings":["Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111645444","display_name":"Christophe Py","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130650","display_name":"Institute for Microstructural Sciences","ror":"https://ror.org/03v7h1165","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. Py","raw_affiliation_strings":["Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052381701","display_name":"Raluca Barjovanu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210130650","display_name":"Institute for Microstructural Sciences","ror":"https://ror.org/03v7h1165","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Barjovanu","raw_affiliation_strings":["Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048355683","display_name":"Karim Fa\u00efd","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130650","display_name":"Institute for Microstructural Sciences","ror":"https://ror.org/03v7h1165","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]},{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K. Faid","raw_affiliation_strings":["Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada"],"affiliations":[{"raw_affiliation_string":"Organic Materials and Devices, Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Canada","institution_ids":["https://openalex.org/I4210130650","https://openalex.org/I4210159778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5109187330"],"corresponding_institution_ids":["https://openalex.org/I4210096059","https://openalex.org/I4210159778"],"apc_list":null,"apc_paid":null,"fwci":3.6129,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.83783784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":null,"first_page":"3116","last_page":"3120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interfacing","display_name":"Interfacing","score":0.7585916519165039},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.6034761667251587},{"id":"https://openalex.org/keywords/microscale-chemistry","display_name":"Microscale chemistry","score":0.5894336700439453},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5516100525856018},{"id":"https://openalex.org/keywords/neural-cell","display_name":"Neural cell","score":0.4574529230594635},{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.4405099153518677},{"id":"https://openalex.org/keywords/lithography","display_name":"Lithography","score":0.43417638540267944},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38421040773391724},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.24438077211380005},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.16444095969200134},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.14074298739433289},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.12306609749794006},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.11124062538146973}],"concepts":[{"id":"https://openalex.org/C2776303644","wikidata":"https://www.wikidata.org/wiki/Q1020499","display_name":"Interfacing","level":2,"score":0.7585916519165039},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6034761667251587},{"id":"https://openalex.org/C179428855","wikidata":"https://www.wikidata.org/wiki/Q1069216","display_name":"Microscale chemistry","level":2,"score":0.5894336700439453},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5516100525856018},{"id":"https://openalex.org/C2992459734","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neural cell","level":3,"score":0.4574529230594635},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.4405099153518677},{"id":"https://openalex.org/C204223013","wikidata":"https://www.wikidata.org/wiki/Q133036","display_name":"Lithography","level":2,"score":0.43417638540267944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38421040773391724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24438077211380005},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.16444095969200134},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.14074298739433289},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.12306609749794006},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.11124062538146973},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/ijcnn.2005.1556425","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ijcnn.2005.1556425","pdf_url":null,"source":{"id":"https://openalex.org/S4363609022","display_name":"Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005.","raw_type":"proceedings-article"},{"id":"pmh:oai:cisti-icist.nrc-cnrc.ca:cistinparc:12346365","is_oa":false,"landing_page_url":"https://nrc-publications.canada.ca/fra/voir/objet/?id=27fd88ea-3815-4731-a1e2-8e677f01d73e","pdf_url":null,"source":{"id":"https://openalex.org/S7407055245","display_name":"NPARC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W249811272","https://openalex.org/W2001099397","https://openalex.org/W2012354516","https://openalex.org/W2037093113","https://openalex.org/W2041723792","https://openalex.org/W2047608799","https://openalex.org/W2053552455","https://openalex.org/W2072127486","https://openalex.org/W2084932240","https://openalex.org/W2086418243","https://openalex.org/W2110014101","https://openalex.org/W2131082021","https://openalex.org/W2131716718","https://openalex.org/W2162318647","https://openalex.org/W2166261688"],"related_works":["https://openalex.org/W1979808816","https://openalex.org/W2378045033","https://openalex.org/W2136647108","https://openalex.org/W2465699412","https://openalex.org/W2381864073","https://openalex.org/W2092867183","https://openalex.org/W4286285965","https://openalex.org/W1565353949","https://openalex.org/W1965180958","https://openalex.org/W2350029007"],"abstract_inverted_index":{"Hybrid":[0],"silicon-polymer":[1],"chips":[2,51],"with":[3,85],"microscale":[4],"topography":[5],"and":[6,20,33,55,61,65,100,125,137,141],"contrasting":[7],"surface":[8],"chemistries":[9],"were":[10],"created":[11],"using":[12],"a":[13,26,79,89,104,116],"novel":[14,80],"combination":[15],"of":[16,70,88,103,134],"soft":[17],"lithography":[18],"techniques,":[19],"evaluated":[21],"for":[22],"their":[23],"suitability":[24],"as":[25,115],"platform":[27,76,112],"to":[28,40,77,118,131],"guide":[29],"cell":[30,98],"attachment,":[31],"growth":[32,54],"differentiation.":[34],"These":[35],"capabilities":[36],"are":[37],"all":[38],"necessary":[39],"synthesize":[41],"organized":[42],"neural":[43],"networks":[44],"in":[45],"vitro.":[46],"Neurons":[47],"developed":[48],"on":[49],"these":[50],"exhibit":[52],"patterned":[53],"functional":[56],"communication,":[57],"evidenced":[58],"by":[59],"spontaneous":[60],"stimulated":[62],"action":[63],"potentials":[64],"intracellular":[66],"calcium":[67],"oscillations.":[68],"Integration":[69],"planar":[71],"patch-clamp":[72],"technology":[73],"into":[74,108],"this":[75],"create":[78],"long-term":[81],"interface":[82],"is":[83],"presented,":[84],"the":[86,96,101,109,132,148],"formation":[87],"high":[90,142],"resistance":[91],"(giga-ohm)":[92],"electrical":[93],"seal":[94],"between":[95],"cultured":[97],"membrane":[99],"perimeter":[102],"micron-sized":[105],"orifice":[106],"integrated":[107],"substrate.":[110],"This":[111],"has":[113],"potential":[114],"tool":[117],"investigate":[119],"mechanisms":[120],"underlying":[121],"neuro-genesis,":[122],"synaptic":[123],"transmission,":[124],"neuro-degeneration.":[126],"It":[127],"may":[128],"also":[129],"lead":[130],"development":[133],"more":[135],"sophisticated":[136],"functionally":[138],"relevant":[139],"bioassays":[140],"throughput":[143],"electrophysiological":[144],"screening,":[145],"thus":[146],"speeding":[147],"drug":[149],"discovery":[150],"process.":[151]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-03-02T08:37:19.008085","created_date":"2025-10-10T00:00:00"}
